scholarly journals Impaired mechanism of visual focal attention in posterior cortical atrophy.

2020 ◽  
Vol 34 (7) ◽  
pp. 799-810
Author(s):  
Silvia Primativo ◽  
Sebastian Crutch ◽  
Ivanna Pavisic ◽  
Keir Yong ◽  
Alessia Rossetti ◽  
...  
Keyword(s):  
Cortical Atrophy ◽  
Posterior Cortical Atrophy ◽  
Focal Attention

Very early-onset posterior cortical atrophy

2006 ◽  
Vol 33 (S 1) ◽  
Author(s):  
W.G. Janzarik ◽  
S. Rauer ◽  
C. Weiller ◽  
K. Schmidtke
Keyword(s):  
Early Onset ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy

scholarly journals A-25Clinical Assessment of Posterior Cortical Atrophy

2016 ◽  
Vol 31 (6) ◽  
pp. 592.3-592
Author(s):  
G Wagner ◽  
J Rosen ◽  
G Holguin ◽  
B Frishberg ◽  
A Wang ◽  
...  
Keyword(s):  
Cortical Atrophy ◽  
Posterior Cortical Atrophy

A case with cholinesterase inhibitor responsive asymmetric posterior cortical atrophy

2005 ◽  
Vol 108 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Eunhee Kim ◽  
Yunsoo Lee ◽  
Jongkeol Lee ◽  
Seol-Heui Han
Keyword(s):  
Cholinesterase Inhibitor ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy

P3-265: Olfactory function in posterior cortical atrophy

2012 ◽  
Vol 8 (4S_Part_15) ◽  
pp. P553-P553
Author(s):  
Pirada Witoonpanich ◽  
Rohani Omar ◽  
Natalie Ryan ◽  
Tim Shakespeare ◽  
Keir Yong ◽  
...  
Keyword(s):  
Olfactory Function ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy

Difficulties in diagnosing atypical variants of Alzheimer’s disease

2021 ◽  
Vol 26 (5) ◽  
pp. 16-23
Author(s):  
A. A. Tappakhov ◽  
T. Ya. Nikolaeva ◽  
T. E. Popova ◽  
N. A. Shnayder
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Picture ◽  
Short Term Memory ◽  
Late Onset ◽  
Early Stage ◽  
Primary Progressive Aphasia ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy ◽  
Short Term

Alzheimer’s disease (AD) is the most common cause of dementia in the population. Late onset AD has a classic clinical picture with short-term memory deficit, apraxia and agnosia. Patients with early-onset AD may have an atypical clinical picture which complicates diagnosis. Atypical AD variants include the logopenic variant of primary progressive aphasia, posterior cortical atrophy, behavioral, biparietal, and cortico-basal variants. These variants have pathomorphological signs similar to classical AD, but at an early stage they are characterized by focal atrophy which explains their clinical polymorphism. This article provides a review of the current literature on atypical types of AD and presents a clinical case of a 62-year-old patient in whom the disease debuted with prosopagnosia due to focal atrophy of the temporo-occipital regions of the non-dominant hemisphere.

scholarly journals Latent atrophy factors related to phenotypical variants of posterior cortical atrophy

Neurology ◽  
2020 ◽  
Vol 95 (12) ◽  
pp. e1672-e1685 ◽  
Author(s):  
Colin Groot ◽  
B.T. Thomas Yeo ◽  
Jacob W. Vogel ◽  
Xiuming Zhang ◽  
Nanbo Sun ◽  
...  
Keyword(s):  
Gray Matter ◽  
Visual Processing ◽  
Space Perception ◽  
Object Perception ◽  
Cortical Atrophy ◽  
Intracranial Volume ◽  
Posterior Cortical Atrophy ◽  
Modeling Framework ◽  
Β Amyloid ◽  
The Right

ObjectiveTo determine whether atrophy relates to phenotypical variants of posterior cortical atrophy (PCA) recently proposed in clinical criteria (i.e., dorsal, ventral, dominant-parietal, and caudal) we assessed associations between latent atrophy factors and cognition.MethodsWe employed a data-driven Bayesian modeling framework based on latent Dirichlet allocation to identify latent atrophy factors in a multicenter cohort of 119 individuals with PCA (age 64 ± 7 years, 38% male, Mini-Mental State Examination 21 ± 5, 71% β-amyloid positive, 29% β-amyloid status unknown). The model uses standardized gray matter density images as input (adjusted for age, sex, intracranial volume, MRI scanner field strength, and whole-brain gray matter volume) and provides voxelwise probabilistic maps for a predetermined number of atrophy factors, allowing every individual to express each factor to a degree without a priori classification. Individual factor expressions were correlated to 4 PCA-specific cognitive domains (object perception, space perception, nonvisual/parietal functions, and primary visual processing) using general linear models.ResultsThe model revealed 4 distinct yet partially overlapping atrophy factors: right-dorsal, right-ventral, left-ventral, and limbic. We found that object perception and primary visual processing were associated with atrophy that predominantly reflects the right-ventral factor. Furthermore, space perception was associated with atrophy that predominantly represents the right-dorsal and right-ventral factors. However, individual participant profiles revealed that the large majority expressed multiple atrophy factors and had mixed clinical profiles with impairments across multiple domains, rather than displaying a discrete clinical–radiologic phenotype.ConclusionOur results indicate that specific brain behavior networks are vulnerable in PCA, but most individuals display a constellation of affected brain regions and symptoms, indicating that classification into 4 mutually exclusive variants is unlikely to be clinically useful.

O4-03-06: Effects of cortical visual impairment on navigational ability in posterior cortical atrophy and typical Alzheimer's disease

2015 ◽  
Vol 11 (7S_Part_6) ◽  
pp. P274-P274 ◽  
Author(s):  
Keir X.X. Yong ◽  
Catherine Holloway ◽  
Amelia Carton ◽  
Biao Yang ◽  
Tatsuto Suzuki ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Visual Impairment ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy ◽  
Cortical Visual Impairment

scholarly journals Posterior cortical atrophy: A rare variant of Alzheimer’s disease

2018 ◽  
Vol 10 (2) ◽  
Author(s):  
Michael A. Meyer ◽  
Stephen A. Hudock
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Photon Emission ◽  
Occipital Cortex ◽  
Cortical Atrophy ◽  
Emission Computed Tomography ◽  
Posterior Cortical Atrophy ◽  
Homonymous Hemianopsia

Posterior cortical atrophy is a rare condition first described in 1988 involving progressive degeneration and atrophy of the occipital cortex, often recognized after an unexplained homonymous hemianopsia may be discovered. We report a case in association with Alzheimer’s disease in a 77-year-old female, who underwent brain single-photon emission computed tomography as well brain positron emission tomography using Florbetapir to further evaluate progressive cognitive decline. The patient had also been followed in Ophthalmology for glaucoma, where a progressive unexplained change in her visual field maps were noted over one year consistent with a progressive right homonymous hemianopsia. This rare combination of findings in association with her dementia led to a detailed review of all her imaging studies, concluding with the surprising recognition for a clear hemi-atrophy of the primary left occipital cortex was occurring, consistent with Alzheimer’s disease affecting the primary visual cortex. Further awareness of this disease pattern is needed, as Alzheimer’s disease typically does not affect the primary visual cortex; other conditions to consider in general include Lewy Body dementia, cortico-basal degeneration and prion disease.

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