Note on gnawing in the gray Norway rat and its coat-character derivative strains.

1946 ◽  
Vol 39 (4) ◽  
pp. 241-242 ◽  
Author(s):  
C. E. Keeler
Keyword(s):  
Norway Rat

scholarly journals Knockdown of Add3 impairs the myogenic response of renal afferent arterioles and middle cerebral arteries

2017 ◽  
Vol 312 (6) ◽  
pp. F971-F981 ◽  
Author(s):  
Fan Fan ◽  
Mallikarjuna R. Pabbidi ◽  
Ying Ge ◽  
Longyang Li ◽  
Shaoxun Wang ◽  
...  
Keyword(s):  
Vascular Reactivity ◽  
Vascular Dysfunction ◽  
Cerebral Arteries ◽  
Chromosome 1 ◽  
Brown Norway ◽  
Myogenic Response ◽  
Norway Rat ◽  
Vasoconstrictor Response ◽  
Brown Norway Rat ◽  
Interfering Rna

We have reported that the myogenic response of the renal afferent arteriole (Af-art) and middle cerebral artery (MCA) and autoregulation of renal and cerebral blood flow are impaired in Fawn-Hooded Hypertensive (FHH) rats. Transfer of a region of chromosome 1 containing γ-adducin (Add3) from the Brown Norway rat rescued the vascular dysfunction and the development of renal disease. To examine whether Add3 is a viable candidate gene altering renal and cerebral hemodynamics in FHH rats, we knocked down the expression of Add3 in rat Af-arts and MCAs cultured for 36-h using a 27-mer Dicer-substrate short interfering RNA (DsiRNA). Control Af-arts constricted by 10 ± 1% in response to an elevation in pressure from 60 to 120 mmHg but dilated by 4 ± 3% when treated with Add3 DsiRNA. Add3 DsiRNA had no effect on the vasoconstrictor response of the Af-art to norepinephrine (10−7 M). Add3 DsiRNA had a similar effect on the attenuation of the myogenic response in the MCA. Peak potassium currents were threefold higher in smooth muscle cells isolated from Af-arts or MCAs transfected with Add3 DsiRNA than in nontransfected cells isolated from the same vessels. This is the first study demonstrating that Add3 plays a role in the regulation of potassium channel function and vascular reactivity. It supports the hypothesis that sequence variants in Add3, which we previously identified in FHH rats, may play a causal role in the impaired myogenic response and autoregulation in the renal and cerebral circulation.

scholarly journals Field trials of flocoumafen against warfarin-resistant infestations of the Norway rat (Rattus norvegicus Berk)

1986 ◽  
Vol 96 (3) ◽  
pp. 467-473 ◽  
Author(s):  
A. P. Buckle
Keyword(s):  
Rattus Norvegicus ◽  
Field Trials ◽  
Anticoagulant Rodenticide ◽  
Complete Control ◽  
Norway Rat ◽  
Norway Rats ◽  
Farm Buildings

SUMMARYThe anticoagulant rodenticide flocoumafen was tested against warfarin-resistant Norway rats (Rattus norvegicus Berk.) infesting farm buildings. Complete control was obtained in 10–21 days (mean 14·2 days) in six treatments in which baits poisoned with 0·005% flocoumafen were maintained, in surplus, until rats ceased to feed from them. A further six treatments, in which the application of poisoned bait was restricted to periodic placements of 50 g, were also completely successful in 15–30 days (mean 21·0 days). Less poisoned bait was used in the restricted flocoumafen treatments than in the unrestricted treatments but the time taken to control the rat infestations was significantly longer.

Norway Rat

1972 ◽  
pp. 365-396
Author(s):  
Roy Robinson
Keyword(s):  
Norway Rat

THE ONSET OF ALLOMETRIC MAMMARY GROWTH IN THE FEMALE HOODED NORWAY RAT

1953 ◽  
Vol 10 (1) ◽  
pp. 35-45 ◽  
Author(s):  
MARIAN SILVER
Keyword(s):  
Growth Rate ◽  
Anterior Pituitary ◽  
Intact Animal ◽  
Mammary Glands ◽  
Mammary Development ◽  
Female Rat ◽  
Suckling Period ◽  
Intact Female ◽  
Norway Rat ◽  
Endogenous Oestrogen

SUMMARY In order to study the factors involved in the initiation of allometric mammary growth, which occurs at about 3 weeks of age in the intact female rat, an attempt to induce this phase prematurely in the suckling gonadectomized animal by means of oestrogen was made. It was found, however, that the mammary glands were practically insensitive to physiological doses of this hormone during the suckling period unless anterior pituitary (a.p.) extract was also given. The relative mammary growth rate in animals treated with a.p. plus oestrogen from the 10th to 27th day of life was similar to that found in control rats receiving oestrogen alone from the 20th to 36th day, but in the former groups allometry was initiated before the 20th day of life. It is suggested that both the level of endogenous oestrogen secretion and the functional activity of the anterior pituitary may be important in determining the time of onset of allometric mammary development in the intact animal.

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