scholarly journals Alzheimer disease biomarkers, attentional control, and semantic memory retrieval: Synergistic and mediational effects of biomarkers on a sensitive cognitive measure in non-demented older adults.

2015 ◽  
Vol 29 (3) ◽  
pp. 368-381 ◽  
Author(s):  
Andrew J. Aschenbrenner ◽  
David A. Balota ◽  
Chi-Shing Tse ◽  
Anne M. Fagan ◽  
David M. Holtzman ◽  
...  
Keyword(s):  
Older Adults ◽  
Alzheimer Disease ◽  
Semantic Memory ◽  
Attentional Control ◽  
Memory Retrieval ◽  
Disease Biomarkers ◽  
Cognitive Measure

scholarly journals Alzheimer Disease Biomarkers and Driving in Clinically Normal Older Adults

2018 ◽  
Vol 32 (2) ◽  
pp. 101-106 ◽  
Author(s):  
Samantha Allison ◽  
Ganesh M. Babulal ◽  
Sarah H. Stout ◽  
Peggy P. Barco ◽  
David B. Carr ◽  
...  
Keyword(s):  
Older Adults ◽  
Alzheimer Disease ◽  
Disease Biomarkers ◽  
Clinically Normal

scholarly journals Influence of Aging on the Neural Correlates of Autobiographical, Episodic, and Semantic Memory Retrieval

2011 ◽  
Vol 23 (12) ◽  
pp. 4150-4163 ◽  
Author(s):  
Marie St-Laurent ◽  
Hervé Abdi ◽  
Hana Burianová ◽  
Cheryl L. Grady
Keyword(s):  
Older Adults ◽  
Episodic Memory ◽  
Semantic Memory ◽  
Memory Retrieval ◽  
Memory Task ◽  
Neural Correlates ◽  
Partial Least Square ◽  
Least Square ◽  
Younger Adults ◽  
Age Related

We used fMRI to assess the neural correlates of autobiographical, semantic, and episodic memory retrieval in healthy young and older adults. Participants were tested with an event-related paradigm in which retrieval demand was the only factor varying between trials. A spatio-temporal partial least square analysis was conducted to identify the main patterns of activity characterizing the groups across conditions. We identified brain regions activated by all three memory conditions relative to a control condition. This pattern was expressed equally in both age groups and replicated previous findings obtained in a separate group of younger adults. We also identified regions whose activity differentiated among the different memory conditions. These patterns of differentiation were expressed less strongly in the older adults than in the young adults, a finding that was further confirmed by a barycentric discriminant analysis. This analysis showed an age-related dedifferentiation in autobiographical and episodic memory tasks but not in the semantic memory task or the control condition. These findings suggest that the activation of a common memory retrieval network is maintained with age, whereas the specific aspects of brain activity that differ with memory content are more vulnerable and less selectively engaged in older adults. Our results provide a potential neural mechanism for the well-known age differences in episodic/autobiographical memory, and preserved semantic memory, observed when older adults are compared with younger adults.

Attentional Control and Biomarkers for Alzheimer Disease in Non-Demented Older Adults: Sensitivity of a Stroop Switching Test

2012 ◽  
Author(s):  
Jonathan D. Jackson ◽  
David A. Balota ◽  
Janet M. Duchek ◽  
Anne M. Fagan ◽  
David M. Holtzman
Keyword(s):  
Older Adults ◽  
Alzheimer Disease ◽  
Attentional Control

scholarly journals Association of Sleep-Disordered Breathing With Alzheimer Disease Biomarkers in Community-Dwelling Older Adults

2020 ◽  
Vol 77 (6) ◽  
pp. 716 ◽  
Author(s):  
Claire André ◽  
Stéphane Rehel ◽  
Elizabeth Kuhn ◽  
Brigitte Landeau ◽  
Inès Moulinet ◽  
...  
Keyword(s):  
Older Adults ◽  
Alzheimer Disease ◽  
Sleep Disordered Breathing ◽  
Community Dwelling ◽  
Disease Biomarkers ◽  
Community Dwelling Older Adults ◽  
Disordered Breathing

scholarly journals The facilitative effects of glucose ingestion on memory retrieval in younger and older adults: is task difficulty or task domain critical?

