Multi-motor End-plate Muscle Fibres in the Human Vocalis Muscle

Nature ◽  
1965 ◽  
Vol 206 (4984) ◽  
pp. 629-630 ◽  
Author(s):  
G. ROSSI ◽  
G. CORTESINA
Keyword(s):  
Muscle Fibres ◽  
End Plate ◽  
Motor End Plate

scholarly journals Fatigue and plurisegmental innervation of individual muscle fibres

1925 ◽  
Vol 98 (692) ◽  
pp. 493-505 ◽  
Keyword(s):  
Nerve Stimulation ◽  
Optical Method ◽  
Complex Problem ◽  
Muscular Fatigue ◽  
Alternative View ◽  
Muscle Fibres ◽  
Individual Muscle ◽  
End Plate ◽  
Motor End Plate

The classical experiments of Waller (1893) and others in which a muscle, fatigued to inexcitability by nerve stimulation, was shown still to respond to stimuli applied directly, led to the conclusion that fatigue occurred at the motor end-plate. Some have inferred from this and similar experiments that the hypothetical junctional tissue, when fatigued, conducts with a decrement (Lucas, 1917). These inferences have recently been supported by the experiments of Cattell and Stiles (1924), and independently by those of Beritoff (1924, a and b ). Though the usefulness of the theory of neuro-muscular fatigue commonly held has been very great, it seems, nevertheless, possible to place another interpretation upon Waller’s, Lucas’s, Cattell and Stiles’s, and Beritoff’s experiments, and, as an alternative view is sometimes helpful in the solution of a complex problem, it is hoped that the following view may prove suggestive and of some value. A description will first be given of a repetition of Cattell and Stiles’s and of Beritoff’s experiments, using the optical method previously described (1925, a ).

The electric activity of the motor end-plate

1952 ◽  
Vol 140 (899) ◽  
pp. 183-186 ◽  
Keyword(s):  
Muscle Fibre ◽  
Motor Nerve ◽  
Nerve Impulse ◽  
Electric Activity ◽  
Muscle Fibres ◽  
Specific Chemical ◽  
End Plate ◽  
Motor End Plate ◽  
Direct Spread ◽  
Nerve Muscle

At the nerve-muscle junction, a specific process occurs which is not found during the propagation of impulses along nerve or muscle fibres; the nerve impulse causes acetylcholine (Ach) to be released from the motor nerve endings, and this substance depolarizes the end-plate surface of the muscle fibre by a specific chemical reaction. The transient local depolarization of the muscle fibre which is so produced has been called the end-plate potential (e.p.p.). The e.p.p., then, unlike the nerve or muscle impulse, is not itself produced by electric stimulation (direct spread of electric current from nerve to muscle has, in fact, never been demonstrated and appears to be indetectably small). On the other hand, the e.p.p. electrically stimulates the surrounding region of the muscle fibre, and so gives rise to the propagation of a new impulse.

Experimental neonatal autoimmune myasthenia gravis: an immunohistochemical, ultrastructural and electrophysiological study of the motor end-plate

1995 ◽  
Vol 132 (2) ◽  
pp. 97-104
Author(s):  
Naoko Tetsuo ◽  
Mitsuhiro Tsujihata ◽  
Akira Satoh ◽  
Toshiro Yoshimura ◽  
Tatsufumi Nakamura ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Electrophysiological Study ◽  
End Plate ◽  
Motor End Plate ◽  
Autoimmune Myasthenia

A study of the effect of X-rays on the electrical properties of mammalian nerve and muscle

1963 ◽  
Vol 157 (969) ◽  
pp. 536-561 ◽  
Keyword(s):  
Dose Rate ◽  
Action Potentials ◽  
Time Course ◽  
Low Dose ◽  
High Dose ◽  
X Rays ◽  
Low Dose Rate ◽  
End Plate ◽  
Small Doses ◽  
Motor End Plate

