Hormonal Induction of Alkaline Phosphatase in Human Cells in Tissue Culture

Nature ◽  
1961 ◽  
Vol 190 (4770) ◽  
pp. 85-87 ◽  
Author(s):  
BODY P. COX ◽  
COLIN M. MACLEOD
Keyword(s):  
Tissue Culture ◽  
Alkaline Phosphatase ◽  
Human Cells ◽  
Hormonal Induction

Distribution of Alkaline Phosphatase Variants in a Heteroploid Strain of Human Cells in Tissue Culture

Nature ◽  
1962 ◽  
Vol 196 (4854) ◽  
pp. 600-601 ◽  
Author(s):  
JOSEPH J. MAIO ◽  
LUIGI L. DE CARLI
Keyword(s):  
Tissue Culture ◽  
Alkaline Phosphatase ◽  
Human Cells

Number of nucleoli in female and male human cells in tissue culture

1962 ◽  
Vol 28 (3) ◽  
pp. 590-592 ◽  
Author(s):  
G.B. Petersen ◽  
A.J. Therkelsen
Keyword(s):  
Tissue Culture ◽  
Human Cells

Studies on the Mechanism of Substrate Induction and L-Cyst(e)ine Repression of Alkaline Phosphatase in Mammalian Cell Cultures

1967 ◽  
Vol 2 (4) ◽  
pp. 545-555
Author(s):  
M. J. GRIFFIN ◽  
R. P. COX
Keyword(s):  
Tissue Culture ◽  
Alkaline Phosphatase ◽  
Cell Cultures ◽  
Phosphate Esters ◽  
Kidney Cell Line ◽  
Monkey Kidney Cell ◽  
African Green Monkey Kidney ◽  
Mammalian Cell Cultures ◽  
Green Monkey ◽  
Substrate Induction

The mechanisms of substrate induction and L-cyst(e)ine repression of alkaline phosphatase were studied in tissue culture using an established African green monkey kidney cell line (BS-C-I). L-Cyst(e)ine repression and substrate induction are mutually antagonistic. Evidence is presented which suggests that the increase in alkaline phosphatase levels induced by mono-phosphate esters may in part be due to protection of the enzyme from cellular degradation, while L-cyst(e)ine is believed to act either by repressing the synthesis of the enzyme or by selectively increasing its catabolism.

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