Psychological symptoms and perceived cognitive impairment in multiple sclerosis: The role of rumination.

2018 ◽  
Vol 63 (2) ◽  
pp. 286-294 ◽  
Author(s):  
Bailee L. Malivoire ◽  
Crystal J. Hare ◽  
Tae L. Hart
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Psychological Symptoms

scholarly journals Lack of Association betweenPRNPM129V Polymorphism and Multiple Sclerosis, Mild Cognitive Impairment, Alcoholism and Schizophrenia in a Korean Population

2010 ◽  
Vol 28 (5) ◽  
pp. 315-321 ◽  
Author(s):  
Ihn-Geun Choi ◽  
Sung-Il Woo ◽  
Ho Jin Kim ◽  
Dai-Jin Kim ◽  
Byung Lae Park ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Genetic Association ◽  
Prion Diseases ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Korean Population ◽  
Weak Influence

The genetic variant at codon 129 (M129V) of the prion protein gene (PRNP) is considered to be a major genetic risk factor for prion diseases. In this study, we examined the possible genetic association ofPRNP*129Valwith multiple sclerosis (MS,n= 681), mild cognitive impairment (MCI,n= 801), alcoholism (n= 761) and schizophrenia (n= 715) in a Korean population, and compared the data with previous genetic association studies of the variant. The minor allele frequency ofPRNP*129Val(MAF = 0.025) was significantly lower in Korean population (n= 2,479) compared to Caucasian populations (P< 0.0001), suggestive of a weak influence of the variant in the previous population. Statistical analysis revealed no significant association betweenPRNP*129Valand MS (P = 0.76), MCI (P = 0.46), alcoholism (P = 0.84) and schizophrenia (P = 0.69). These findings were discussed in the context of prior inconsistent reports on the role ofPRNP*129Valpolymorphism in several diseases. Results from this study may provide further evidence thatPRNP M129Vis not a genetic susceptibility factor for MS, MCI, alcoholism and schizophrenia in a Korean population.

scholarly journals Intracortical lesions by 3T magnetic resonance imaging and correlation with cognitive impairment in multiple sclerosis

2011 ◽  
Vol 17 (9) ◽  
pp. 1122-1129 ◽  
Author(s):  
Flavia Nelson ◽  
Sushmita Datta ◽  
Nereyda Garcia ◽  
Nigel L Rozario ◽  
Francisco Perez ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Magnetic Resonance ◽  
Cognitive Status ◽  
Inversion Recovery ◽  
Cortical Lesions ◽  
Resonance Imaging

Background: Accurate classification of multiple sclerosis (MS) lesions in the brain cortex may be important in understanding their impact on cognitive impairment (CI). Improved accuracy in identification/classification of cortical lesions was demonstrated in a study combining two magnetic resonance imaging (MRI) sequences: double inversion recovery (DIR) and T1-weighted phase-sensitive inversion recovery (PSIR). Objective: To evaluate the role of intracortical lesions (IC) in MS-related CI and compare it with the role of mixed (MX), juxtacortical (JX), the sum of IC + MX and with total lesions as detected on DIR/PSIR images. Correlations between CI and brain atrophy, disease severity and disease duration were also sought. Methods: A total of 39 patients underwent extensive neuropsychological testing and were classified into normal and impaired groups. Images were obtained on a 3T scanner and cortical lesions were assessed blind to the cognitive status of the subjects. Results: Some 238 cortical lesions were identified (130 IC, 108 MX) in 82% of the patients; 39 JX lesions were also identified. Correlations between CI and MX lesions alone ( p = 0.010) and with the sum of IC + MX lesions ( p = 0.030) were found. A correlation between severity of CI and Expanded Disability Status Scale was also seen ( p = 0.009). Conclusion: Cortical lesions play an important role in CI. However, our results suggest that lesions that remain contained within the cortical ribbon do not play a more important role than ones extending into the adjacent white matter; furthermore, the size of the cortical lesion, and not the tissue-specific location, may better explain their correlation with CI.

Screening for Cognitive Impairment in Patients with Multiple Sclerosis: Role of Patient Reported Outcomes

2014 ◽  
Vol 95 (10) ◽  
pp. e37
Author(s):  
Sonya Kim ◽  
Vance Zemon ◽  
Mary Ann Picone ◽  
Joseph F. Rath ◽  
Elizabeth S. Gromisch ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Patient Reported Outcomes ◽  
Patient Reported

scholarly journals The Brain-Derived Neurotrophic Factor Val66Met Polymorphism Can Protect Against Cognitive Impairment in Multiple Sclerosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Emilio Portaccio ◽  
Angelo Bellinvia ◽  
Elio Prestipino ◽  
Benedetta Nacmias ◽  
Silvia Bagnoli ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Neurotrophic Factor ◽  
Multivariable Analysis ◽  
Brain Derived Neurotrophic Factor ◽  
Bdnf Expression ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism ◽  
Edss Score

Introduction: Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family, involved in neuronal survival and synaptic plasticity. The BDNF Val66Met polymorphism is known to reduce BDNF expression and secretion; its role in multiple sclerosis (MS) is poorly investigated.Objectives and Methods: In this multicenter, retrospective study, we assessed the role of BDNF Val66Met polymorphism on cognitive and motor disability in MS patients consecutively referred to the University of Florence and the Hospital of Barletta. All patients underwent a genetic analysis for the presence of Val66Met polymorphism and a comprehensive neuropsychological examination on the Rao's Brief Repeatable Battery and the Stroop Color Word Test. Possible predictors of the Expanded Disability Status Scale (EDSS) score and number of failed neuropsychological tests were assessed through linear multivariable regression models.Results: Ninety-eight patients were recruited. Patients with the BDNF Val66Met polymorphism (35.7%) were more frequently males (p = 0.020), more disabled (p = 0.026) and, marginally, older (p = 0.064). In the multivariable analysis, BDNF Val66Met polymorphism was associated with a better cognitive performance (B = −1.1 ± 0.5, p = 0.027). Higher EDSS score was associated with a progressive disease course (B = 3.4, p &lt; 0.001) and, marginally, with the presence of the BDNF Val66Met polymorphism (B = 0.56, p = 0.066).Discussion: Our results preliminarily suggest a protective role of BDNF Val66Met polymorphism against cognitive impairment in MS patients, possibly related to a detrimental effect of increased BDNF concentration in a neuroinflammatory environment.

scholarly journals The Diagnostic Role of Brain MRI in Detection of Multiple Sclerosis Related Cognitive Impairment

2019 ◽  
Vol 09 (08) ◽  
pp. 313-324
Author(s):  
Mohamed Saad ◽  
Maha Bilal ◽  
Wael Gabr ◽  
Aymen Abd Elnaby
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Brain Mri ◽  
Diagnostic Role
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