Enzyme Histochemistry of Bronchial Epithelium and Alveolar Cells in the Early Stages of Influenza-Virus Pneumonia of Mice

Nature ◽  
1962 ◽  
Vol 193 (4813) ◽  
pp. 348-349 ◽  
Author(s):  
J. F. Ph. HERS ◽  
R. G. J. WILLIGHAGEN ◽  
D. A. J. TYRRELL ◽  
LIDY van der KUIP ◽  
MARIA A. C. HOS
Keyword(s):  
Influenza Virus ◽  
Enzyme Histochemistry ◽  
Bronchial Epithelium ◽  
Alveolar Cells ◽  
Early Stages ◽  
Virus Pneumonia

Combined Effect of Influenza Virus Infection and Urethan Treatment on the Incidence of Lung: Tumors in Mice.

1965 ◽  
Vol 51 (6) ◽  
pp. 401-417 ◽  
Author(s):  
Anna Maria Casazza ◽  
Marcello Gaetani ◽  
Mario Ghione ◽  
Enrico Turolla
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Joint Action ◽  
Influenza A ◽  
Influenza Virus Infection ◽  
Alveolar Epithelium ◽  
Bronchial Epithelium ◽  
Lung Tumors ◽  
Pulmonary Tissue ◽  
Two Agents

Swiss mice were intranasally infected with influenza A2 virus and treated with urethan in order to detect whether the joint action of the two agents would enhance the development of lung tumors. The average number per mouse of the typical lesions induced by the two treatments together with their location, their histological and histochemical characteristics and the percentage of death in the different groups of animals were recorded. Results indicated that 51.7 % of the mice infected with influenza virus and treated with urethan had both bronchial dysplastic lesions due to influenza virus, and tumors induced by urethan. In this group the number of tumors was smaller than in the mice treated with the carcinogen only and no invasive pulmonary carcinomas were observed. The dysplastic lesions caused by influenza A2 virus as well as the lung adenomas induced by urethan maintained their typical histological and histochemical characteristics even when occurring in a close position. The failure of urethan to enhance the induction of lung tumors in mice exposed to influenzal infection might be ascribed to the different primary sites of response of the pulmonary tissue to the two agents, i.e. the bronchial epithelium for influenza virus and the alveolar epithelium for urethan.

IFN-γ Treatment at Early Stages of Influenza Virus Infection Protects Mice from Death in a NK Cell-Dependent Manner

2010 ◽  
Vol 30 (6) ◽  
pp. 439-449 ◽  
Author(s):  
Ido D. Weiss ◽  
Ori Wald ◽  
Hanna Wald ◽  
Katia Beider ◽  
Michal Abraham ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Nk Cell ◽  
Influenza Virus Infection ◽  
Dependent Manner ◽  
Early Stages ◽  
Ifn Γ

scholarly journals Administration of isoferulic acid improved the survival rate of lethal influenza virus pneumonia in mice

2001 ◽  
Vol 10 (2) ◽  
pp. 93-96 ◽  
Author(s):  
Shinya Sakai ◽  
Hiroshi Ochiai ◽  
Naoki Mantani ◽  
Toshiaki Kogure ◽  
Naotoshi Shibahara ◽  
...  
Keyword(s):  
Body Weight ◽  
Influenza Virus ◽  
Survival Rate ◽  
Inflammatory Diseases ◽  
Dose Range ◽  
Body Weight Loss ◽  
Ether Anesthesia ◽  
Immune Effector ◽  
Virus Pneumonia ◽  
Isoferulic Acid

Background: Isoferulic acid (IFA) is a main active ingredient of the rhizoma ofCimicifuga heracleifolia, which is used frequently in Japanese traditional medicine as an anti-inflammatory drug. It has been revealed that IFA inhibits the production of macrophage inflammatory protein-2 (MIP-2), which is a murine counterpart of the chemokine family that may contribute to the pathogenesis of inflammatory diseases through the chemotactic activity for inflammatory and immune effector cells.Aim of the study: In this study, we investigated the therapeutic effect of IFA on the progression of lethal influenza virus pneumonia in mice by comparison with that of dexamethasone (DX), a potent inhibitor for various inflammatory cytokines including MIP-2.Methods: Mice were infected by intranasal inoculation of influenza virus under ether anesthesia. The IFA or DX was given by oral administration once daily for 4 days after infection. After infection, the survival rate and the change in body weight were daily monitored.Results: IFA administration markedly improved the survival rate and body weight loss of influenza virusinfected mice in a suitable dose range (0.5 mg/day). However, DX administration did not show a beneficial effect at any dose.Conclusion: These data suggested that IFA is a novel tool not only for the intervention therapy, but also for the studies on the pathogenesis of influenza virusinduced pneumonia.

scholarly journals Correction: Macrophage-expressed IFN-β Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia

