Episodic memory in normal and pathological aging at the RAVLT Test: Comparisons of immediate and delayed recall.

2021 ◽  
Author(s):  
Bruna Fulgencio Dias ◽  
Maria Aparecida Camargos Bicalho ◽  
Mônica Vieira Costa ◽  
Rafaela Teixeira de Ávila ◽  
Leandro Fernandes Malloy-Diniz ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Delayed Recall ◽  
Pathological Aging

scholarly journals Delayed recall memory impairment in patients with Parkinson's disease

2016 ◽  
Vol 10 (3) ◽  
pp. 204-209 ◽  
Author(s):  
Arthur Oscar Schelp ◽  
Cristiane Lara Mendes-Chiloff ◽  
Vanessa Cristina Paduan ◽  
José Eduardo Corrente ◽  
Fabrício Diniz de Lima ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Episodic Memory ◽  
Memory Impairment ◽  
Rating Scale ◽  
Demographic Variables ◽  
Delayed Recall ◽  
Recall Memory ◽  
Significant Difference ◽  
With Memory

ABSTRACT Age is one of the risk factors for dementia in patients with Parkinson's disease (PDD). Distinct cognitive syndromes of Parkinson's disease (PD) have been identified in previous studies. Questions about the role of such cognitive disorders in PD outcomes, especially memory dysfunction, in patients with PD remain unanswered. Objective: To establish possible correlations between delayed recall memory (episodic memory), age, and other demographic variables in patients with PD. Methods: A two-stage protocol was applied. Patients with delayed recall memory compromise, selected based on a brief battery of tests (BBRC-Edu), were classified as dementia cases and submitted to the Mattis Dementia Rating Scale (MDRS). Data from patients with memory disturbances were compared against individuals without episodic memory impairment, and correlated with age and demographic variables. Results: Except for identification and naming, all subtests in the screening battery showed a significant difference (p≤0.0001) between the memory-compromised group (case) and the group without memory impairment (no case). The results also correlated negatively with age (p≤0.0001) and positively with level of education (p=0.0874) in patients with PD. Conclusion: The analysis showed a significant relationship between age and dementia characterized by impaired episodic memory. The findings support reports of a wide spectrum of neuropsychological performance impairment in PD with age, particularly dementia associated with memory deterioration. No correlations between disease duration and cognitive dysfunction were evident.

scholarly journals Musical instrument engagement across the life course and episodic memory in late life: An analysis of 60 years of longitudinal data from the Wisconsin Longitudinal Study

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0253053
Author(s):  
Jamie L. Romeiser ◽  
Dylan M. Smith ◽  
Sean A. P. Clouston
Keyword(s):  
High School ◽  
Episodic Memory ◽  
Cognitive Reserve ◽  
High School Graduates ◽  
Musical Instrument ◽  
Delayed Recall ◽  
Memory Decline ◽  
Musical Engagement ◽  
Rate Of Decline ◽  
Over Time

Background As the global burden of dementia increases, the absence of treatment underscores the need for identification of factors that may improve cognitive reserve–the ability to stave off cognitive decline in old age. The beneficial association between musical instrument engagement and episodic memory has been identified in children, young adults, and older adults. Yet, previous studies in musical instrument engagement have rarely examined the potential for adolescence and adulthood exposures to independently improve cognition, nor have they been linked with the rate of memory decline over time in older adults. We investigated whether adolescent musical instrument engagement and continued musical instrument engagement over the adult life course were separately associated with higher episodic memory, as well as rate of decline in a large longitudinal cohort. Methods Data were from a prospective cohort of high school graduates from 1957. High school music engagement (HSME) was ascertained through graduate yearbooks and assessed as membership in musical performance groups. A questionnaire was used to assess musical engagement through adulthood (MEA) at ages 35, 55, and 65. The episodic memory score was composed of immediate and delayed recall task scores, and was assessed when participants were aged approximately 65 and 72 years old among 5,718 individuals. Linear mixed models were used to assess the association between music, and memory performance and decline over time. Results Of high school graduates who participated in the study, 38.1% played music in high school, and 21.1% played music in adulthood. While musical engagement was more common in those who played in childhood, 40% of those who played continuously as an adult did not play in high school. High HSME (B = 0.348, p = 0.049) and continuous MEA (B = 0.424, p = 0.012) were associated with higher memory scores at age 65 after covariate adjustment. When examining memory decline, the benefits of high HSME decreased over time (B = -0.435, p = 0.048), while the rate of decline did not differ between MEA groups. Exploratory models revealed differential benefits for HSME and immediate recall, and MEA and delayed recall. Conclusion This study provides further evidence that musical engagement in childhood or adulthood is associated with non-musical cognitive reserve. These two exposures may act differentially in different domains of episodic memory. Further work is needed to determine the relationship between musicianship and the rate of cognitive decline.

scholarly journals Genetic architecture of learning and delayed recall: A twin study of episodic memory.

