Calcium channel activation stabilizes a neuronal calcium channel mRNA

10.1038/12153 ◽  
1999 ◽  
Vol 2 (9) ◽  
pp. 785-790 ◽  
Author(s):  
Stephanie Schorge ◽  
Seema Gupta ◽  
Zhixin Lin ◽  
Maureen W. McEnery ◽  
Diane Lipscombe
Keyword(s):  
Calcium Channel ◽  
Channel Activation ◽  
Neuronal Calcium Channel

State-Dependent Nickel Block of a High-Voltage–Activated Neuronal Calcium Channel

1998 ◽  
Vol 80 (4) ◽  
pp. 1678-1685 ◽  
Author(s):  
Matthew B. McFarlane ◽  
William F. Gilly
Keyword(s):  
Calcium Channel ◽  
High Voltage ◽  
Cell Voltage ◽  
Open Channels ◽  
Giant Fiber ◽  
Channel Activation ◽  
Nickel Ions ◽  
State Dependent ◽  
Wide Range ◽  
Neuronal Calcium Channel

McFarlane, Matthew B. and William F. Gilly. State-dependent nickel block of a high-voltage–activated neuronal calcium channel. J. Neurophysiol. 80: 1678–1685, 1998. Effects of nickel ions (Ni2+) on noninactivating calcium channels in squid giant fiber lobe (GFL) neurons were investigated with whole cell voltage clamp. Three different effects of Ni2+ were observed to be associated with distinct Ca2+ channel activation states. 1) Nickel ions appear to stabilize closed channel states and, as a result, slow activation kinetics. 2) Nickel ions block open channels with little voltage dependence over a wide range of potentials. 3) Block of open channels by Ni2+ becomes more effective during an extended strong depolarization, and this effect is voltage dependent. Recovery from this additional inhibition occurs at intermediate voltages, consistent with the presence of two distinct types of Ni2+ block that we propose correspond to two previously identified open states of the calcium channel. These results, taken together with earlier evidence of state-dependent block by ω-agatoxin IVA, suggest that Ni2+ generates these unique effects in part by interacting differently with the external surface of the GFL calcium channel complex in ways that depend on channel activation state.

scholarly journals Neuronal calcium channel inhibitors. Synthesis of omega-conotoxin GVIA and effects on 45Ca uptake by synaptosomes.

1987 ◽  
Vol 262 (3) ◽  
pp. 1194-1198
Author(s):  
J Rivier ◽  
R Galyean ◽  
W R Gray ◽  
A Azimi-Zonooz ◽  
J M McIntosh ◽  
...  
Keyword(s):  
Calcium Channel ◽  
45Ca Uptake ◽  
Calcium Channel Inhibitors ◽  
Neuronal Calcium Channel

Neuronal calcium channel autoantibodies coexisting with type 1 Purkinje cell cytoplasmic autoantibodies (PCA-1 or "anti-Yo")

Neurology ◽  
1998 ◽  
Vol 51 (1) ◽  
pp. 328-329
Author(s):  
K. Tanaka ◽  
M. Motomura ◽  
Y. Nakao ◽  
M. Tanaka ◽  
S. Tsuji
Keyword(s):  
Purkinje Cell ◽  
Calcium Channel ◽  
Neuronal Calcium Channel

scholarly journals L-type calcium channel activation controls the in vivo transduction of the neuralizing signal in the amphibian embryos

1997 ◽  
Vol 64 (1-2) ◽  
pp. 105-110 ◽  
Author(s):  
Catherine Leclerc ◽  
Christiane Daguzan ◽  
Marie-Thérèse Nicolas ◽  
Claude Chabret ◽  
Anne-Marie Duprat ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Channel Activation ◽  
Amphibian Embryos

scholarly journals Novel ω-Conotoxins fromConus catusDiscriminate among Neuronal Calcium Channel Subtypes

2000 ◽  
Vol 275 (45) ◽  
pp. 35335-35344 ◽  
Author(s):  
Richard J. Lewis ◽  
Katherine J. Nielsen ◽  
David J. Craik ◽  
Marion L. Loughnan ◽  
Denise A. Adams ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Neuronal Calcium Channel
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