Unusual Human Agglutinin defining a Serological Difference between Australian Trout Species

Nature ◽  
1967 ◽  
Vol 214 (5095) ◽  
pp. 1361-1362 ◽  
Author(s):  
M. L. VERSO
Keyword(s):  
Serological Difference

scholarly journals A Serological Study of Undulant Fever in Southern Rhodesia

1927 ◽  
Vol 26 (4) ◽  
pp. 403-419 ◽  
Author(s):  
G. R. Ross
Keyword(s):  
Absorption Test ◽  
Serological Study ◽  
Serological Investigation ◽  
Southern Rhodesia ◽  
Serological Difference ◽  
The One ◽  
Type Strains

1. Examination of nine type strains of Brucella, collected from various sources, by agglutination and the absorption of agglutinin test revealed distinct serological difference between Br. abortus and Br. melitensis. Differentiation could only be made by the agglutinin-absorption test, both organisms agglutinating equally with abortus or melitensis immune sera.2. By agglutination alone differentiation could be made between a group consisting of Br. melitensis and Br. abortus strains on the one hand and a group which included one strain labelled Br. melitensis, one labelled Br. abortus, and Br. paramelitensis.3. The agglutinin-absorption test showed that this Br. paramelitensis group comprised two strains of closely allied paramelitensis strains, and that the Br. abortus strain could be regarded as a Br. para-abortus strain.4. Serological investigation of eight strains of Brucella isolated from patients suffering from undulant fever in Southern Rhodesia showed that six were serologically identical with type Br. abortus and two identical with what is regarded as a Br. para-abortus strain.5. It is suggested that the melitensis-abortus group represent the “S” normal types, whereas the paramelitensis-para-abortus group represent the “R” mutant types of organisms.

scholarly journals THE IMMUNOLOGICAL SPECIFICITY OF CHEMICALLY ALTERED PROTEINS

1930 ◽  
Vol 51 (2) ◽  
pp. 295-317 ◽  
Author(s):  
Arthur Wormall
Keyword(s):  
Structural Similarity ◽  
Species Specificity ◽  
Aromatic Nucleus ◽  
Hydroxyl Group ◽  
Ortho Position ◽  
Homologous Antigen ◽  
The Difference ◽  
Serological Difference ◽  
Original Species ◽  
Altered Proteins

The serological properties of iodoproteins prepared by a method which involves less drastic treatment of the protein than the methods previously used for this purpose confirm the findings of Obermayer and Pick (1) and later authors, that iodination of proteins results in a more or less complete loss of species specificity and that a new specificity characteristic for iodoproteins is produced. A serological investigation of brominated proteins has been made for the first time. These preparations are only slightly different from iodized proteins in their serological properties. Evidence is submitted which indicates that the radical in iodoproteins which is responsible for the specificity is not iodine but the 3:5 dihalogenated tyrosine grouping. Thus marked inhibition of the iodoprotein (or bromoprotein) precipitin reactions is effected by 3:5 dihalogenated tyrosine, not by iodophenol or potassium iodide. A reinvestigation has been made of the serological properties of nitrated and diazotized proteins. Proteins nitrated by nitric acid, or by a method which does not appear to have been used for proteins hitherto, namely nitration with tetranitromethane in neutral or slightly alkaline solution, acquire a new common serological specificity. The nitrated proteins and diazotized proteins show, in confirmation of the results of Landsteiner and Prášek (22) and in contrast to the findings of Obermayer and Pick, very little difference in their reactions. Thus diazotized proteins and proteins nitrated by either of the two methods above mentioned react equally well with any nitroprotein antiserum. This interaction exists in spite of the difference in the substituents, either because the substitution with the nitro- or diazo-group occurs in the same position in the aromatic nucleus, possibly in the ortho position to the hydroxyl group, or because of some other structural similarity. In the last connection it is suggested that both compounds may have a quinoid structure as has been assumed for ortho-nitrophenols. Whilst this assumption could account for the marked serological difference of nitrated and halogenated proteins it should also be mentioned that iodination (and bromination) lead to a disubstitution of halogen in the two ortho positions relative to the hydroxyl group of the tyrosine whereas nitration of proteins probably results in the formation of mononitrotyrosine and substitution in the tryptophane group as well (19, 36, 20-a). It is probably impossible therefore, to draw a strict analogy between nitration (or diazotization) and halogenation of proteins since a comparison of their immunological properties is not exactly a comparison of the effect of substituting a different group in the same position. Accordingly it would appear that as yet no definite conclusions can be drawn as to the serological effect of differences in the chemical nature of various substituents in the aromatic nucleus although some influence is likely for general reasons. All of the chemically altered proteins still retain a small amount of the original species specificity, and the antisera always react to a slightly greater extent with the homologous antigen than with similarly treated antigens prepared from heterologous sera. This difference occurs even when the possibility of some unaltered protein being present in the antigen can be practically excluded.

