Effect of Cholesterol Oleate on the Phagocytic Function of the Reticulo-Endothelial System

Nature ◽  
1962 ◽  
Vol 196 (4849) ◽  
pp. 78-79 ◽  
Author(s):  
A. E. STUART
Keyword(s):  
Phagocytic Function ◽  
Reticulo Endothelial System

Erythrophagocytosis in the Liver in Hemolytic Anemias

1968 ◽  
Vol 26 ◽  
pp. 184-185
Author(s):  
O. T. Minick ◽  
E. Orfei ◽  
F. Volini ◽  
G. Kent
Keyword(s):  
Acid Phosphatase ◽  
Oxidative Damage ◽  
Phosphatase Activity ◽  
Kupffer Cells ◽  
Acid Phosphatase Activity ◽  
Common Type ◽  
Red Cell ◽  
Cell Fragments ◽  
Reticulo Endothelial System ◽  
Important Site

Hemolytic anemias were produced in rats by administering phenylhydrazine or anti-erythrocytic (rooster) serum, the latter having agglutinin and hemolysin titers exceeding 1:1000.Following administration of phenylhydrazine, the erythrocytes undergo oxidative damage and are removed from the circulation by the cells of the reticulo-endothelial system, predominantly by the spleen. With increasing dosage or if animals are splenectomized, the Kupffer cells become an important site of sequestration and are greatly hypertrophied. Whole red cells are the most common type engulfed; they are broken down in digestive vacuoles, as shown by the presence of acid phosphatase activity (Fig. 1). Heinz body material and membranes persist longer than native hemoglobin. With larger doses of phenylhydrazine, erythrocytes undergo intravascular fragmentation, and the particles phagocytized are now mainly red cell fragments of varying sizes (Fig. 2).

Impaired phagocytic function and increased immune complexes in diabetics with severe microangiopathy

Diabetes ◽  
1982 ◽  
Vol 31 (1) ◽  
pp. 7-11 ◽  
Author(s):  
M. Iavicoli ◽  
U. Di Mario ◽  
P. Pozzilli ◽  
J. Canalese ◽  
L. Ventriglia ◽  
...  
Keyword(s):  
Immune Complexes ◽  
Phagocytic Function

scholarly journals The inflammatory response induced by Pseudomonas aeruginosa in macrophages enhances apoptotic cell removal

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Adriana Valeria Jäger ◽  
Paula Arias ◽  
Maria Virginia Tribulatti ◽  
Marcela Adriana Brocco ◽  
Maria Victoria Pepe ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Pseudomonas Aeruginosa ◽  
Inflammatory Response ◽  
Apoptotic Cell ◽  
Bacterial Pathogen ◽  
Environmental Cues ◽  
Apoptotic Cells ◽  
Phagocytic Function ◽  
Inflammatory Stimulus ◽  
Inflammatory Conditions

AbstractPathogens phagocytosis and the uptake of apoptotic cells (efferocytosis) are essential macrophages tasks, classically considered as mutually exclusive. Macrophages have been observed to polarize into either pro-inflammatory/microbicidal or anti-inflammatory/efferocytic phenotypes. However, macrophage functions have shown to be more complex. Furthermore, little is known about the regulation of efferocytosis under inflammatory conditions. In this study, we elucidate the modulation of the macrophage efferocytic function during an inflammatory stimulus. We find that bone marrow-derived macrophages (BMDM) are very efficient in engulfing both the bacterial pathogen Pseudomonas aeruginosa and apoptotic cells. BMDM showed a high bactericidal capacity unaffected by the concomitant presence of apoptotic material. Plasticity in macrophage programming, in response to changing environmental cues, may modulate efferocytic capability. In this work, we further show that, after phagocyting and processing Pseudomonas aeruginosa, macrophages highly increase their efferocytic capacity without affecting their phagocytic function. Moreover, we demonstrate that Pseudomonas aeruginosa enhances efferocytosis of these phagocytes through the IL-6 signaling pathway. Our results show that the inflammatory response generated by the bacterial processing enhances these macrophages’ capacity to control inflammation through an increased efferocytosis.

scholarly journals Effect of Antibiotics on the Phagocytic Activity of the Reticulo-Endothelial System

Nature ◽  
1958 ◽  
Vol 181 (4624) ◽  
pp. 1662-1662 ◽  
Author(s):  
I. A. SEWELL ◽  
T. NICOL
Keyword(s):  
Phagocytic Activity ◽  
Reticulo Endothelial System

Sodium molybdate improves the phagocytic function in alloxan-induced diabetic rats

2003 ◽  
Vol 145 (2) ◽  
pp. 159-163 ◽  
Author(s):  
Saraswathi Panneerselvam ◽  
Swaminathan Govindasamy
Keyword(s):  
Sodium Molybdate ◽  
Diabetic Rats ◽  
Phagocytic Function

PHAGOCYTIC FUNCTION OF ALVEOLAR MACROPHAGES DURING OPEN HEART SURGERY

1994 ◽  
Vol 81 (SUPPLEMENT) ◽  
pp. A245 ◽  
Author(s):  
N. Kotani ◽  
H. Hashimoto ◽  
J. S. Wang ◽  
C. Y. Lin ◽  
M. F. Roizen
Keyword(s):  
Alveolar Macrophages ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Phagocytic Function
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