Effects of Single and Fractionated Doses of Total Body X-Irradiation in Utero on Growth of the Brain and its Parts

Nature ◽  
1964 ◽  
Vol 202 (4929) ◽  
pp. 262-264 ◽  
Author(s):  
K. R. BRIZZEE
Keyword(s):  
In Utero ◽  
X Irradiation ◽  
Total Body ◽  
The Brain

THE EFFECTS OF X-IRRADIATION ON PROTEIN METABOLISM OF THE BRAIN

1965 ◽  
Vol 43 (7) ◽  
pp. 1091-1098 ◽  
Author(s):  
Shozo Nakazawa ◽  
Takao Hara ◽  
Komei Ueki
Keyword(s):  
Rat Brain ◽  
Protein Metabolism ◽  
Leucine Incorporation ◽  
Adult Rats ◽  
Rat Brain And Liver ◽  
Glucose Incorporation ◽  
X Irradiation ◽  
Total Body ◽  
The Brain

The effects of X-irradiation on the metabolism of rat brain, liver, and spleen have been studied. C14-Glucose incorporation into protein of the brain of newborn rats was affected significantly by total body X-irradiation (250 r each day for 4 days). C14-Leucine incorporation into protein of the brain, liver, and spleen of adult rats was also reduced by total body X-irradiation (300 r each day for 4 days).X-irradiation of the head (500 r each day for 6 days) affected C14-leucine incorporation into protein of rat brain and liver, but it did not affect that of spleen.X-irradiation in vitro (5000 r) did not have any effect on protein metabolism of rat brain. The mode of action of X-irradiation on protein metabolism is discussed.

Effect of Total Body X-Irradiation on the Respiration of the Homogenized Duodenal Mucosa of the Rat

Nature ◽  
1957 ◽  
Vol 179 (4549) ◽  
pp. 51-51 ◽  
Author(s):  
S. SZŐNYI ◽  
W. VÁRTERÉSZ
Keyword(s):  
Duodenal Mucosa ◽  
X Irradiation ◽  
Total Body

Effect of total body x-irradiation on some enzymes of rat tissues

1953 ◽  
Vol 44 (1) ◽  
pp. 95-101 ◽  
Author(s):  
Jay S. Roth ◽  
Herbert J. Eichel ◽  
Arthur Wase ◽  
Carl Alper ◽  
M.John Boyd
Keyword(s):  
Rat Tissues ◽  
X Irradiation ◽  
Total Body

Tumor Induction in Rats by Single Total-Body X-Irradiation

1957 ◽  
Vol 6 (3) ◽  
pp. 339 ◽  
Author(s):  
R. T. Binhammer ◽  
J. C. Finerty ◽  
M. Schneider ◽  
A. W. B. Cunningham
Keyword(s):  
Tumor Induction ◽  
X Irradiation ◽  
Total Body

Late Effects of Total-Body X-Irradiation: VI. Increased Susceptibility of Irradiated Rats to Oral Hypertonic Sodium Chloride

1962 ◽  
Vol 16 (1) ◽  
pp. 54 ◽  
Author(s):  
Baldwin G. Lamson ◽  
Daniel A. Lang ◽  
Marta S. Billings ◽  
J. J. Gambino ◽  
Leslie R. Bennett
Keyword(s):  
Sodium Chloride ◽  
Late Effects ◽  
X Irradiation ◽  
Total Body ◽  
Increased Susceptibility

Narcotic Poisoning of Children (1) Through Accidental Ingestion of Methadone and (2) in utero

PEDIATRICS ◽  
1974 ◽  
Vol 54 (3) ◽  
pp. 329-332
Author(s):  
Saul Blatman
Keyword(s):  
Gastrointestinal Tract ◽  
Clinical Medicine ◽  
Well Being ◽  
Pharmacological Action ◽  
In Utero ◽  
Abuse Liability ◽  
Practice Of Medicine ◽  
Life Threatening ◽  
Repeated Use ◽  
The Brain

Narcotics have been known to man since prehistoric times, and they continue to be among the most used analgesics in the practice of medicine. They comprise a group of drugs whose analgesic effect is coupled with euphoria and somnolence. In addition, their spasmogenic effect on smooth muscle has made them useful agents in the alleviation of certain gastrointestinal tract symptoms. For most narcotics, therapeutic dosage does not produce serious untoward effects. Unfortunately, they have a depressant effect on respiration by directly influencing the respiratory center of the brain. This may be life threatening when recommended dosages are exceeded. Narcotics have been abused since the recognition that they can induce euphoria and a feeling of well being. Tolerance and physical and psychological dependence result from their repeated use. The occurrence of withdrawal symptomatology in humans using these drugs repeatedly helps to produce a pattern of drug dependence; an individual has but to repeat a dose of drug in order to prevent withdrawal symptoms. Abuse liability is thus great. All narcotics share this addiction potential. Those most frequently prescribed in clinical medicine are morphine, trieperidine, codeine and methadone. Heroin (diacetylmorphine), the most commonly abused narcotic, available only illicitly, is not prescribed in clinical practice. After injection, it is hydrolyzed to morphine which produces its pharmacological action. While morphine and heroin are absorbed only following parenteral administration, some narcotics are absorbed readily from the gastrointestinal tract as well as after injection (methadone, codeine, meperidine). Regardless of the mode of administration, narcotics taken by a pregnant addict readily pass the placental barrier and are capable of producing effects on the infant in utero and after birth.

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