Absence of Lipoprotein in Pulmonary Œdema Fluid produced by Cytotoxic Antibody

L. S. KIND; A. T. SMITH; P. ELLMAN

doi:10.1038/2011237a0

Pulmonary oedema fluid induces non‐α‐ENaC‐dependent Na + transport and fluid absorption in the distal lung

The Journal of Physiology ◽

10.1113/jphysiol.2002.024612 ◽

2002 ◽

Vol 544 (2) ◽

pp. 537-548 ◽

Cited By ~ 37

Author(s):

Bijan Rafii ◽

Daniel J. Gillie ◽

Chris Sulowski ◽

Vicky Hannam ◽

Tony Cheung ◽

...

Keyword(s):

Pulmonary Oedema ◽

Fluid Absorption ◽

Na Transport ◽

Distal Lung ◽

Oedema Fluid

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Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio

European Respiratory Journal ◽

10.1183/09031936.00098709 ◽

2009 ◽

Vol 35 (2) ◽

pp. 331-337 ◽

Cited By ~ 37

Author(s):

L. B. Ware ◽

R. D. Fremont ◽

J. A. Bastarache ◽

C. S. Calfee ◽

M. A. Matthay

Keyword(s):

Pulmonary Oedema ◽

Plasma Protein ◽

Protein Ratio ◽

Oedema Fluid

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Protein concentration in pulmonary oedema fluid for negative pressure pulmonary oedema in children

Pediatric Anesthesia ◽

10.1046/j.1460-9592.2000.00484.x ◽

2000 ◽

Vol 10 (5) ◽

pp. 557-558 ◽

Cited By ~ 8

Author(s):

J.M. Devys ◽

P. Cadi ◽

Y. Nivoche

Keyword(s):

Pulmonary Oedema ◽

Negative Pressure ◽

Protein Concentration ◽

Negative Pressure Pulmonary Oedema ◽

Oedema Fluid

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Assessment of a Novel Method for Non-invasive Sampling of the Distal Airspace in Acute Respiratory Distress Syndrome Patients Receiving Inhaled Sedation with Sevoflurane: the ANAISS Study Protocol

10.1101/2020.10.05.20207217 ◽

2020 ◽

Author(s):

Pierre-Antoine Tronche ◽

Robin Lalande ◽

Raiko Blondonnet ◽

Laurence Roszyk ◽

Ruoyang Zhai ◽

...

Keyword(s):

Acute Respiratory Distress Syndrome ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Pulmonary Oedema ◽

Study Protocol ◽

Distress Syndrome ◽

Non Invasive ◽

Tnf Α ◽

Distal Airspace ◽

Oedema Fluid

ABSTRACTIntroductionRecently, fluid collected from the heat-and-moisture-exchange filters, which are commonly used in most mechanically ventilated patients under intravenous sedation, has been reported as a potential surrogate for fluid in the distal airspace. Therefore, collection of this fluid represents a promising, non-invasive method for sampling the distal airspace in patients with acute respiratory distress syndrome (ARDS) and for facilitating a mechanistic understanding of this devastating disease. The current study protocol was constructed to assess whether this fluid could be sampled from a dedicated device (Anaesthetic Conserving Device [AnaConDa-S], Sedana Medical, Danderyd, Sweden) used to deliver inhaled sevoflurane for sedation in patients with ARDS.Methods and analysisA total of 30 adult patients within 24 hours of meeting the Berlin criteria for moderate-severe ARDS and receiving inhaled sevoflurane as standard sedation in participating centres will be eligible for inclusion into this investigator-initiated, exploratory, prospective, bicentre study. After at least 12 h of inhaled sedation, a sample of directly aspirated, undiluted pulmonary oedema fluid will be collected concurrently with fluid from the AnaConDa-S device. Levels of proinflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α and sTNFr-1) and markers of lung endothelial (Ang-2) and epithelial (sRAGE) injury will be measured in both fluids by Multiplex. The primary endpoint is the correlation between protein markers (IL-1β, IL-6, IL-8, TNF-α, sTNFr-1, Ang-2 and sRAGE) measured in the undiluted pulmonary oedema fluid versus the AnaConDa-S fluid.Ethics and disseminationThe study was approved by the appropriate ethics committee (CPP Est I). Informed consent is required. The fluid collection from the AnaConDa-S has potential to foster our understanding of the potential effects of inhaled sedation in clinical ARDS and to open up novel perspectives for prognostic and predictive enrichment in future trials. The results will be published in a peer-reviewed journal.Registration numberNCT03964155.

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