scholarly journals Fluorometric Analysis of Amidase and Alkaline Phosphatase in Neonatal Rat Thymocytes : Peak Activities at Two Days of Age

Nature ◽  
1964 ◽  
Vol 201 (4923) ◽  
pp. 1001-1003 ◽  
Author(s):  
LEONARD J. GREENBERG ◽  
LEONARD J. COLE
Keyword(s):  
Alkaline Phosphatase ◽  
Neonatal Rat ◽  
Fluorometric Analysis

Deficiency of intestinal alkaline phosphatase in newborns predisposes to necrotizing enterocolitis in a neonatal rat model

2011 ◽  
Vol 213 (3) ◽  
pp. S85
Author(s):  
Rebecca M. Rentea ◽  
Jill S. Whitehouse ◽  
Jennifer L. Liedel ◽  
Kirkwood A. Pritchard ◽  
Alan N. Mayer ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Necrotizing Enterocolitis ◽  
Rat Model ◽  
Neonatal Rat ◽  
Intestinal Alkaline Phosphatase ◽  
Neonatal Rat Model

Effect of Diisononyl Phtalate on Disaccharidase and Alkaline Phosphatase in Neonatal Rat

2016 ◽  
Vol 33 (S 01) ◽  
Author(s):  
K. Ahmed ◽  
O. Kharoubi ◽  
A. Aoues ◽  
M. Bouchkara ◽  
M. Taleb ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Neonatal Rat

Ag-Ion-Modified Au Nanoclusters for Fluorometric Analysis of Alkaline Phosphatase

2020 ◽  
Vol 3 (6) ◽  
pp. 6034-6042 ◽  
Author(s):  
Mengke Wang ◽  
Shun Wang ◽  
Xiaoming Xie ◽  
Xingguang Su
Keyword(s):  
Alkaline Phosphatase ◽  
Au Nanoclusters ◽  
Fluorometric Analysis

Factors Known to Influence the Development of Necrotizing Enterocolitis to Modify Expression and Activity of Intestinal Alkaline Phosphatase in a Newborn Neonatal Rat Model

2018 ◽  
Vol 29 (03) ◽  
pp. 290-297 ◽  
Author(s):  
Rebecca Rentea ◽  
Matthea Rentea ◽  
Ben Biesterveld ◽  
Jennifer Liedel ◽  
David Gourlay
Keyword(s):  
Alkaline Phosphatase ◽  
Necrotizing Enterocolitis ◽  
Rat Model ◽  
Therapeutic Benefit ◽  
Formula Feeding ◽  
Neonatal Rat ◽  
Sprague Dawley ◽  
Intestinal Alkaline Phosphatase ◽  
Neonatal Rat Model ◽  
Expression And Activity

Introduction Prematurity, formula feeding, and early weaning strongly influence enterocyte differentiation. Intestinal alkaline phosphatase (IAP), an endogenous protein expressed in the intestines, is one enzyme that is affected by these factors. IAP supplementation decreases the severity of necrotizing enterocolitis (NEC) injury. We, therefore, hypothesized that prematurity predisposes this population to NEC due to IAP deficiency and investigated IAP expression and function in a neonatal rat model. Materials and Methods Pre- and full-term newborn Sprague-Dawley rat pups were sacrificed on consecutive days of life both after vaginal or cesarean birth and following either breast or formula feeding. Results Compared with controls, cesarean delivery and formula feeding are associated with lower levels of IAP. The formula-fed pups continued to have low baseline IAP activity. Neither prematurity nor formula feeding led to differences of intestinal injury. Conclusion Prematurity and formula feeding are associated with inhibition of IAP expression and activity. Both may increase the risk of NEC and early enteral supplementation of IAP to newborns at risk of NEC may be of therapeutic benefit.

Regulation of alkaline phosphatase expression in a neonatal rat clonal calvarial cell strain by retinoic acid

2009 ◽  
Vol 3 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Kong Wah Ng ◽  
Paul R. Gummer ◽  
Valdo P. Michelangeli ◽  
John F. Bateman ◽  
Thomas Mascara ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Retinoic Acid ◽  
Cell Strain ◽  
Neonatal Rat ◽  
Alkaline Phosphatase Expression

Cytochemical Evidence for Presynatic β-Adrenergic Regulation of Secretion in the Developing Rat Submandibular Gland

1977 ◽  
Vol 35 ◽  
pp. 430-431
Author(s):  
L.S. Cutler
Keyword(s):  
Cyclic Amp ◽  
Adenylate Cyclase ◽  
Submandibular Gland ◽  
Neonatal Rat ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Parotid Glands ◽  
Adrenergic Agonist ◽  
Rat Submandibular Gland

Many studies previously have shown that the B-adrenergic agonist isoproterenol and the a-adrenergic agonist norepinephrine will stimulate secretion by the adult rat submandibular (SMG) and parotid glands. Recent data from several laboratories indicates that adrenergic agonists bind to specific receptors on the secretory cell surface and stimulate membrane associated adenylate cyclase activity which generates cyclic AMP. The production of cyclic AMP apparently initiates a cascade of events which culminates in exocytosis. During recent studies in our laboratory it was observed that the adenylate cyclase activity in plasma membrane fractions derived from the prenatal and early neonatal rat submandibular gland was retractile to stimulation by isoproterenol but was stimulated by norepinephrine. In addition, in vitro secretion studies indicated that these prenatal and neonatal glands would not secrete peroxidase in response to isoproterenol but would secrete in response to norepinephrine. In contrast to these in vitro observations, it has been shown that the injection of isoproterenol into the living newborn rat results in secretion of peroxidase by the SMG (1).

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