2016 ◽  
Vol 12 (6) ◽  
pp. e1005716 ◽  
Author(s):  
Katrin Högner ◽  
Thorsten Wolff ◽  
Stephan Pleschka ◽  
Stephanie Plog ◽  
Achim D. Gruber ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Epithelial Cell ◽  
Cell Injury ◽  
Alveolar Epithelial Cell ◽  
Alveolar Epithelial ◽  
Severe Influenza ◽  
Virus Pneumonia ◽  
Epithelial Cell Injury

scholarly journals Radiomics Is Effective for Distinguishing Coronavirus Disease 2019 Pneumonia From Influenza Virus Pneumonia

2021 ◽  
Vol 9 ◽  
Author(s):  
Liaoyi Lin ◽  
Jinjin Liu ◽  
Qingshan Deng ◽  
Na Li ◽  
Jingye Pan ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Characteristic Curve ◽  
Operator Method ◽  
Training Sample ◽  
Receiver Operator Characteristic Curve ◽  
Stepwise Logistic Regression ◽  
Data Sets ◽  
Validation Data ◽  
Virus Pneumonia ◽  
Selection Operator

Objectives: To develop and validate a radiomics model for distinguishing coronavirus disease 2019 (COVID-19) pneumonia from influenza virus pneumonia.Materials and Methods: A radiomics model was developed on the basis of 56 patients with COVID-19 pneumonia and 90 patients with influenza virus pneumonia in this retrospective study. Radiomics features were extracted from CT images. The radiomics features were reduced by the Max-Relevance and Min-Redundancy algorithm and the least absolute shrinkage and selection operator method. The radiomics model was built using the multivariate backward stepwise logistic regression. A nomogram of the radiomics model was established, and the decision curve showed the clinical usefulness of the radiomics nomogram.Results: The radiomics features, consisting of nine selected features, were significantly different between COVID-19 pneumonia and influenza virus pneumonia in both training and validation data sets. The receiver operator characteristic curve of the radiomics model showed good discrimination in the training sample [area under the receiver operating characteristic curve (AUC), 0.909; 95% confidence interval (CI), 0.859–0.958] and in the validation sample (AUC, 0.911; 95% CI, 0.753–1.000). The nomogram was established and had good calibration. Decision curve analysis showed that the radiomics nomogram was clinically useful.Conclusions: The radiomics model has good performance for distinguishing COVID-19 pneumonia from influenza virus pneumonia and may aid in the diagnosis of COVID-19 pneumonia.

Germacrone inhibits early stages of influenza virus infection

2013 ◽  
Vol 100 (3) ◽  
pp. 578-588 ◽  
Author(s):  
Qingjiao Liao ◽  
Zhengxu Qian ◽  
Rui Liu ◽  
Liwei An ◽  
Xulin Chen
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
Early Stages

scholarly journals Macrophage-expressed IFN-β Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia

2013 ◽  
Vol 9 (2) ◽  
pp. e1003188 ◽  
Author(s):  
Katrin Högner ◽  
Thorsten Wolff ◽  
Stephan Pleschka ◽  
Stephanie Plog ◽  
Achim D. Gruber ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Epithelial Cell ◽  
Cell Injury ◽  
Alveolar Epithelial Cell ◽  
Alveolar Epithelial ◽  
Severe Influenza ◽  
Virus Pneumonia ◽  
Epithelial Cell Injury

scholarly journals Mouse Models Reveal Role of T-Cytotoxic and T-Reg Cells in Immune Response to Influenza: Implications for Vaccine Design

Viruses ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 52 ◽  
Author(s):  
Stewart Sell ◽  
Karl McKinstry ◽  
Tara Strutt
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Influenza Virus ◽  
Epithelial Cells ◽  
Mouse Models ◽  
Viral Infections ◽  
Influenza Virus Infection ◽  
Bronchial Epithelium ◽  
Cytotoxic Cells ◽  
Type Ii Pneumocytes

Immunopathologic examination of the lungs of mouse models of experimental influenza virus infection provides new insights into the immune response in this disease. First, there is rapidly developing perivascular and peribronchial infiltration of the lung with T-cells. This is followed by invasion of T-cells into the bronchiolar epithelium, and separation of epithelial cells from each other and from the basement membrane leading to defoliation of the bronchial epithelium. The intraepithelial reaction may involve either CD8 or CD4 T-cytotoxic cells and is analogous to a viral exanthema of the skin, such as measles and smallpox, which occur when the immune response against these infections is activated and the infected cells are attacked by T-cytotoxic cells. Then there is formation of B-cell follicles adjacent to bronchi, i.e., induced bronchial associated lymphoid tissue (iBALT). iBALT reacts like the cortex of a lymph node and is a site for a local immune response not only to the original viral infection, but also related viral infections (heterologous immunity). Proliferation of Type II pneumocytes and/or terminal bronchial epithelial cells may extend into the adjacent lung leading to large zones filled with tumor-like epithelial cells. The effective killing of influenza virus infected epithelial cells by T-cytotoxic cells and induction of iBALT suggests that adding the induction of these components might greatly increase the efficacy of influenza vaccination.

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