Mutations affecting RNA Polymerase associated with Rifampicin Resistance in Escherichia coli

Nature ◽  
1968 ◽  
Vol 220 (5164) ◽  
pp. 276-277 ◽  
Author(s):  
DAVID H. EZEKIEL ◽  
JOAN E. HUTCHINS
Keyword(s):  
Escherichia Coli ◽  
Rna Polymerase ◽  
Rifampicin Resistance

Identification of Rifampicin Resistance Mutations in Escherichia coli, Including an Unusual Deletion Mutation

2017 ◽  
Vol 27 (6) ◽  
pp. 356-362 ◽  
Author(s):  
Eugene Y. Wu ◽  
Angela K. Hilliker
Keyword(s):  
Escherichia Coli ◽  
Rna Polymerase ◽  
Bacterial Infections ◽  
Deletion Mutant ◽  
Deletion Mutation ◽  
Rifampicin Resistance ◽  
Clinical Settings ◽  
Resistance Mutations ◽  
Gene Encoding ◽  
Β Chain

Rifampicin is an effective antibiotic against mycobacterial and other bacterial infections, but resistance readily emerges in laboratory and clinical settings. We screened <i>Escherichia coli</i> for rifampicin resistance and identified numerous mutations to the gene encoding the β-chain of RNA polymerase (<i>rpoB</i>), including an unusual 9-nucleotide deletion mutation. Structural modeling of the deletion mutant indicates locations of potential steric clashes with rifampicin. Sequence conservation in the region near the deletion mutation suggests a similar mutation may also confer resistance during the treatment of tuberculosis.

RNA polymerase rifampicin resistance mutations in Escherichia coli: Sequence changes and dominance

1983 ◽  
Vol 190 (2) ◽  
pp. 344-348 ◽  
Author(s):  
Yuri A. Ovchinnikov ◽  
Galina S. Monastyrskaya ◽  
Sergei O. Guriev ◽  
Nadezhda F. Kalinina ◽  
Eugene D. Sverdlov ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Rna Polymerase ◽  
Rifampicin Resistance ◽  
Resistance Mutations

Mutation to rifampicin resistance at the beginning of the RNA polymerase β subunit gene in Escherichia coli

1984 ◽  
Vol 196 (1) ◽  
pp. 173-174 ◽  
Author(s):  
N. A. Lisitsyn ◽  
E. D. Sverdlov ◽  
E. P. Moiseyeva ◽  
O. N. Danilevskaya ◽  
V. G. Nikiforov
Keyword(s):  
Escherichia Coli ◽  
Rna Polymerase ◽  
Rifampicin Resistance ◽  
Β Subunit ◽  
Subunit Gene

scholarly journals Stringent control in Escherichia coli applies also to transcription by T7 RNA polymerase.

1987 ◽  
Vol 262 (9) ◽  
pp. 3940-3943
Author(s):  
M. Yamagishi ◽  
J.R. Cole ◽  
M. Nomura ◽  
F.W. Studier ◽  
J.J. Dunn
Keyword(s):  
Escherichia Coli ◽  
Rna Polymerase ◽  
T7 Rna Polymerase ◽  
Stringent Control
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