Effects of bilateral lesions of the frontal granular cortex on the social behavior of rhesus monkeys.

1970 ◽  
Vol 72 (3) ◽  
pp. 452-461 ◽  
Author(s):  
Allyn C. Deets ◽  
Harry F. Harlow ◽  
Sheo D. Singh ◽  
Allen J. Blomquist
Keyword(s):  
Social Behavior ◽  
Rhesus Monkeys ◽  
The Social ◽  
Bilateral Lesions

Effects of opioid receptor blockade on the social behavior of rhesus monkeys living in large family groups

1995 ◽  
Vol 28 (2) ◽  
pp. 71-84 ◽  
Author(s):  
Frances L. Martel ◽  
Claire M. Nevison ◽  
Michael J. A. Simpson ◽  
Eric B. Keverne
Keyword(s):  
Social Behavior ◽  
Opioid Receptor ◽  
Rhesus Monkeys ◽  
Large Family ◽  
Receptor Blockade ◽  
The Social ◽  
Family Groups

Drinking and the Social Behavior of Rhesus Monkeys

1971 ◽  
Vol 32 (3) ◽  
pp. 764-774 ◽  
Author(s):  
Reginald J. Cressman ◽  
Theodore E. Cadell
Keyword(s):  
Social Behavior ◽  
Rhesus Monkeys ◽  
The Social

A stranger in the family? On the social behavior of a leucistic collared peccary (Pecari tajacu) with pigmented conspecifics

2019 ◽  
Vol 60 (2) ◽  
pp. 303-305
Author(s):  
Valdir Leite da Silva ◽  
José Cândido ◽  
José Nelson Campanha ◽  
Doraci R. de Oliveira ◽  
Carla Gheler-Costa ◽  
...  
Keyword(s):  
Social Behavior ◽  
The Social ◽  
The Family ◽  
Pecari Tajacu ◽  
Collared Peccary

scholarly journals Pharmacological modulation of AMPA receptors rescues specific impairments in social behavior associated with the A350V Iqsec2 mutation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Renad Jabarin ◽  
Nina Levy ◽  
Yasmin Abergel ◽  
Joshua H. Berman ◽  
Amir Zag ◽  
...  
Keyword(s):  
Social Behavior ◽  
Ampa Receptors ◽  
Emotional State ◽  
Social Discrimination ◽  
Glutamatergic Synapses ◽  
Behavioral Deficits ◽  
Pharmacological Modulation ◽  
The Social ◽  
State Preference ◽  
Molecular Pathophysiology

AbstractIn this study we tested the hypothesis that pharmacological modulation of glutamatergic neurotransmission could rescue behavioral deficits exhibited by mice carrying a specific mutation in the Iqsec2 gene. The IQSEC2 protein plays a key role in glutamatergic synapses and mutations in the IQSEC2 gene are a frequent cause of neurodevelopmental disorders. We have recently reported on the molecular pathophysiology of one such mutation A350V and demonstrated that this mutation downregulates AMPA type glutamatergic receptors (AMPAR) in A350V mice. Here we sought to identify behavioral deficits in A350V mice and hypothesized that we could rescue these deficits by PF-4778574, a positive AMPAR modulator. Using a battery of social behavioral tasks, we found that A350V Iqsec2 mice exhibit specific deficits in sex preference and emotional state preference behaviors as well as in vocalizations when encountering a female mouse. The social discrimination deficits, but not the impaired vocalization, were rescued with a single dose of PF-4778574. We conclude that social behavior deficits associated with the A350V Iqsec2 mutation may be rescued by enhancing AMPAR mediated synaptic transmission.

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