Importance of Insulin and of the Adrenal Cortex in determining the Toxicity in Baboons (Papio ursinus) of Human Anterior Pituitary

Nature ◽  
1960 ◽  
Vol 188 (4753) ◽  
pp. 861-862
Author(s):  
JOSEPH GILLMAN ◽  
CHRISTINE GILBERT ◽  
EDWARD EPSTEIN
1947 ◽  
Vol 168 (2) ◽  
pp. 583-596
Author(s):  
Sidney P. Colowick ◽  
Gerty T. Cori ◽  
Milton W. Slein

1991 ◽  
Vol 81 (s25) ◽  
pp. 29P-30P
Author(s):  
SL Atkin ◽  
AM Landolt ◽  
RV Jeffreys ◽  
White MC

1970 ◽  
Vol 48 (4) ◽  
pp. 639-647 ◽  
Author(s):  
PATRICIA M. NICHOLSON

SUMMARY Polyacrylamide disc gel electrophoresis of aqueous extracts of individual human anterior pituitary glands failed to identify a protein with lactogenic activity which was characteristic of pregnancy and the post-partum period. Lactogenic activity, determined by a semi-quantitative rabbit mammary gland organ culture assay, was largely associated with the growth hormone fraction. The total prolactin activity of individual anterior pituitary glands was determined by a 'local' intradermal pigeon crop sac method. The glands from pregnant and parturient women did not contain a higher concentration of prolactin than those of men or non-pregnant non-lactating women. These results do not provide any evidence for the existence of a human pituitary prolactin distinct from growth hormone. Reasons for this are discussed.


1957 ◽  
Vol 189 (1) ◽  
pp. 11-14 ◽  
Author(s):  
E. Irene Pentz ◽  
Robert J. Hasterlik

An immediate diuresis has been observed in rats exposed to total-body x-irradiation ranging between 100 and 400 r. Since the highest dosage produced more consistent results, it was used in conjunction with extirpation of various glands and other organs in an effort to determine the mechanism that responds so promptly to x-irradiation. The anterior pituitary and the adrenal cortex are of prime importance in this reaction. Removal of the anterior lobe of the pituitary or removal of the adrenal glands is sufficient to completely inhibit diuresis following 400 r x-irradiation. This diuretic response is not dependent upon the presence of the posterior pituitary since animals having only this gland removed became diuretic following exposure to 400 r. The evidence suggests that the release of antidiuretic substances from tissues other than the posterior pituitary is under anterior pituitary-adrenal cortical control.


1994 ◽  
Vol 424 (1) ◽  
Author(s):  
M.R. Farnoud ◽  
F. Peillon ◽  
J.Y. Li ◽  
M. Kujas ◽  
J. Racadot ◽  
...  

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