scholarly journals Translational dynamics of alcohol tolerance of preclinical models and human laboratory studies.

2020 ◽  
Vol 28 (4) ◽  
pp. 417-425
Author(s):  
Carolina L. Haass-Koffler ◽  
Nazzareno Cannella ◽  
Roberto Ciccocioppo
Keyword(s):  
Alcohol Tolerance ◽  
Laboratory Studies ◽  
Preclinical Models ◽  
Human Laboratory

scholarly journals Alcohol Tolerance in Human Laboratory Studies for Development of Medications to treat Alcohol Use Disorder

2020 ◽  
Vol 55 (2) ◽  
pp. 129-135
Author(s):  
Carolina L Haass-Koffler ◽  
Roberta Perciballi
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Motor Impairment ◽  
Alcohol Tolerance ◽  
Subjective Response ◽  
Laboratory Studies ◽  
Phenotypic Profile ◽  
Additional Information ◽  
Research Opportunity ◽  
Human Laboratory

Abstract Aims Human laboratory studies have contributed extensively in the research and development of novel medications to treat alcohol use disorder (AUD). Alcohol tolerance may represent one additional variable that can be utilized to expand the understanding of the AUD wide phenotypic profile and provide support to the medication development process. Tolerance is characterized as an individual’s subjective response to alcohol and has been recognized as a predictor of AUD progression. Tolerance can be evaluated both by self-reported response (e.g. assessments) and objective measurements (e.g. motor impairment); as such, it represents an exploitable variable in the field of alcohol research. Methods This Narrative Review focuses on the use of alcohol tolerance, specifically within alcohol laboratory studies, for medication development. It seeks to identify a research gap and a research opportunity in clinical studies to evaluate biobehavioral responses captured in order to develop medications to treat AUD. Results Alcohol tolerance may provide additional information on the safety and tolerability of medications to treat AUD, in particular, when novel medications are co-administered with alcohol within the AUD population. Conclusions As such, alcohol tolerance represents an additional outcome that may be included in randomized clinical trial (RCT) protocols designed for developing AUD pharmacotherapies.

Methods reporting in human laboratory studies

Addiction ◽  
2013 ◽  
Vol 108 (5) ◽  
pp. 1002-1003 ◽  
Author(s):  
Olivia M. Maynard ◽  
Marcus R. Munafò
Keyword(s):  
Laboratory Studies ◽  
Human Laboratory

scholarly journals Isradipine Decreases the Hemodynamic Response of Cocaine and MethamphetamineResults From Two Human Laboratory Studies

2005 ◽  
Vol 18 (6) ◽  
pp. 813-822 ◽  
Author(s):  
B JOHNSON ◽  
L WELLS ◽  
J ROACHE ◽  
C WALLACE ◽  
N AITDAOUD ◽  
...  
Keyword(s):  
Hemodynamic Response ◽  
Laboratory Studies ◽  
Human Laboratory

scholarly journals Translating preclinical models of alcohol seeking and consumption into the human laboratory using intravenous alcohol self‐administration paradigms

2021 ◽  
Author(s):  
Melissa A. Cyders ◽  
Martin H. Plawecki ◽  
Zachary T. Whitt ◽  
Ann E.K. Kosobud ◽  
David A. Kareken ◽  
...  
Keyword(s):  
Preclinical Models ◽  
Self Administration ◽  
Human Laboratory ◽  
Alcohol Seeking

Human Laboratory Studies of Buprenorphine

1992 ◽  
Author(s):  
Jack H. Mendelson ◽  
Nancy K. Mello
Keyword(s):  
Laboratory Studies ◽  
Human Laboratory
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