Resting potentials, action potentials, and miniature end-plate potentials have been re­corded from isolated phrenic-diaphragm preparations of the rat during and after irradiation with X-rays. Relatively small doses of a few thousand roentgens have no obvious effect on the preparation for many hours but larger doses, of the order of 70 to 150 kr irreversibly block neuromuscular transmission. The block is not accompanied by any change in the size of action potentials, resting potentials, membrane constants or miniature potentials recorded in the muscle with intracellular electrodes, or in the size of action potentials recorded in the nerve. Records made at the motor end-plate show that the cause of the block is a ‘pre-synaptic ’ failure of impulse propagation in the intramuscular part of the nerve. The time course of the failure depends largely on the rate at which X-rays are delivered to the pre­paration: at a high dose-rate (70kr/min) the block develops rapidly and is accompanied by an increase in the frequency of miniature potentials; at a low dose-rate (7 kr/min) larger doses are required, the latency is longer and the miniature potentials continue at a normal frequency. The sequence in which different parts of the muscle become blocked, the abrupt nature of the failure at an individual motor end-plate, and the increase in frequency of the miniature potentials together suggest that the action of X-rays is to block conduction in the nerve near its terminals, possibly by depolarizing points where the axons branch and the safety factor for the propagation of impulses is low. The results reported in this paper do not support the hypotheses that small doses of X-rays at a high or a low dose-rate lead to an initial 'enhancement' of function or that they produce immediate and reversible changes in the permeability of excitable membranes to ions.

Dysfunction at the motor end-plate and axon membrane in Guillain-Barré syndrome: A single-fiber EMG study

2003 ◽  
Vol 27 (4) ◽  
pp. 426-434 ◽  
Author(s):  
Frank Spaans ◽  
Jan-Willem Vredeveld ◽  
Humphrey H.E. Morré ◽  
Bart C. Jacobs ◽  
Marc H. De Baets
Keyword(s):  
Single Fiber ◽  
Guillain Barre Syndrome ◽  
Axon Membrane ◽  
End Plate ◽  
Guillain Barré Syndrome ◽  
Motor End Plate ◽  
Guillain Barré

Effects of long-term administration of ambenonium chloride on motor end-plate fine structure and acetylcholine receptor in rat

1981 ◽  
Vol 51 (1) ◽  
pp. 69-79 ◽  
Author(s):  
Ryuji Hazama ◽  
Mitsuhiro Tsujihata ◽  
Masataka Mori ◽  
Masaharu Takamori ◽  
Kazutake Mori ◽  
...  
Keyword(s):  
Fine Structure ◽  
Acetylcholine Receptor ◽  
End Plate ◽  
Motor End Plate ◽  
Term Administration

The Dogfish Neuromuscular Junction: Dual Innervation of Vertebrate Striated Muscle Fibres?

1972 ◽  
Vol 10 (3) ◽  
pp. 657-665
Author(s):  
Q. BONE
Keyword(s):  
Neuromuscular Junction ◽  
Nerve Terminal ◽  
Striated Muscle ◽  
Dense Core ◽  
The Other ◽  
Muscle Fibres ◽  
Nerve Terminals ◽  
Nerve Fibres ◽  
Different Types ◽  
Motor End Plate

In the myotomal muscles of the dogfish, Scyliorhinu canicula, there are 2 major types of fibre. The red fibres at the periphery of the myotome receive a distributed en grappe pattern of innervation. There are subjunctional folds at these endings, and the nerve terminals contain vesicles around 50 nm in diameter. In contrast to this, the white twitch fibres of the myotome are innervated focally, by 2 nerve fibres passing to the same motor end-plate. These 2 fibres contain vesicles of different types. One type of nerve terminal contains vesicles around 50 nm in diameter; these terminals resemble those upon the red fibres. The other contains vesicles up to 100 nm in diameter, frequently possessing a dense core. It is suggested that the white twitch fibres of dogfish are innervated by 2 separate axons, possibly containing different transmitter substances.

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