Effect of Adrenergic Blocking Agents on the Calcium Pump of the Fragmented Cardiac Sarcoplasmic Reticulum

Nature ◽  
1968 ◽  
Vol 220 (5162) ◽  
pp. 79-80 ◽  
Author(s):  
MICHAEL L. HESS ◽  
F. NORMAN BRIGGS ◽  
ELLIOT SHINEBOURNE ◽  
JOHN HAMER
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Calcium Pump ◽  
Cardiac Sarcoplasmic Reticulum ◽  
Blocking Agents ◽  
Adrenergic Blocking ◽  
Adrenergic Blocking Agents

Stimulation of calcium pump activity in heart sarcolemma by timolol

1983 ◽  
Vol 61 (3) ◽  
pp. 240-244 ◽  
Author(s):  
Andre Dzurba ◽  
Pallab K. Ganguly ◽  
Robert E. Beamish ◽  
Naranjan S. Dhalla
Keyword(s):  
Membrane Fluidity ◽  
Concanavalin A ◽  
Rat Heart ◽  
Calcium Pump ◽  
Blocking Agents ◽  
Heart Sarcolemma ◽  
Pump Activity ◽  
Adrenergic Blocking ◽  
Stimulation Of ◽  
Adrenergic Blocking Agents

The effects of β-adrenergic blocking agents, timolol and atenolol (1–1000 μM), were studied on rat heart sarcolemmal ATPase and Ca2+ binding activities. Timolol, unlike atenolol, increased both Ca2+-stimulated ATPase and ATP-dependent Ca2+ binding; the maximal effects were seen at 1 μM concentration of timolol. Both timolol and atenolol did not alter the sarcolemmal Mg2+ ATPase and nonspecific Ca2+ binding activities. Sarcolemmal Ca2+ -stimulated ATPase was also activated by concanavalin A (6–66 μg/mL) which is known to alter membrane fluidity; however, Mg2+ ATPase was unaffected by this agent. These results indicate that timolol may stimulate Ca2+ pump activity in heart sarcolemma by changing membrane fluidity in a manner similar to that of concanavalin A.

Cardioselective .beta.-adrenergic blocking agents. 1. 1-[(3,4-Dimethoxyphenethyl)amino]-3-aryloxy-2-propanols

1975 ◽  
Vol 18 (2) ◽  
pp. 148-152 ◽  
Author(s):  
Milton L. Hoefle ◽  
Stephen G. Hastings ◽  
Robert F. Meyer ◽  
Ruth M. Corey ◽  
Ann Holmes ◽  
...  
Keyword(s):  
Beta Adrenergic ◽  
Blocking Agents ◽  
Adrenergic Blocking ◽  
Beta Adrenergic Blocking Agents ◽  
Adrenergic Blocking Agents
Sign in / Sign up

Export Citation Format

Share Document