scholarly journals SEROLOGICAL DISTINCTION OF MUTANTS B6.C-H(z1) AND B6.M505 FROM STRAIN C57BL/6

1974 ◽  
Vol 140 (4) ◽  
pp. 1127-1132 ◽  
Author(s):  
Jan Klein ◽  
Miroslav Hauptfeld ◽  
Věra Hauptfeld
Keyword(s):  
Current Concept ◽  
Original Strain ◽  
Immune Reactions ◽  
Serological Difference

A quantitative serological difference was found between strains Hz1 and M505 carrying mutant H-2 haplotypes ba and bd, respectively, and the original strain B6(H-2b). The finding suggests that the mutations occurred in the H-2Kb gene, and together with data on MLR and CML challenges the current concept of H-2 regions' involvement in immune reactions.

Is there a serological difference between men and women with primary biliary cirrhosis?

1999 ◽  
Vol 94 (9) ◽  
pp. 2482-2486 ◽  
Author(s):  
Greg Nalbandian ◽  
Judy Water ◽  
Robert Gish ◽  
Michael Manns ◽  
Ross L. Coppel ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis ◽  
Men And Women ◽  
Serological Difference

scholarly journals A SEROLOGICAL CLASSIFICATION OF VIRIDANS STREPTOCOCCI WITH SPECIAL REFERENCE TO THOSE ISOLATED FROM SUBACUTE BACTERIAL ENDOCARDITIS

1942 ◽  
Vol 76 (1) ◽  
pp. 109-126 ◽  
Author(s):  
Mathilde Solowey
Keyword(s):  
Special Reference ◽  
Bacterial Endocarditis ◽  
Streptococcus Salivarius ◽  
Viridans Streptococci ◽  
Subacute Bacterial Endocarditis ◽  
Serological Classification ◽  
Serological Difference

A total of 108 strains of viridans streptococci from subacute bacterial endocarditis, and 99 strains from human throats and extracted teeth have been studied, and approximately two-thirds of all the strains so far have been differentiated into a number of serological groups. The similarity between strains from these sources is evident from the fact that approximately 50 per cent of the reacting strains from each source fall into two groups I and II, and that three groups I, II, and IV, contain streptococci from both sources in approximately the same distribution. Fifteen vaginal strains of viridians streptococci failed, with the exception of one strain, to react with groups I–IV of the endocarditis serums. More than three-fourths of the strains from both sources were Streptococcus salivarius as determined by Sherman's criteria. However, no correlation between the biochemical and serological classification could be made. It may be concluded that the viridans streptococci are amenable to classification by serological methods. The results so far obtained do not indicate a serological difference between strains of viridans streptococci isolated from subacute bacterial endocarditis, and those isolated from human throats and extracted teeth. The greater definitive value of serological methods in the identification of a particular strain is indicated.

Production of Monoclonal Antibody Discriminating Serological Difference inEscherichia coliO9 and O9a Polysaccharides

1997 ◽  
Vol 41 (7) ◽  
pp. 519-525 ◽  
Author(s):  
Nobuo Kido ◽  
Naoki Morooka ◽  
Noriko Paeng ◽  
Taizo Ohtani ◽  
Hidemitsu Kobayashi ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Serological Difference

SEROLOGICAL DIFFERENCE BETWEEN OLD AND YOUNG CELLS

The Lancet ◽  
1960 ◽  
Vol 276 (7143) ◽  
pp. 211
Author(s):  
C. Hougie
Keyword(s):  
Serological Difference
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