Renin-angiotensin System in the Spontaneously Hypertensive Rat

Nature ◽  
1965 ◽  
Vol 205 (4966) ◽  
pp. 90-90 ◽  
Author(s):  
H. SOKABE
Keyword(s):  
Spontaneously Hypertensive Rat ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Spontaneously Hypertensive ◽  
Renin Angiotensin ◽  
Hypertensive Rat

Mechanism of Suppressed Renin-Angiotensin System in Spontaneously Hypertensive Rat (Shr)

1983 ◽  
Vol 5 (1) ◽  
pp. 49-70 ◽  
Author(s):  
Mikio Watanabe ◽  
Tetsuo Nishikawa ◽  
Taira Takagi ◽  
Yoshihisa Kamiyama ◽  
Yasushi Tamura ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rat ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Spontaneously Hypertensive ◽  
Renin Angiotensin ◽  
Hypertensive Rat

Significance of the Brain Renin—Angiotensin System in Spontaneously Hypertensive Rats

1982 ◽  
Vol 63 (s8) ◽  
pp. 159s-161s ◽  
Author(s):  
Jeroen A. D. M. Tonnaer ◽  
Joke J. van Put ◽  
Victor M. Wiegant ◽  
Wybren de Jong
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Spontaneously Hypertensive Rat ◽  
Renin Angiotensin System ◽  
Hypotensive Effect ◽  
Sympathetic Outflow ◽  
Hypertensive Rats ◽  
Angiotensin System ◽  
Spontaneously Hypertensive ◽  
Renin Angiotensin ◽  
The Brain

1. The renin inhibitor N-acetyl-pepstatin was infused for 14 days or 5 days into the cerebral ventricular system of young and adult spontaneously hypertensive rats respectively. 2. The blood pressure and heart rate of the young animals was significantly lower as a result of this treatment, whereas the pressure of the adult animals tended to decrease. 3. The mechanism involved in the hypotensive effect of N-acetyl-pepstatin appeared to be independent of the peripheral renin-angiotensin system. The possible involvement of a decreased sympathetic outflow is suggested. 4. The present data indicate that the brain renin-angiotensin system contributes to the development of hypertension in the spontaneously hypertensive rat.

Sign in / Sign up

Export Citation Format

Share Document