Natural and Synthetic Drugs

Nature ◽  
1951 ◽  
Vol 168 (4272) ◽  
pp. 438-439
Author(s):  
J. W. COOK
Keyword(s):  
Synthetic Drugs ◽  
Natural And Synthetic

Natural and synthetic drugs used for the treatment of the dementia

2020 ◽  
Vol 524 (3) ◽  
pp. 772-783 ◽  
Author(s):  
Valery M. Dembitsky ◽  
Lilya Dzhemileva ◽  
Tatyana Gloriozova ◽  
Vladimir D’yakonov
Keyword(s):  
Synthetic Drugs ◽  
Natural And Synthetic

Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host

2007 ◽  
Vol 146 (4) ◽  
pp. 601-620 ◽  
Author(s):  
Juan Diego Maya ◽  
Bruce K. Cassels ◽  
Patricio Iturriaga-Vásquez ◽  
Jorge Ferreira ◽  
Mario Faúndez ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Mode Of Action ◽  
Mammalian Host ◽  
Synthetic Drugs ◽  
Natural And Synthetic

The Synthesis and Chemistry of Quinolinediones and their Carbocyclic Analogs

2021 ◽  
Vol 18 ◽  
Author(s):  
Samuel Attah Egu ◽  
Efeturi Abraham Onoabedje ◽  
Uchechukwu Chris Okoro ◽  
Khalid Mohammed Khan ◽  
Abdul Hameed ◽  
...  
Keyword(s):  
Antineoplastic Agents ◽  
Radical Scavenging ◽  
Research Articles ◽  
Industrial Chemicals ◽  
Synthetic Drugs ◽  
Natural And Synthetic

: Quinoline-5,8-dione and naphthoquinone nuclei are very important substructures in industrial chemicals and pharmaceuticals. These compounds exhibit a wide variety of activities, including activity as antifungal, antibacterial, antimalarial, antineoplastic, anticoagulant, anticancer, antiviral, radical scavenging, antiplatelet, trypanocidal, cytotoxic and antineoplastic agents. Currently, several research articles about the importance of many natural and synthetic drugs containing quinolinequinone have been reported. This review covers the progress in quinolinequinone and naphthoquinone chemistry over the last five decades.

scholarly journals Advanced Bioinformatics Tools in the Pharmacokinetic Profiles of Natural and Synthetic Compounds with Anti-Diabetic Activity

Biomolecules ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1692
Author(s):  
Ana Maria Udrea ◽  
Gratiela Gradisteanu Pircalabioru ◽  
Anca Andreea Boboc ◽  
Catalina Mares ◽  
Andra Dinache ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Quantitative Structure Activity Relationship ◽  
Major Health Problem ◽  
Synthetic Compounds ◽  
Synthetic Drugs ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Bioinformatics Tools ◽  
Sugar Levels ◽  
Natural And Synthetic

Diabetes represents a major health problem, involving a severe imbalance of blood sugar levels, which can disturb the nerves, eyes, kidneys, and other organs. Diabes management involves several synthetic drugs focused on improving insulin sensitivity, increasing insulin production, and decreasing blood glucose levels, but with unclear molecular mechanisms and severe side effects. Natural chemicals extracted from several plants such as Gymnema sylvestre, Momordica charantia or Ophiopogon planiscapus Niger have aroused great interest for their anti-diabetes activity, but also their hypolipidemic and anti-obesity activity. Here, we focused on the anti-diabetic activity of a few natural and synthetic compounds, in correlation with their pharmacokinetic/pharmacodynamic profiles, especially with their blood-brain barrier (BBB) permeability. We reviewed studies that used bioinformatics methods such as predicted BBB, molecular docking, molecular dynamics and quantitative structure-activity relationship (QSAR) to elucidate the proper action mechanisms of antidiabetic compounds. Currently, it is evident that BBB damage plays a significant role in diabetes disorders, but the molecular mechanisms are not clear. Here, we presented the efficacy of natural (gymnemic acids, quercetin, resveratrol) and synthetic (TAK-242, propofol, or APX3330) compounds in reducing diabetes symptoms and improving BBB dysfunctions. Bioinformatics tools can be helpful in the quest for chemical compounds with effective anti-diabetic activity that can enhance the druggability of molecular targets and provide a deeper understanding of diabetes mechanisms.

The study of NMR spectroscopy use in pharmaceutical analysis

2021 ◽  
pp. 73-78
Author(s):  
Maria N. Kuznetsova ◽  
Vera Yu. Zhilkina
Keyword(s):  
Quality Assurance ◽  
Nmr Spectroscopy ◽  
Pharmaceutical Analysis ◽  
Drug Products ◽  
Synthetic Drugs ◽  
Highly Active ◽  
Drugs Analysis ◽  
Active Substances ◽  
Natural And Synthetic

Drug products are specific goods. A customer cannot determine quality and authenticity of any tablet, ointment or ampule content himself. As number of registered drugs has been increasing the actuality of quality assurance and standardization of drugs becomes much important. At the same time highly active substances belonging to new natural and synthetic drugs classes has been coming in medicinal practice. NMR spectroscopy approach has wide opportunities in increasing number of drugs analysis which must meet constantly increasing demands.

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