Anticipatory general activity in thirsty rats.

1968 ◽  
Vol 65 (3, Pt.1) ◽  
pp. 511-513 ◽  
Author(s):  
Robert C. Bolles
Keyword(s):  
General Activity

Cloud Computing in Library

2014 ◽  
Vol 3 ◽  
pp. 94-112
Author(s):  
Angelė Pečeliūnaitė
Keyword(s):  
Cloud Computing ◽  
Scientific Community ◽  
Digital Age ◽  
International Experience ◽  
The Internet ◽  
Library Services ◽  
General Activity ◽  
Computing Services ◽  
Cloud Computing Services

The article analyses the possibility of how Cloud Computing can be used by libraries to organise activities online. In order to achieve a uniform understanding of the essence of technology SaaS, IaaS, and PaaS, the article discusses the Cloud Computing services, which can be used for the relocation of libraries to the Internet. The improvement of the general activity of libraries in the digital age, the analysis of the international experience in the libraries are examples. Also the article discusses the results of a survey of the Lithuanian scientific community that confirms that 90% of the scientific community is in the interest of getting full access to e-publications online. It is concluded that the decrease in funding for libraries, Cloud Computing can be an economically beneficial step, expanding the library services and improving their quality.

Effect of Morphine Sulfate on Spontaneous Activity Level of the Albino Rat

1965 ◽  
Vol 16 (3) ◽  
pp. 693-696 ◽  
Author(s):  
L. Glenn Collins
Keyword(s):  
Drug Effect ◽  
Activity Wheel ◽  
Activity Level ◽  
Morphine Sulfate ◽  
Albino Rats ◽  
Systematic Effect ◽  
General Activity ◽  
Albino Rat ◽  
General Activity Level ◽  
Hunger Drive

In two experiments involving 40 albino rats and two dosage levels of morphine sulfate it was found that relatively high analgesic dosages of morphine significantly depressed general activity level in the revolving drum. Also, there was a significant interaction between drug effect and hunger drive. In the case of moderate analgesic doses (7 mg/kg) no systematic effect of morphine on activity-wheel performance was noted.

Organization of rat circadian rhythms during daily infusion of melatonin or S20098, a melatonin agonist

1999 ◽  
Vol 277 (3) ◽  
pp. R812-R828 ◽  
Author(s):  
B. Pitrosky ◽  
R. Kirsch ◽  
A. Malan ◽  
E. Mocaer ◽  
P. Pevet
Keyword(s):  
Body Temperature ◽  
Circadian Rhythms ◽  
Phase Response Curve ◽  
Constant Darkness ◽  
Time Interval ◽  
General Activity ◽  
Activity Peak ◽  
Free Running ◽  
Wheel Activity ◽  
Free Running Period

Daily administration of melatonin or S20098, a melatonin agonist, is known to entrain the free-running circadian rhythms of rats. The effects of the duration of administration on entrainment were studied. The animals demonstrated free-running circadian rhythms (running-wheel activity, body temperature, general activity) in constant darkness. Daily infusions of melatonin or S20098 for 1, 8, or 16 h entrained the circadian rhythms to 24 h. Two daily infusions of 1 h (separated by 8 h) entrained the activity peak within the shorter time interval. The entraining properties of melatonin and S20098 were similar and were affected neither by pinealectomy nor by infusion of 1- or 8-h duration. However, with 16-h infusion, less than half of the animals became entrained. Once entrained, the phase angle between the onset of infusion and the rhythms (onset of activity or acrophase of body temperature) increased with the duration of infusion. Before entrainment, the free-running period increased with the duration of infusion, an effect that was not predictable from the phase response curve.

scholarly journals Activity-relevant similarity values for fingerprints and implications for similarity searching

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 591 ◽  
Author(s):  
Swarit Jasial ◽  
Ye Hu ◽  
Martin Vogt ◽  
Jürgen Bajorath
Keyword(s):  
Characteristic Feature ◽  
Success Rate ◽  
Similarity Search ◽  
Unsolved Problem ◽  
Biological Activities ◽  
Similarity Searching ◽  
Search Performance ◽  
General Activity ◽  
Active Compounds ◽  
Scientific Foundation

A largely unsolved problem in chemoinformatics is the issue of how calculated compound similarity relates to activity similarity, which is central to many applications. In general, activity relationships are predicted from calculated similarity values. However, there is no solid scientific foundation to bridge between calculated molecular and observed activity similarity. Accordingly, the success rate of identifying new active compounds by similarity searching is limited. Although various attempts have been made to establish relationships between calculated fingerprint similarity values and biological activities, none of these has yielded generally applicable rules for similarity searching. In this study, we have addressed the question of molecular versus activity similarity in a more fundamental way. First, we have evaluated if activity-relevant similarity value ranges could in principle be identified for standard fingerprints and distinguished from similarity resulting from random compound comparisons. Then, we have analyzed if activity-relevant similarity values could be used to guide typical similarity search calculations aiming to identify active compounds in databases. It was found that activity-relevant similarity values can be identified as a characteristic feature of fingerprints. However, it was also shown that such values cannot be reliably used as thresholds for practical similarity search calculations. In addition, the analysis presented herein helped to rationalize differences in fingerprint search performance.

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