2011 ◽  
Vol 25 (4) ◽  
pp. 488-498 ◽  
Author(s):  
Matthew S. Panizzon ◽  
Michael J. Lyons ◽  
Kristen C. Jacobson ◽  
Carol E. Franz ◽  
Michael D. Grant ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Twin Study ◽  
Genetic Architecture ◽  
Delayed Recall

scholarly journals Alpha peak frequency is linked to episodic memory impairment in pathological aging

2021 ◽  
Author(s):  
Delphine Puttaert ◽  
Vincent Wens ◽  
Patrick Fery ◽  
Antonin Rovai ◽  
Nicola Trotta ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Resting State ◽  
Early Stage ◽  
Brain Activity ◽  
Peak Frequency ◽  
Short Term ◽  
Slowing Down ◽  
Pathological Aging ◽  
18Fdg Pet ◽  
Alpha Peak

The Free and Cued Selective Reminding Test (FCSRT) is a largely validated neuropsychological test for the identification of amnestic syndrome from the early stage of Alzheimers disease (AD). Previous electrophysiological data suggested a slowing down of the alpha rhythm in the AD-continuum as well as a key role of this rhythmic brain activity for episodic memory processes. This study therefore investigates the link between alpha brain activity and alterations in episodic memory as assessed by the FCSRT. For that purpose, 37 patients with altered FCSRT performance underwent a comprehensive neuropsychological assessment, supplemented by 18F-fluorodeoxyglucose positron emission tomography/structural magnetic resonance imaging (18FDG-PET/MR), and 10 minutes of resting-state magnetoencephalography (MEG). The individual alpha peak frequency (APF) in MEG resting-state data was positively correlated with patients encoding efficiency as well as with the efficacy of semantic cues in facilitating patients retrieval of previous stored word. The APF also correlated positively with patients hippocampal volume and their regional glucose consumption in the posterior cingulate cortex. Overall, this study demonstrates that alterations in the ability to learn and store new information for a relatively short-term period are related to a slowing down of alpha rhythmic activity, possibly due to altered interactions in the extended mnemonic system. As such, a decreased APF may be considered as an electrophysiological correlate of short-term episodic memory dysfunction accompanying pathological aging.

scholarly journals Plasma MCP-1 and changes on cognitive function in community-dwelling older adults

2022 ◽  
Vol 14 (1) ◽  
Author(s):  
Juan Luis Sanchez-Sanchez ◽  
Kelly V. Giudici ◽  
Sophie Guyonnet ◽  
Julien Delrieu ◽  
Yan Li ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Episodic Memory ◽  
Cognitive Decline ◽  
Continuous Variable ◽  
Community Dwelling ◽  
Clinical Dementia Rating ◽  
Delayed Recall ◽  
Domain Specific

Abstract Background Monocyte Chemoattractant Protein-1 (MCP-1), a glial-derived chemokine, mediates neuroinflammation and may regulate memory outcomes among older adults. We aimed to explore the associations of plasma MCP-1 levels (alone and in combination with β-amyloid deposition—Aβ42/40) with overall and domain-specific cognitive evolution among older adults. Methods Secondary analyses including 1097 subjects (mean age = 75.3 years ± 4.4; 63.8% women) from the Multidomain Alzheimer Preventive Trial (MAPT). MCP-1 (higher is worse) and Aβ42/40 (lower is worse) were measured in plasma collected at year 1. MCP-1 in continuous and as a dichotomy (values in the highest quartile (MCP-1+)) were used, as well as a dichotomy of Aβ42/40. Outcomes were measured annually over 4 years and included the following: cognitive composite z-score (CCS), the Mini-Mental State Examination (MMSE), and Clinical Dementia Rating (CDR) sum of boxes (overall cognitive function); composite executive function z-score, composite attention z-score, Free and Cued Selective Reminding Test (FCSRT - memory). Results Plasma MCP-1 as a continuous variable was associated with the worsening of episodic memory over 4 years of follow-up, specifically in measures of free and cued delayed recall. MCP-1+ was associated with worse evolution in the CCS (4-year between-group difference: β = −0.14, 95%CI = −0.26, −0.02) and the CDR sum of boxes (2-year: β = 0.19, 95%CI = 0.06, 0.32). In domain-specific analyses, MCP-1+ was associated with declines in the FCSRT delayed recall sub-domains. In the presence of low Aβ42/40, MCP-1+ was not associated with greater declines in cognitive functions. The interaction with continuous biomarker values Aβ42/40× MCP-1 × time was significant in models with CDR sum of boxes and FCSRT DTR as dependent variables. Conclusions Baseline plasma MCP-1 levels were associated with longitudinal declines in overall cognitive and episodic memory performance in older adults over a 4-year follow-up. How plasma MCP-1 interacts with Aβ42/40 to determine cognitive decline at different stages of cognitive decline/dementia should be clarified by further research. The MCP-1 association on cognitive decline was strongest in those with amyloid plaques, as measured by blood plasma Aβ42/40.

