Effects of hippocampal lesions and posttrial strychnine administration on maze behavior in the rat.

1966 ◽  
Vol 62 (2) ◽  
pp. 243-249 ◽  
Author(s):  
Donald G. Stein ◽  
Daniel P. Kimble
Keyword(s):  
Hippocampal Lesions

Effects of CS preexposures on avoidance learning in rats with hippocampal lesions.

1969 ◽  
Vol 69 (4, Pt.1) ◽  
pp. 739-747 ◽  
Author(s):  
James E. Ackil ◽  
Roger L. Mellgren ◽  
Carl Halgren ◽  
Gabriel P. Frommer
Keyword(s):  
Avoidance Learning ◽  
Hippocampal Lesions

scholarly journals In Vivo Measurement of Neurochemical Abnormalities in the Hippocampus in a Rat Model of Cuprizone-Induced Demyelination

Diagnostics ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 45
Author(s):  
Do-Wan Lee ◽  
Jae-Im Kwon ◽  
Chul-Woong Woo ◽  
Hwon Heo ◽  
Kyung Won Kim ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Rat Model ◽  
Resonance Spectroscopy ◽  
Chow Diet ◽  
Gamma Aminobutyric Acid ◽  
Sprague Dawley ◽  
In Vivo Measurement ◽  
Hippocampal Lesions ◽  
Total Creatine

This study quantitatively measured the changes in metabolites in the hippocampal lesions of a rat model of cuprizone-induced demyelination as detected using in vivo 7 T proton magnetic resonance spectroscopy. Nineteen Sprague Dawley rats were randomly divided into two groups and fed a normal chow diet or cuprizone (0.2%, w/w) for 7 weeks. Demyelinated hippocampal lesions were quantitatively measured using a 7 T magnetic resonance imaging scanner. All proton spectra were quantified for metabolite concentrations and relative ratios. Compared to those in the controls, the cuprizone-induced rats had significantly higher concentrations of glutamate (p = 0.001), gamma-aminobutyric acid (p = 0.019), and glutamate + glutamine (p = 0.001); however, creatine + phosphocreatine (p = 0.006) and myo-inositol (p = 0.001) concentrations were lower. In addition, we found that the glutamine and glutamate complex/total creatine (p < 0.001), glutamate/total creatine (p < 0.001), and GABA/total creatine (p = 0.002) ratios were significantly higher in cuprizone-treated rats than in control rats. Our results showed that cuprizone-induced neuronal demyelination may influence the severe abnormal metabolism in hippocampal lesions, and these responses could be caused by microglial activation, mitochondrial dysfunction, and astrocytic necrosis.

Selective bilateral hippocampal lesions after theophylline-induced status epilepticus causes a permanent amnesic syndrome

2011 ◽  
Vol 18 (7) ◽  
pp. 964-966 ◽  
Author(s):  
Z. Kohl ◽  
G. Uyanik ◽  
R. Lürding ◽  
G. Schuierer ◽  
U. Bogdahn ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Amnesic Syndrome ◽  
Hippocampal Lesions

Prefrontal dopamine release and sensory-specific satiety altered in rats with neonatal ventral hippocampal lesions

2012 ◽  
Vol 231 (1) ◽  
pp. 97-104 ◽  
Author(s):  
Carlos Eduardo Macedo ◽  
Marie-Josée Angst ◽  
Serge Gobaille ◽  
Carmen Schleef ◽  
Blandine Guignard ◽  
...  
Keyword(s):  
Dopamine Release ◽  
Hippocampal Lesions
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