Effect of Adrenaline and Adrenergic Blocking Agents on the Basal Oxygen Consumption of the Perfused Rat Heart

Nature ◽  
1966 ◽  
Vol 210 (5040) ◽  
pp. 999-1000
Author(s):  
DAVID R. CHALLONER
Keyword(s):  
Oxygen Consumption ◽  
Rat Heart ◽  
Perfused Rat Heart ◽  
Blocking Agents ◽  
Adrenergic Blocking ◽  
Adrenergic Blocking Agents

scholarly journals Comparative studies on effects of β-adrenergic blocking agents, quinidine and lidocaine on rat heart muscles

1975 ◽  
Vol 25 ◽  
pp. 67-68
Author(s):  
Mitsuhiro Nagata ◽  
Jun’o Shimamoto ◽  
Hiroko Murakami ◽  
Jiro Sugimoto ◽  
Masao Morita
Keyword(s):  
Comparative Studies ◽  
Rat Heart ◽  
Blocking Agents ◽  
Adrenergic Blocking ◽  
Adrenergic Blocking Agents

Stimulation of calcium pump activity in heart sarcolemma by timolol

1983 ◽  
Vol 61 (3) ◽  
pp. 240-244 ◽  
Author(s):  
Andre Dzurba ◽  
Pallab K. Ganguly ◽  
Robert E. Beamish ◽  
Naranjan S. Dhalla
Keyword(s):  
Membrane Fluidity ◽  
Concanavalin A ◽  
Rat Heart ◽  
Calcium Pump ◽  
Blocking Agents ◽  
Heart Sarcolemma ◽  
Pump Activity ◽  
Adrenergic Blocking ◽  
Stimulation Of ◽  
Adrenergic Blocking Agents

The effects of β-adrenergic blocking agents, timolol and atenolol (1–1000 μM), were studied on rat heart sarcolemmal ATPase and Ca2+ binding activities. Timolol, unlike atenolol, increased both Ca2+-stimulated ATPase and ATP-dependent Ca2+ binding; the maximal effects were seen at 1 μM concentration of timolol. Both timolol and atenolol did not alter the sarcolemmal Mg2+ ATPase and nonspecific Ca2+ binding activities. Sarcolemmal Ca2+ -stimulated ATPase was also activated by concanavalin A (6–66 μg/mL) which is known to alter membrane fluidity; however, Mg2+ ATPase was unaffected by this agent. These results indicate that timolol may stimulate Ca2+ pump activity in heart sarcolemma by changing membrane fluidity in a manner similar to that of concanavalin A.

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