2006 ◽  
Vol 95 (2) ◽  
pp. 414-420 ◽  
Author(s):  
Leigh M. Riby ◽  
Hazel McMurtrie ◽  
Jonathan Smallwood ◽  
Carrie Ballantyne ◽  
Andrew Meikle ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Load ◽  
Semantic Memory ◽  
Memory Retrieval ◽  
Repeated Measures ◽  
Task Difficulty ◽  
Enhancement Effect ◽  
Double Blind ◽  
Associate Learning ◽  
Glucose Ingestion

The ingestion of a glucose-containing drink has been shown to improve cognitive performance, particularly memory functioning. However, it remains unclear as to the extent to which task domain and task difficulty moderate the glucose enhancement effect. The aim of this research was to determine whether boosts in performance are restricted to particular classes of memory (episodic v. semantic) or to tasks of considerable cognitive load. A repeated measures (25g glucose v saccharin), counterbalanced, double-blind design was used with younger and older adults. Participants performed a battery of episodic (e.g. paired associate learning) and semantic memory (e.g. category verification) tasks under low and high cognitive load. Electrophysiological measures (heart rate and galvanic skin response) of arousal and mental effort were also gathered. The results indicated that whilst glucose appeared to aid episodic remembering, cognitive load did not exaggerate the facilitative effect. For semantic memory, there was little evidence to suggest that glucose can boost semantic memory retrieval even when the load was manipulated. One exception was that glucose facilitated performance during the difficult category fluency task. Regardless, the present findings are consistent with the domain-specific account in which glucose acts primarily on the hippocampal region, which is known to support episodic memory. The possible contribution of the hippocampus in semantic memory processing is also discussed.

Interindividual Differences in Cognitive Functioning Are Associated with Autobiographical Memory Retrieval Specificity in Older Adults

GeroPsych ◽  
2020 ◽  
Vol 33 (1) ◽  
pp. 15-29 ◽  
Author(s):  
Sarah Peters ◽  
Signy Sheldon
Keyword(s):  
Older Adults ◽  
Cognitive Functioning ◽  
Autobiographical Memory ◽  
Memory Retrieval ◽  
Cognitive Status ◽  
Specific Information ◽  
Generation Task ◽  
Interindividual Differences ◽  
Retrieval Cues ◽  
Contextual Support

Abstract. We examined whether interindividual differences in cognitive functioning among older adults are related to episodic memory engagement during autobiographical memory retrieval. Older adults ( n = 49, 24 males; mean age = 69.93; mean education = 15.45) with different levels of cognitive functioning, estimated using the Montreal Cognitive Assessment (MoCA), retrieved multiple memories (generation task) and the details of a single memory (elaboration task) to cues representing thematic or event-specific autobiographical knowledge. We found that the MoCA score positively predicted the proportion of specific memories for generation and episodic details for elaboration, but only to cues that represented event-specific information. The results demonstrate that individuals with healthy, but not unhealthy, cognitive status can leverage contextual support from retrieval cues to improve autobiographical specificity.

scholarly journals A Novel Touch-Screen, Dual-Language Intervention Program for Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 559-559
Author(s):  
W Quin Yow ◽  
Hui-Ching Chen ◽  
Tharshini Lokanathan ◽  
Attila Achenbach ◽  
Lucienne Blessing
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Semantic Memory ◽  
Cognitive Training ◽  
Dual Language ◽  
Intervention Program ◽  
Verbal Learning ◽  
Verbal Working Memory ◽  
Touch Screen ◽  
Language Intervention

Abstract Although cognitive training in healthy older adults (OA) has been controversial, specific and isolated cognitive skills such as semantic memory can be improved with appropriate designs. Semantic memory has been considered as a clinical marker for cognitive decline in dementia. The current study, as part of a larger touch-screen dual-language intervention program with cognitive training tools, aims to slow down the rate of cognitive decline in OA with dementia (OwD). A set of neuropsychological tests was conducted before and after the training program. After 24 training sessions over 8-12 weeks, OwD (11 females, 1 male, mean=85.8yo) improved significantly in their verbal working memory (Rey Auditory Verbal Learning Test; RAVLT) while performance of the cognitive-healthy OA (5 females, 3 males, mean=76.3yo) remained the same post-intervention. Our findings suggest that touch-screen technology can help OwD improve their semantic memory. The strengths and limitations of our game design and intervention will be discussed. Part of a symposium sponsored by Technology and Aging Interest Group.

scholarly journals Association of CSF Alzheimer's disease biomarkers with postoperative delirium in older adults

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Tamara G. Fong ◽  
Sarinnapha M. Vasunilashorn ◽  
Yun Gou ◽  
Towia A. Libermann ◽  
Simon Dillon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Postoperative Delirium ◽  
Disease Biomarkers
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