Handbook of Chemical Microscopy

doi:10.1038/149593a0

Chemical microscopy of some toxicologically important alkaloids

Microchimica Acta ◽

10.1007/bf01417570 ◽

1939 ◽

Vol 27 (4) ◽

pp. 249-334 ◽

Cited By ~ 13

Author(s):

W. F. Whitmore ◽

C. A. Wood

Keyword(s):

Chemical Microscopy

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Chemical microscopy

Analytical Chemistry ◽

10.1021/ac60369a021 ◽

1976 ◽

Vol 48 (5) ◽

pp. 333-340 ◽

Cited By ~ 2

Author(s):

George G. Cocks

Keyword(s):

Chemical Microscopy

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Simultaneously detection two types of ions using THz chemical microscopy

10.1109/cleopr.2015.7376395 ◽

2015 ◽

Author(s):

Kosuke Akimune ◽

Yuki Okawa ◽

Kenji Sakai ◽

Toshihiko Kiwa ◽

Keiji Tsukada

Keyword(s):

Chemical Microscopy

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Chemical Microscopy of Urinary Calculi.

Analytical Chemistry ◽

10.1021/ac60230a028 ◽

1965 ◽

Vol 37 (11) ◽

pp. 1399-1404 ◽

Cited By ~ 3

Author(s):

D. E. Laskowski

Keyword(s):

Urinary Calculi ◽

Chemical Microscopy

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Organic chemical microscopy. Part VI. p-toluidides and amides as qualitative organic derivatives of carboxylic acids

Microchemical Journal ◽

10.1016/0026-265x(59)90080-3 ◽

1959 ◽

Vol 3 (4) ◽

pp. 491-505 ◽

Cited By ~ 11

Author(s):

Ralph E. Dunbar ◽

Cyril C. Moore

Keyword(s):

Carboxylic Acids ◽

Organic Chemical ◽

Derivatives Of ◽

Chemical Microscopy

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Polymorphism of pharmaceuticals

Polymorphism in Molecular Crystals ◽

10.1093/oso/9780199655441.003.0007 ◽

2020 ◽

pp. 342-375

Author(s):

Joel Bernstein

Keyword(s):

Ionic Liquids ◽

Pharmaceutical Preparations ◽

Phase Changes ◽

New Techniques ◽

Solvent Selection ◽

Crystal Forms ◽

Rate Of Dissolution ◽

Amorphous Forms ◽

Stable Forms ◽

Chemical Microscopy

Chapter 7 deals with polymorphism in pharmaceuticals. Following a discussion of the problem of determining the statistics of the occurrence of polymorphism in pharmaceuticals, I present a discussion and examples of the connection between polymorphism and the rate of dissolution and solubility, bioavailability, and the importance of phase changes and mixtures of forms in pharmaceutical preparations. I survey some of the considerations and techniques involved in screening for crystal forms: solvent selection, specific screening for solvates and hydrates, gel crystallization, crystallization in ionic liquids, the challenge of difficult to obtain stable forms and unstable new forms, and the outlook on new techniques and conditions for crystallization. The chapter also deals with polymorphism in pharmaceutical co-crystals, excipients, and amorphous forms and the importance and utility of chemical microscopy in the study of polymorphism of pharmaceuticals.

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