Structure of a Melanocyte-Stimulating Hormone from the Human Pituitary Gland

Nature ◽  
1959 ◽  
Vol 184 (4681) ◽  
pp. 167-169 ◽  
Author(s):  
J. IEUAN HARRIS
Keyword(s):  
Pituitary Gland ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Melanocyte Stimulating Hormone ◽  
Stimulating Hormone

Localization of the aromatase enzyme expression in the human pituitary gland and its effect on growth hormone, prolactin, and thyroid stimulating hormone axis

Endocrine ◽  
2015 ◽  
Vol 49 (3) ◽  
pp. 761-768 ◽  
Author(s):  
Asli Sezgin Caglar ◽  
Aysegul Kapucu ◽  
Kadriye Akgun Dar ◽  
Hande Mefkure Ozkaya ◽  
Erkan Caglar ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Gland ◽  
Thyroid Stimulating Hormone ◽  
Enzyme Expression ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Effect On Growth ◽  
Stimulating Hormone

Demonstration of desacetyl α-melanocyte-stimulating hormone in fetal and adult human anterior pituitary corticotrophs

1989 ◽  
Vol 120 (3) ◽  
pp. 525-NP ◽  
Author(s):  
P. J. Coates ◽  
I. Doniach ◽  
J. M. P. Holly ◽  
L. H. Rees
Keyword(s):  
Pituitary Gland ◽  
High Performance ◽  
Anterior Lobe ◽  
Pars Intermedia ◽  
Intermediate Lobe ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Melanocyte Stimulating Hormone ◽  
Pars Anterior ◽  
Human Anterior Pituitary

ABSTRACT Immunocytochemistry, radioimmunoassay and high-performance liquid chromatography (HPLC) techniques have been used in combination to investigate the presence of immunoreactive (ir)-α-MSH in the normal human pituitary gland, and to investigate the possible origin of these cells from the fetal pars intermedia. Two separate antisera to α-MSH were employed in immunocytochemistry to distinguish between authentic α-MSH and the desacetyl form. Only desacetyl α-MSH was detected in the pituitary gland of fetal and adult man, in both the pars (zona) intermedia and the pars anterior. In the fetus, a large proportion of the ACTH-containing cells of the anterior lobe also contained ir-α-MSH, while ir-α-MSH containing cells were more sparse in adults. Radioimmunoassay of acid extracts of adult pituitary tissue showed α-MSH levels representing less than 0·05% of the ACTH content of the gland. HPLC analysis of these extracts confirmed that only the desacetyl form was present. These results suggest that α-MSH peptides are synthesized by anterior lobe cells of the human pituitary gland, which are not derived from the fetal pars intermedia. Possible regulatory mechanisms affecting cells which contain ir-α-MSH are discussed, and by comparison with the intermediate lobe of other species it is concluded that there is little evidence for a true intermediate lobe in the human pituitary gland. Journal of Endocrinology (1989) 120, 525–530

The corticotrophic cells of the canine pituitary gland in pituitary-dependent hyperadrenocorticism

1983 ◽  
Vol 96 (2) ◽  
pp. 303-309 ◽  
Author(s):  
A. M. McNicol ◽  
H. Thomson ◽  
C. J. R. Stewart
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pituitary Gland ◽  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Single Entity ◽  
Pituitary Glands ◽  
Corticotrophic Cells

The distribution of specifically stained corticotrophic cells has been studied in the pituitary glands of 11 dogs with pituitary-dependent hyperadrenocorticism. The results suggest that the disease is not a single entity, and that some cases are caused by primary abnormality of the pituitary gland whereas others appear to be the result of dysfunction of the hypothalamus or central nervous system. The patterns correspond closely to those demonstrated in the human pituitary gland in Cushing's disease, and confirm that the canine disease is a useful model for the study of the pathogenesis of the variants of the condition.

Isolation of five active thyrotropin components from human pituitary gland

1975 ◽  
Vol 379 (1) ◽  
pp. 247-261 ◽  
Author(s):  
Paul Roos ◽  
D.V. Dervartanian ◽  
Gunilla Jacobson ◽  
Leif Wide
Keyword(s):  
Pituitary Gland ◽  
Human Pituitary ◽  
Human Pituitary Gland

The Presence, Characterisation and Synthesis of Neuromedin B in the Human Pituitary Gland

1992 ◽  
Vol 56 (5) ◽  
pp. 729-734 ◽  
Author(s):  
Solange C. Hearn ◽  
Philip M. Jones ◽  
Mohammad A. Ghatei ◽  
Johanna Byrne ◽  
Sarah F. Hill ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Neuromedin B
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