scholarly journals Conversion of Tritiated-18-hydroxy-corticosterone to Aldosterone by Slices of Human Cortico-adrenal Gland and Adrenal Tumour

Nature ◽  
1964 ◽  
Vol 201 (4918) ◽  
pp. 501-501 ◽  
Author(s):  
JORGE R. PASQUALINI
Keyword(s):  
Adrenal Gland ◽  
Adrenal Tumour

ADRENAL ANGIOMYOLIPOMA: A SURGICAL RARITY

2021 ◽  
pp. 22-23
Author(s):  
Mikail Merchant ◽  
Sushrut Tendulkar ◽  
Abhijit Thakur ◽  
Seelam Lakshmi Mounika
Keyword(s):  
Back Pain ◽  
Early Diagnosis ◽  
Adrenal Gland ◽  
Laparoscopic Resection ◽  
Accurate Diagnosis ◽  
Uneventful Recovery ◽  
Minimal Risk ◽  
Adrenal Tumour ◽  
Systemic Symptoms ◽  
Hormonal Assay

Adrenal Angiomyolipoma's are extremely rare forms of lipomatous tumours of adrenal gland. They may go undetected for years without symptoms. The patient may become symptomatic, once the tumour has gained a signicant size, mainly back pain. We are reporting our case which is a one of a kind benign Adrenal tumour. Adrenal Angiomylipomas are found as incidentalomas in patients, generally presenting with mild to no symptoms, leading to a long delay before they are diagnosed. However, early diagnosis is key, not only to alleviate symptoms but to also prevent a future surgical disaster due to rupture causing cardiovascular shock if large enough. Our patient presented with dull aching ank pain without any systemic symptoms. The diagnosis requires a multifocal approach to be conrmed including hormonal assay and radiological testing whereas following a “clinical only” approach maybe insufcient and often mislead a clinician from establishing an accurate diagnosis. These patients could be offered laparoscopic resection at specialized centres with minimal risk of complication and early uneventful recovery.

Primitive neuroectodermal tumour (PNET) of the renal capsule mimicking solid adrenal tumour

2020 ◽  
Vol 13 (10) ◽  
pp. e235484
Author(s):  
Amrin Israrahmed ◽  
Somesh Singh ◽  
Hira Lal ◽  
Manoj Jain
Keyword(s):  
Adrenal Gland ◽  
Large Mass ◽  
Rare Entity ◽  
Renal Capsule ◽  
Review Of Literature ◽  
Adrenal Tumour ◽  
Primitive Neuroectodermal Tumour ◽  
Neuroectodermal Tumour ◽  
Suprarenal Mass ◽  
The Right

Primitive neuroectodermal tumour (PNET) of renal capsule is a rare entity. We report a case of a 17-year-old girl, who presented with symptoms of epigastric and right hypochondrium pain since 1 year. She was afebrile and physical examination revealed a soft, non-tender, firm, bimanually palpable and ballotable mass along right flank. Ultrasound abdomen showed a large heteroechoic mass in right suprarenal region with indistinct planes with upper pole of right kidney. On CT, a large right suprarenal mass was noted with origin likely from right adrenal gland. Surgery was done and intraoperatively, the large mass in right suprarenal region showed involvement of the upper pole of the right kidney. The right adrenal gland was small in size, compressed and displaced by the lesion. Histopathology revealed the mass to be PNET of kidney. We report the relevant imaging findings of the case with review of literature of this entity.

Cerebellin and cerebellin mRNA in the human brain, adrenal glands and the tumour tissues of adrenal tumour, ganglioneuroblastoma and neuroblastoma

1997 ◽  
Vol 154 (1) ◽  
pp. 27-34 ◽  
Author(s):  
F Satoh ◽  
K Takahashi ◽  
O Murakami ◽  
K Totsune ◽  
M Ohneda ◽  
...  
Keyword(s):  
Adrenal Gland ◽  
Human Brain ◽  
Northern Blot ◽  
Blot Analysis ◽  
Northern Blot Analysis ◽  
Adrenal Glands ◽  
Adrenocortical Adenoma ◽  
Adrenal Tumour ◽  
Wet Weight ◽  
The Brain

