Psychological functioning during the COVID-19 lockdown: The role of exposure to continuous traumatic stress in conflict-ridden regions.

2021 ◽  
Author(s):  
Sima Amram-Vaknin ◽  
Yuliya Lipshits-Braziler ◽  
Moshe Tatar
Keyword(s):  
Traumatic Stress ◽  
Psychological Functioning

scholarly journals Genes and hormones of the hypothalamic–pituitary–adrenal axis in post-traumatic stress disorder. What is their role in symptom expression and treatment response?

2021 ◽  
Author(s):  
Susanne Fischer ◽  
Tabea Schumacher ◽  
Christine Knaevelsrud ◽  
Ulrike Ehlert ◽  
Sarah Schumacher
Keyword(s):  
Hpa Axis ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Ptsd Symptoms ◽  
Post Traumatic Stress ◽  
Alternative Treatments ◽  
Hypothalamic Pituitary Adrenal ◽  
Post Traumatic

Abstract Background Less than half of all individuals with post-traumatic stress disorder (PTSD) remit spontaneously and a large proportion of those seeking treatment do not respond sufficiently. This suggests that there may be subgroups of individuals who are in need of augmentative or alternative treatments. One of the most frequent pathophysiological findings in PTSD is alterations in the hypothalamic–pituitary–adrenal (HPA) axis, including enhanced negative feedback sensitivity and attenuated peripheral cortisol. Given the role of the HPA axis in cognition, this pattern may contribute to PTSD symptoms and interfere with key processes of standard first-line treatments, such as trauma-focused cognitive behavioural therapy (TF-CBT). Methods This review provides a comprehensive summary of the current state of research regarding the role of HPA axis functioning in PTSD symptoms and treatment. Results Overall, there is preliminary evidence that hypocortisolaemia contributes to symptom manifestation in PTSD; that it predicts non-responses to TF-CBT; and that it is subject to change in parallel with positive treatment trajectories. Moreover, there is evidence that genetic and epigenetic alterations within the genes NR3C1 and FKBP5 are associated with this hypocortisolaemic pattern and that some of these alterations change as symptoms improve over the course of treatment. Conclusions Future research priorities include investigations into the role of the HPA axis in day-to-day symptom variation, the time scale in which biological changes in response to treatment occur, and the effects of sex. Furthermore, before conceiving augmentative or alternative treatments that target the described mechanisms, multilevel studies are warranted.

scholarly journals Traumatic stress symptoms and breast cancer: The role of childhood abuse

2010 ◽  
Vol 34 (6) ◽  
pp. 465-470 ◽  
Author(s):  
Rachel E. Goldsmith ◽  
Lina Jandorf ◽  
Heiddis Valdimarsdottir ◽  
Kandace L. Amend ◽  
Brett G. Stoudt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Childhood Abuse ◽  
Traumatic Stress ◽  
Stress Symptoms

Jewish Women's Psychological Well-Being: The Role of Attachment, Separation, and Jewish Identity

2005 ◽  
Vol 29 (2) ◽  
pp. 197-206 ◽  
Author(s):  
Julie L. Goldberg ◽  
Karen M. O'Brien
Keyword(s):  
Jewish Identity ◽  
Psychological Functioning ◽  
Well Being ◽  
Therapeutic Interventions ◽  
Jewish Women ◽  
Late Adolescent ◽  
Psychological Well Being ◽  
Separation From Parents ◽  
Anxiety Depression

The purpose of this study was to examine the contributions of attachment, separation, and Jewish identity to psychological well-being in a sample of 115 late adolescent Jewish women. Results from multiple regression analyses demonstrated that attachment to parents, separation from parents, and Jewish identity collectively accounted for variance in psychological distress, as measured by anxiety, depression, self-esteem problems, and interpersonal problems. Thus, late adolescent Jewish women's psychological functioning may be fostered by therapeutic interventions addressing their relationships with parents and Jewish identity.

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