scholarly journals Verbal Episodic Memory and Endogenous Estradiol: An Association in Patients with Mild Cognitive Impairment and Alzheimer's Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
D. M. Bittner ◽  
V. Bittner ◽  
M. W. Riepe
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Episodic Memory ◽  
Verbal Memory ◽  
Delayed Recall ◽  
Apoe Phenotype ◽  
Normal Controls ◽  
Verbal Episodic Memory

In the continuum of patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and normal controls, a possible association of verbal memory and endogenous estradiol (E2) levels was investigated. Verbal episodic memory was measured with a german version of the California verbal memory test (CVLT). Results were controlled for apolipoprotein E (ApoE) phenotype. We studied 37 controls, 32 MCIs and 117 ADs. Groups differed in all trials of the CVLT and in E2levels . E2 levels differed significantly between groups only among females . In females correcting for age and ApoE, there was an overall correlation between CVLT delayed recall and level of E2  . Stepwise regression analyses found E2level to be a significant predictor for CVLT delayed recall . It may be concluded that lower E2levels occur more in the course of the disease than may be considered as a risk factor per se.

scholarly journals Transcranial direct current stimulation (tDCS). An effective tool for improving episodic memory in young people?

2021 ◽  
Vol 37 (3) ◽  
pp. 468-477
Author(s):  
Alba Fernández ◽  
Susana Cid-Fernández ◽  
Fernando Díaz
Keyword(s):  
Episodic Memory ◽  
Memory Performance ◽  
Memory Task ◽  
Controlled Study ◽  
Anodal Tdcs ◽  
Post Intervention ◽  
Double Blind ◽  
Delayed Recall ◽  
Healthy Elderly ◽  
Main Effects

El objetivo principal del presente estudio fue determinar los efectos de la tDCS anódica vs placebo, administrada sobre el dlPFC durante la fase de codificación de una tarea de memoria episódica, sobre la tasa de aciertos (TA) y el tiempo de reacción (TR) medidos en las fases de recuerdo inmediato y demorado de la tarea, en un grupo de 23 participantes jóvenes sanos. Se realizó un estudio doble ciego aleatorizado. Los resultados evidenciaron efectos principales significativos para los factores Bloque, Sesión y Demora en la TA y en el TR, pero no para el factor del Grupo. Se encontraron efectos robustos de aprendizaje intrasesión e intersesiones, pero ningún efecto Grupo (tDCS anódica vs placebo) en el rendimiento de la memoria episódica o en los tests neuropsicológicos pre-post intervención. Sin embargo, los participantes que recibieron tDCS anódica mostraron un TR acortado en el intervalo de demora de 24 horas que mantuvieron una semana más tarde, mientras que los que recibieron tDCS placebo no mostraron acortamiento del TR a las 24 horas, pero si un aumento del TR una semana después. Estos resultados podrían indicar un sutil efecto modulador de la tDCS anódica en el decaimiento de la memoria en los intervalos de demora. El protocolo experimental mostró su utilidad potencial para ser utilizado en muestras de participantes mayores sanos o con deterioro cognitivo leve The main aim of the present study was to determine the effects of anodal vs sham tDCS administered over the dlPFC during the encoding phase of an episodic memory task, on the accuracy rate (AR) and reaction time (RT) measured in the immediate and delayed recall phases of the task, in a group of 23 healthy young participants. A randomized double-blind sham-controlled study of tDCS was carried out. The results evidenced significant main effects for factors Block, Session, and Delay on the AR and on RT, but not for the Group factor. Robust intra-session and inter-session learning effects but no Group (anodal vs sham tDCS) effect in episodic memory performance or in pre-post intervention neuropsychological tests were found. However, participants who received anodal tDCS showed shorter RT in the 24 hours delay interval and maintained it one week later, while those who received sham tDCS did not show the 24 hours RT shortening and even showed a RT increase one week later. These results could indicate a subtle modulatory effect of anodal tDCS on memory decay along delay intervals. The experimental protocol showed its potential utility to be used in samples of healthy elderly or mild cognitive impairment participants

