Hunger motivation in goldthioglucose-treated and genetically obese female mice.

1974 ◽  
Vol 86 (5) ◽  
pp. 890-897 ◽  
Author(s):  
Devendra Singh ◽  
John R. Lakey ◽  
Melanie K. Sanders
Keyword(s):  
Female Mice ◽  
Obese Female ◽  
Hunger Motivation

scholarly journals Increased Tumor Growth in Mice with Diet-Induced Obesity: Impact of Ovarian Hormones

Endocrinology ◽  
2006 ◽  
Vol 147 (12) ◽  
pp. 5826-5834 ◽  
Author(s):  
Shoshana Yakar ◽  
Nomeli P. Nunez ◽  
Patricia Pennisi ◽  
Pnina Brodt ◽  
Hui Sun ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Tumor Growth ◽  
Glucose Intolerance ◽  
Tumor Development ◽  
Tumor Growth Rate ◽  
Obese Mice ◽  
Female Mice ◽  
Diet Induced Obesity ◽  
Body Adiposity ◽  
Obese Female

Obesity increases the risk of many cancers in both males and females. This study describes a link between obesity, obesity-associated metabolic alterations, and the risk of developing cancer in male and female mice. The goal of this study was to evaluate the relationship between gender and obesity and to determine the role of estrogen status in obese females and its effect on tumor growth. We examined the susceptibility of C57BL/6 mice to diet-induced obesity, insulin resistance/glucose intolerance, and tumors. Mice were injected sc with one of two tumorigenic cell lines, Lewis lung carcinoma, or mouse colon 38-adenocarcinoma. Results show that tumor growth rate was increased in obese mice vs. control mice irrespective of the tumor cell type. To investigate the effect of estrogen status on tumor development in obese females, we compared metabolic parameters and tumor growth in ovariectomized (ovx) and intact obese female mice. Obese ovx female mice developed insulin resistance and glucose intolerance similar to that observed in obese males. Our results demonstrate that body adiposity increased in ovx females irrespective of the diet administered and that tumor growth correlated positively with body adiposity. Overall, these data point to more rapid tumor growth in obese mice and suggest that endogenous sex steroids, together with diet, affect adiposity, insulin sensitivity, and tumor growth in female mice.

scholarly journals Effects of aerobic exercise training on obese female mice: metabolic and autonomic evaluation

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Michelle Sartori ◽  
Leandro Eziquiel Souza ◽  
Pamella Ramona Souza ◽  
Fernando Santos ◽  
Kátia De Angelis ◽  
...  
Keyword(s):  
Exercise Training ◽  
Aerobic Exercise ◽  
Aerobic Exercise Training ◽  
Female Mice ◽  
Obese Female

Abstract P295: Endothelial Sodium Channel Activation Promotes Cardiac Stiffness in Obese Female Mice

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Javad Habibi ◽  
Annayya R Aroor ◽  
Lixin Ma ◽  
Guanghong Jia ◽  
Adam Whaley-Connell ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Low Dose ◽  
Interstitial Fibrosis ◽  
Diastolic Heart Failure ◽  
The United States ◽  
High Fat ◽  
Female Mice ◽  
Obese Female ◽  
High Fructose ◽  
Endothelial Stiffness

Cardiac diastolic dysfunction (DD) and diastolic heart failure is increasing in concert with obesity and aging population in the United States. In obese and diabetic women, DD is more common than in their male counterparts. This disproportionate increase in DD in obese females may partly explain their loss of sex-related cardiovascular (CV) disease protection. Recent studies have suggested a role for endothelial sodium channel (ENaC) activation in promotion of endothelial stiffness and suppression of flow- (nitric oxide) mediated vasodilation. Moreover, increased mineralocorticoid receptor (MR) activation mediated endothelial stiffness is promoted, in part, by ENaC activation. In this regard, we have recently reported increased plasma aldosterone levels, aortic and cardiac stiffness, and cardiac and vascular MR expression in female mice fed a high fat and high fructose diet (western diet [WD]). This increase in CV stiffness was prevented by very low dose MR antagonism. Accordingly, we hypothesized that inhibition of MR-mediated ENaC activation by using a very low dose of the ENaC inhibitor, amiloride would prevent cardiac stiffening (DD) in WD-fed female mice. Four week old C57BL6/J mice were fed a WD containing high fat (46%), sucrose (17.5%), and high fructose corn syrup (17.5%) with or without a very low dose of amiloride (1mg/kg/day) for 16 weeks. Amiloride significantly attenuated WD-induced impairment of cardiac relaxation in vivo as measured by high resolution magnetic resonance imaging (MRI) as well as cardiac interstitial fibrosis as measured by immunohistochemistry by picrosirius red staining. Moreover, amiloride prevented the development of DD in obese female mice without having effects on blood pressure. These observations support a role for ENaC activation in diet-induced cardiac stiffening (DD) in obese females.

scholarly journals Insulin Receptor Signaling in the GnRH Neuron Plays a Role in the Abnormal GnRH Pulsatility of Obese Female Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119995 ◽  
Author(s):  
Sara A. DiVall ◽  
Danny Herrera ◽  
Bonnie Sklar ◽  
Sheng Wu ◽  
Fredric Wondisford ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Receptor Signaling ◽  
Gnrh Neuron ◽  
Female Mice ◽  
Obese Female ◽  
Insulin Receptor Signaling

scholarly journals Acute lung injury induced by intestinal ischemia and reperfusion is altered in obese female mice

2018 ◽  
Author(s):  
Yanira Riffo-Vasquez ◽  
Evelyn Fantozzi ◽  
Sara Rodrigues-Garbin ◽  
Fernanda Ricardo-Da Silva ◽  
Ricardo Oliveira-Filho ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Intestinal Ischemia ◽  
Ischemia And Reperfusion ◽  
Female Mice ◽  
Obese Female

scholarly journals Positive Effects of Diphlorethohydroxycarmalol (DPHC) on the Stability of the Integument Structure in Diet-Induced Obese Female Mice

2015 ◽  
Vol 19 (3) ◽  
pp. 145-152 ◽  
Author(s):  
Chae-lim Kim ◽  
Sun-yeong Cha ◽  
Min Young Chun ◽  
Bumsoo Kim ◽  
Min Young Choi ◽  
...  
Keyword(s):  
Female Mice ◽  
Positive Effects ◽  
Obese Female ◽  
The Stability

Prefrontal cortex inflammation and liver pathologies accompany cognitive and motor deficits following Western diet consumption in non-obese female mice

Life Sciences ◽  
2020 ◽  
Vol 241 ◽  
pp. 117163 ◽  
Author(s):  
Ekaterina Veniaminova ◽  
Margarita Oplatchikova ◽  
Lucien Bettendorff ◽  
Elena Kotenkova ◽  
Alexander Lysko ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Western Diet ◽  
Motor Deficits ◽  
Female Mice ◽  
Obese Female
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