Isolation of a Sex Hormone from the Water Mould Achlya bisexualis

Abstract. Sex hormone binding globulin (SHBG) levels were studied for possible effects of oestradiol-17β on SHBG. No change in SHBG plasma was recorded during normal menstrual cycles or during treatment with oestradiol-17β to menopausal women. However, gonadotrophin treatment to amenorrhoeic women to induce ovulation resulted in high oestradiol concentrations and a pronounced increase in SHBG was found during the luteal phase of these cycles. A marked increase of SHBG was also recorded in a woman with pronounced fluctuations of oestradiol during treatment with levonorgestrel sc implants for contraception. In conclusion, effects on SHBG were only found when extraordinarily high levels of plasma oestradiol were recorded.

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A new biological androgen sensitivity test: the sex hormone binding globulin (SHBG)-response to the anabolic steroid stanozolol

Acta Endocrinologica ◽

10.1530/acta.0.117s215 ◽

1988 ◽

Vol 117 (4_Suppl) ◽

pp. S215-S216 ◽

Cited By ~ 1

Author(s):

G. SINNECKER ◽

S. KÖHLER

Keyword(s):

Anabolic Steroid ◽

Sex Hormone ◽

Sensitivity Test ◽

Sex Hormone Binding Globulin ◽

Hormone Binding ◽

Androgen Sensitivity

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Sex hormone-binding globulin (SHBG) and androgen levels in women with androgenetic alopecia

Acta Endocrinologica ◽

10.1530/acta.0.114s144 ◽

1987 ◽

Vol 116 (3_Suppl) ◽

pp. S144 ◽

Cited By ~ 1

Author(s):

G. SINNECKER ◽

E. LUDWIG ◽

A. KRENZ ◽

R.P. WILLIG

Keyword(s):

Sex Hormone ◽

Sex Hormone Binding Globulin ◽

Androgenetic Alopecia ◽

Hormone Binding ◽

Androgen Levels

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ÜBER DIE BILDUNG VON ENDOMETRIALEN KÖRNCHENZELLEN BEI KASTRATINNEN UNTER HORMONEINFLUSS

Acta Endocrinologica ◽

10.1530/acta.0.xxxiii0261 ◽

1960 ◽

Vol XXXIII (II) ◽

pp. 261-276 ◽

Cited By ~ 9

Author(s):

G. Hellweg ◽

J. Ferin ◽

K. G. Ober

Keyword(s):

Hormone Therapy ◽

Stromal Cells ◽

Sex Hormone ◽

Substitution Therapy ◽

Secretory Phase ◽

Hormone Substitution ◽

Endometrial Stromal Cells ◽

Endometrial Stroma ◽

K Cells

ABSTRACT 65 endometrial biopsies from castrated women who had received either natural or artificial sex hormone therapy were studied microscopically. Attention was paid to various histologic criteria, especially to the number of endometrial granulocytes (»K« cells, KZ). The following was obtained: The »K« cells are completely absent when no hormone substitution therapy is given. They were also lacking when the castrated patients were treated only with oestrogens, even if the dose given was ten-times that found in women during the reproductive ages. In contrast, the »K« cells developed from the endometrial stromal cells only under influence of progesterone, usually appearing first 8–10 days after the administration of the gestagen. The »K« cells were demonstrable in the number corresponding to a normal secretory phase only then, when the oestrogen-progesterone dosage ratio had induced a fully-developed secretory change, as measured by the usual histologic criteria. With an overdosage of oestrogen the »K« cells were either absent or were very sparse. Contrarily, an overdosage of progesterone had no influence on their number. The development of endometrial glands does not always entirely parallel that of the stroma in castrated patients following hormone therapy. A more exact indicator for the proper dose for the production of a secretory phase by hormone therapy seems to be the number of »K« cells in the endometrial stroma.

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