scholarly journals Decreased Alpha Peak Frequency Is Linked to Episodic Memory Impairment in Pathological Aging

2021 ◽  
Vol 13 ◽  
Author(s):  
Delphine Puttaert ◽  
Vincent Wens ◽  
Patrick Fery ◽  
Antonin Rovai ◽  
Nicola Trotta ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Resting State ◽  
Early Stage ◽  
Brain Activity ◽  
Peak Frequency ◽  
Posterior Cingulate Cortex ◽  
Short Term ◽  
Slowing Down ◽  
Pathological Aging ◽  
Alpha Peak

The Free and Cued Selective Reminding Test (FCSRT) is a largely validated neuropsychological test for the identification of amnestic syndrome from the early stage of Alzheimer’s disease (AD). Previous electrophysiological data suggested a slowing down of the alpha rhythm in the AD-continuum as well as a key role of this rhythmic brain activity for episodic memory processes. This study therefore investigates the link between alpha brain activity and alterations in episodic memory as assessed by the FCSRT. For that purpose, 37 patients with altered FCSRT performance underwent a comprehensive neuropsychological assessment, supplemented by 18F-fluorodeoxyglucose positron emission tomography/structural magnetic resonance imaging (18FDG-PET/MR), and 10 min of resting-state magnetoencephalography (MEG). The individual alpha peak frequency (APF) in MEG resting-state data was positively correlated with patients’ encoding efficiency as well as with the efficacy of semantic cues in facilitating patients’ retrieval of previous stored word. The APF also correlated positively with patients’ hippocampal volume and their regional glucose consumption in the posterior cingulate cortex. Overall, this study demonstrates that alterations in the ability to learn and store new information for a relatively short-term period are related to a slowing down of alpha rhythmic activity, possibly due to altered interactions in the extended mnemonic system. As such, a decreased APF may be considered as an electrophysiological correlate of short-term episodic memory dysfunction accompanying pathological aging.

scholarly journals Integrity of white matter structure is related to episodic memory performance in the low-educated elderly

2017 ◽  
Vol 75 (11) ◽  
pp. 778-784 ◽  
Author(s):  
Elisa de Paula França Resende ◽  
Fernanda Freire Tovar-Moll ◽  
Fernanda Meireles Ferreira ◽  
Ivanei Bramati ◽  
Leonardo Cruz de Souza ◽  
...  
Keyword(s):  
White Matter ◽  
Episodic Memory ◽  
Diffusion Tensor ◽  
Memory Performance ◽  
Verbal Learning ◽  
Cognitive Screening ◽  
Delayed Recall ◽  
Learning Test ◽  
Low Educated ◽  
The Right

ABSTRACT The low-educated elderly are a vulnerable population in whom studying the role of white matter integrity on memory may provide insights for understanding how memory declines with aging and disease. Methods: Thirty-one participants (22 women), 23 cognitively healthy and eight with cognitive impairment-no dementia, aged 80.4 ± 3.8 years, with 2.2 ± 1.9 years of education, underwent an MRI scan with diffusion tensor imaging (DTI) acquisition. We verified if there were correlations between the performance on the Brief Cognitive Screening Battery (BCSB) and the Rey Auditory Verbal Learning Test (RAVLT) with DTI parameters. Results: The BCSB delayed recall task correlated with frontotemporoparietal connection bundles, with the hippocampal part of the cingulum bilaterally and with the right superior longitudinal fasciculus. The RAVLT learning and delayed recall scores also correlated with the hippocampal part of the cingulum bilaterally. Conclusions: Although preliminary, our study suggests that the integrity of white matter frontotemporoparietal fasciculi seems to play a role in episodic memory performance in the low-educated elderly. This finding opens opportunities to study potential targets for memory decline prevention in vulnerable populations.

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