Abstract The expression of cerebellin and cerebellin mRNA was studied by radioimmunoassay and Northern blot analysis in the human brain, adrenal gland and the tumour tissues of adrenal tumour, ganglioneuroblastoma and neuroblastoma. Immunoreactive cerebellin was detected in every region of brain studied, with the highest concentrations found in the hemisphere of the cerebellum (424·2 ± 12·6 pmol/g wet weight, n=6, mean ± s.e.m.) and the vermis of the cerebellum (256·8 ± 30·5 pmol/g wet weight). Immuno-reactive cerebellin was also detected in the pituitary (8·2 ± 1·8 pmol/g wet weight), the spinal cord (3·3 ± 0·3 pmol/g wet weight) and the normal parts of adrenal glands (2·98 ± 0·37 pmol/g wet weight, n=9) and some tumour tissues, such as phaeochromocytomas, cortisol-producing adrenocortical adenomas, ganglioneuroblastomas and neuroblastomas. Northern blot analysis showed that cerebellin mRNA was highly expressed in the hemisphere and vermis of the cerebellum. Cerebellin mRNA was also expressed in other regions of the brain and the tumour tissues of phaeochromocytoma, cortisol-producing adrenocortical adenoma, ganglioneuroblastoma and neuroblastoma. Immunocytochemistry of the normal adrenal gland showed that immunoreactive cerebellin was localized in the adrenal medulla. The present study has shown the expression of cerebellin and cerebellin mRNA, not only in the cerebellum but also in other regions of the brain and some tumours, such as cortisol-producing adrenocortical adenoma, phaeochromocytoma and neuroblastoma. These findings suggest possible pathophysiological roles of cerebellin peptides, not only in the cerebellum, but also in the extra-cerebellar tissues. Journal of Endocrinology (1997) 154, 27–34

Ultrastructural Cytopiasmic Changes of Adrenal Cortex During Pregnancy

1969 ◽  
Vol 27 ◽  
pp. 298-299
Author(s):  
T. M. Murad ◽  
Karen Israel ◽  
Jack C. Geer
Keyword(s):  
Adrenal Gland ◽  
Steroid Hormones ◽  
Adrenal Cortex ◽  
Lipid Droplets ◽  
Plasma Cholesterol ◽  
Adrenal Steroids ◽  
Dynamic Changes ◽  
Cortical Cells ◽  
Acetyl Coenzyme A ◽  
Adrenal Cortical Cells

Adrenal steroids are normally synthesized from acetyl coenzyme A via cholesterol. Cholesterol is also shown to enter the adrenal gland and to be localized in the lipid droplets of the adrenal cortical cells. Both pregnenolone and progesterone act as intermediates in the conversion of cholesterol into steroid hormones. During pregnancy an increased level of plasma cholesterol is known to be associated with an increase of the adrenal corticoid and progesterone. The present study is designed to demonstrate whether the adrenal cortical cells show any dynamic changes during pregnancy.

An adrenocortical oncocytoma with unusual mitochondrial inclusions and cytoplasmic crystals

1994 ◽  
Vol 52 ◽  
pp. 250-251
Author(s):  
W.T. Gunning ◽  
G.D. Haselhuhn ◽  
E.R. Phillips ◽  
S.H. Selman
Keyword(s):  
Adrenal Gland ◽  
Salivary Glands ◽  
Mitotic Activity ◽  
Diagnostic Criteria ◽  
Vascular Invasion ◽  
Benign Neoplasm ◽  
Benign Tumors ◽  
Nuclear Morphology ◽  
Case Presentation ◽  
Microscopic Evidence

Within the last few years, adrenal cortical tumors with features concordant with the diagnostic criteria attributed to oncocytomas have been reported. To date, only nine reported cases exist in the literature. This report is the tenth case presentation of a presumptively benign neoplasm of the adrenal gland with a rare differentiation. Oncocytomas are well recognized benign tumors of the thyroid, parathyroid, and salivary glands and of the kidney. Other organs also give rise to these types of tumors, however with less frequency than the former sites. The characteristics generally used to classify a tumor as an oncocytoma include the following criteria: the tumor is 1) usually a solitary circumscribed mass with no gross nor microscopic evidence of metastasis (no tissue nor vascular invasion), 2) fairly bland in terms of mitotic activity and nuclear morphology, and 3) composed of large eosinophillic cells in which the cytoplasm is packed full of mitochondria (Figure 1).

Contribution of Adrenaline to the Fibrinolytic Activity Evoked by E. Coli Endotoxin in the Rat

1983 ◽  
Vol 50 (02) ◽  
pp. 557-559 ◽  
Author(s):  
J F Fracasso ◽  
A M Rothschild
Keyword(s):  
Fatty Acid ◽  
Adrenal Gland ◽  
Intravenous Injection ◽  
Fibrinolytic Activity ◽  
Blocking Agent ◽  
E Coli ◽  
Adrenergic Blocking

SummaryIntravenous injection of E. coli endotoxin (ETX), of adrenaline (AD) or of carbamylcholine (CBCH), caused fibrinolytic activity (FA), directly detectable on plasminogen-rich fibrin plates, to appear in the plasma of the rat. Adrenodemedul- lation abolished responses to ETX or CBCH, but enhanced those to AD. Rats given ETX exhibited marked hypotension, followed by a compensatory phase of normotension abolished by adrenodemedullation and significantly attenuated by phenoxy- benzamine, an a-adrenergic blocking agent which however failed to block FA caused by either ETX or AD. Aspirin, but not indomethacin, inhibited FA evoked by ETX, AD or CBCH. These results suggest that FA evoked by ETX in the rat is caused by AD released from the adrenal gland and does involve the fatty acid cyclooxygenase system.

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