Apparent Reciprocal Exchange of Characters between the Mel and NWS Strains of Influenza A Virus in the Brain of One-day Old Mice

K. B. FRASER

doi:10.1038/176212a0

Impaired Microglial Activation in the Brain of IL-18-Gene-Disrupted Mice after Neurovirulent Influenza A Virus Infection

Virology ◽

10.1006/viro.2001.1029 ◽

2001 ◽

Vol 287 (1) ◽

pp. 163-170 ◽

Cited By ~ 38

Author(s):

Isamu Mori ◽

Md.Jaber Hossain ◽

Kiyoshi Takeda ◽

Haruki Okamura ◽

Yoshinori Imai ◽

...

Keyword(s):

Virus Infection ◽

Influenza A Virus ◽

Influenza A ◽

Microglial Activation ◽

Influenza A Virus Infection ◽

The Brain

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Acute Encephalopathy Associated with Influenza A Virus Infection

Clinical Infectious Diseases ◽

10.1086/367623 ◽

2003 ◽

Vol 36 (5) ◽

pp. 567-574 ◽

Cited By ~ 76

Author(s):

Christoph Steininger ◽

Theresia Popow-Kraupp ◽

Hermann Laferl ◽

Andreas Seiser ◽

Irene Gödl ◽

...

Keyword(s):

Influenza A Virus ◽

Influenza A ◽

Respiratory Illness ◽

Magnetic Resonance Images ◽

High Signal ◽

Acute Encephalopathy ◽

Highly Sensitive ◽

Sensitive Polymerase Chain Reaction ◽

Polymerase Chain ◽

The Brain

Abstract Twenty-one patients aged 4–78 years with influenza A virus–associated acute encephalopathy were studied. Influenza A virus could be detected only in a cerebrospinal fluid (CSF) specimen obtained from 1 of 18 patients, despite the use of a highly sensitive polymerase chain reaction assay. Six patients experienced influenzal encephalopathy during the course of respiratory illness. Five of these patients had hypoprothrombinemia and 4 had increased serum creatinine levels, indicating hepatic and/or renal dysfunction. Fourteen patients experienced postinfluenzal encephalopathy ⩽3 weeks after resolution of acute respiratory symptoms. In 6 patients, focal areas of high signal intensity were visible on T2-weighted magnetic resonance images of the brain. Adenovirus DNA was detected in CSF specimens obtained from 4 (36%) of 11 patients with postinfluenzal encephalopathy. Thus, influenzal encephalopathy is frequently associated with metabolic disorders, whereas postinfluenzal encephalopathy appears to have different possible etiologies.

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Impaired phagocytic function in CX3CR1 + tissue‐resident skeletal muscle macrophages prevents muscle recovery after influenza A virus‐induced pneumonia in old mice

Aging Cell ◽

10.1111/acel.13180 ◽

2020 ◽

Vol 19 (9) ◽

Author(s):

Constance E. Runyan ◽

Lynn C. Welch ◽

Emilia Lecuona ◽

Masahiko Shigemura ◽

Luciano Amarelle ◽

...

Keyword(s):

Skeletal Muscle ◽

Influenza A Virus ◽

Influenza A ◽

Phagocytic Function ◽

Muscle Recovery ◽

Old Mice

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Influenza A Virus Mediated Downregulation of Progesterone Receptor Membrane Component-1 Inhibits RIG-I-dependent Antiviral Response in Central Nervous System

10.21203/rs.3.rs-90902/v1 ◽

2020 ◽

Author(s):

Kun Huang ◽

Yufei Zhang ◽

Wenxiao Gong ◽

Yong Yang ◽

Lili Jiang ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Progesterone Receptor ◽

Influenza A Virus ◽

Influenza A ◽

Rna Seq ◽

Membrane Component ◽

Receptor Membrane ◽

The Central Nervous System ◽

The Brain

Abstract Background: The influenza A virus (IAV) enters the central nervous system (CNS) via multiple routes and causes neurological symptoms. In this process, it develops multiple strategies to escape the host anti-viral immune system, and infects the central nervous system (CNS). Progesterone receptor membrane component-1 (PGRMC1) is highly expressed in the CNS, where it exerts a neurotrophic effect. However, how PGRMC1 affects IAV remains unclear.Methods: In this study, we aimed to investigate the role of PGRMC1 in regulating antiviral defense response in brain tissue. Toward this, we used both mouse model of IAV infection and the human neuroblastoma cell line SK-N-SH and human brain glioma cell line U251 . High-throughput RNA sequencing (RNA-seq) was used to obtain an unbiased profile of the cellular response to IAV H5N6 infection in mice brain. Results: Here, RNA-seq revealed 240 differentially expressed genes in the IAV-infected brains. Among the significantly down-regulated genes, we focused on the gene encoding progesterone receptor membrane component-1 (PGRMC1) and observed that IAV H5N6 infection clearly inhibited PGRMC1 in both neuroblastoma and glioma cells. Furthermore, treatment with AG205, a PGRMC1-specific inhibitor, or PGRMC1 knockout promoted H5N6 multiplication in vitro, while overexpression of PGRMC1 resulted in opposite effects. Furthermore, AG205 treatment or PGRMC1 knockout significantly inhibited RIG-I-mediated IFN-β signaling pathway and reduced the levels of several antiviral proteins (Mx1 and ISG15). In addition, PGRMC1-mediated regulation of IFN signaling relied on inhibition of the expression and ubiquitination of RIG-I.Conclusion: Conclusively, our results show for the first time that IAV H5N6 down-regulates PGRMC1 expression to contribute to virus proliferation by inhibiting RIG-I-mediated IFN-β production in the brain. These findings may offer new insights regarding the interplay between IAV and host factors that may impact IAV pathogenicity in the brain.

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