Random or Fixed? An Empirical Examination of Meta-Analysis Model Choices

2018 ◽  
Vol 22 (3) ◽  
pp. 290-304 ◽  
Author(s):  
Kathleen L. Slaney ◽  
Donna Tafreshi ◽  
Richard Hohn

When conducting meta-analyses, researchers must make decisions about which statistical model is most appropriate for the specific context and aims of the meta-analysis. Although there are several meta-analysis models, most researchers choose between two general models: fixed-effect (FE) and random-effects (RE). Yet, the basis on which these two general models are distinguished and of when it is appropriate to use one or the other varies in the methodological literature. Although model-to-inference inconsistencies have been previously noted, there has been little empirical investigation of whether, and to what extent, the varying conceptualizations of the distinctions between FE and RE models are reflected in published meta-analyses. The present study explores whether conceptualizations of model distinctions among psychological researchers are consistent with those in the methods literature. We also examine model choices and rationales given by psychological researchers in two samples of published meta-analyses in psychology-related journals. We identify four primary categories for distinguishing between FE and RE models, only two of which were predominant in our samples. Although model choice appears to be reported at a moderately high rate, many researchers continue not to provide explicit rationales for their model choices or do not clearly tie model choices to the specific research aims of the meta-analyses. Implications of these findings are discussed.

2010 ◽  
Vol 58 (3) ◽  
pp. 257-278 ◽  
Author(s):  
Ashley Anker ◽  
Amber Marie Reinhart ◽  
Thomas Hugh Feeley

2016 ◽  
Vol 13 (1) ◽  
pp. 713 ◽  
Author(s):  
Gülşah Başol ◽  
Mehmet Fatih Doguyurt ◽  
Seda Demir

<p>This content analysis study aims to methodologically evaluate the appropriateness of meta-analyses, conducted on Turkish samples on a variety of topics. Through an exhausting literature review, 80 meta-analyses were gathered together and coded into a detailed Meta-Analysis Evaluation Form.  The form consisted of 59 items (1 = Not Present, 2 = Present and 3 = Not Mentioned) both regarding the study and substantial characteristics. Two researchers coded the studies and the reliability of the coding of five studies indicated no problems with consistencies of the codings (Kappa= .90). According to the results, the most often encountered problem in meta-analyses was reporting both the fixed and random effects analyses without making a priori decision about the model choice. It was found that 60.0% of the meta-analyses investigated by the current study excluded studies conducted abroad which resulted underrepresentation of the literature.  Furthermore, the studies suffered from a small sample size issues. The methodology (how the studies were selected, coding form, reliability of the codings and etc.) was not explained clearly in more than a quarter of the studies. Therefore, it would be hard to claim that they have sufficient level of internal and external validity. It was hoped that researchers may benefit from the results of the current study to conduct better quality meta-analysis in the future.</p><p> </p><p><strong>Özet</strong></p><p>Bu içerik analizi çalışmasının amacı Türkiye'de yapılan meta analiz çalışmalarının metodolojik değerlendirmesinin yapılmasıdır. Meta Analiz Değerlendirme Formu üzerinden Türkiye literatüründeki 80 meta analiz çalışması kodlanmıştır. Değerlendirme formu çalışmaların künyelerini ve meta analiz yönteminin kullanımındaki çeşitlenmeyi içeren 59 (Evet-Hayır-Belirtilmemiş şeklinde cevaplanabilecek) maddeyi kapsamaktadır. İki araştırmacı kodlamaları gerçekleştirmiş ve öncesinde beş çalışmalık bir pilot çalışma üzerinden kodlamaları arasındaki uyum hesaplanmış ve Kappa katsayısı (Kappa= .90) yeterli düzeyde bulunmuştur. Sonuçlara göre meta analiz çalışmalarındaki en belirgin problem herhangi bir tercihte bulunmaksızın sabit ve rasgele etkiler modellerinin birlikte rapor edilmesidir. Çalışmaların %60'ında yurtdışı çalışmalar dahil edilmeksizin Türkiye örneklemindeki çalışmaları kullanarak meta analiz yapılmıştır. Yurtdışı çalışmalara yer veren meta analizlerde ise sayının çok düşük olduğu dolayısıyla örneklemin temsil ediciliğinin düşük olduğu görülmüştür. Meta analizlerde örneklem büyüklüğünün sayıca çok yetersiz olduğu ya da olmadığı görülmüştür. Çalışmaların dörtte birinden fazlasında metodoloji bölümünde çalışmaların nasıl toplandığı, kodlama formu, kodlamaların güvenirliği gibi konular açıklanmamıştır. Bu durum ilgili meta analiz çalışmalarının güvenirlik ve geçerliğini düşürmektedir. Mevcut değerlendirme çalışmasının, gelecekte meta analiz konusunda çalışacak araştırmacılara metodolojik bakımdan daha kaliteli araştırmalar ortaya koymaları hususunda katkı sağlayacağı beklenmektedir.</p>


2014 ◽  
Vol 17 (2) ◽  
pp. 64-64 ◽  
Author(s):  
Adriani Nikolakopoulou ◽  
Dimitris Mavridis ◽  
Georgia Salanti

RMD Open ◽  
2020 ◽  
Vol 6 (1) ◽  
pp. e001030 ◽  
Author(s):  
Andrew Khor ◽  
Cheryl-Ann Ma ◽  
Cassandra Hong ◽  
Laura Li-Yao Hui ◽  
Ying Ying Leung

BackgroundAssociation between diabetes mellitus (DM) and risk of osteoarthritis (OA) can be confounded by body mass index (BMI), a strong risk factor for both conditions. We evaluate the association between DM or hyperglycaemia with OA using systematic review and meta-analysis.MethodsWe searched PubMed and Web of Science databases in English for studies that gave information on the association between DM and OA. Two meta-analysis models were conducted to address: (1) risk of DM comparing subjects with and without OA and (2) risk of OA comparing subjects with and without DM. As far as available, risk estimates that adjusted for BMI were used.Results31 studies with a pooled population size of 295 100 subjects were reviewed. 16 and 15 studies reported positive associations and null/ negative associations between DM and OA. 68.8% of positive studies had adjusted for BMI, compared with 93.3% of null/negative studies. In meta-analysis model 1, there was an increase prevalence of DM in subjects with OA compared with those without (OR 1.56, 95% CI 1.28 to 1.89). In meta-analysis model 2, there was no increased risk of OA (OR 1.14, 95% CI 0.98 to 1.33) in subjects with DM compared with those without, regardless of gender and OA sites. Comparing subjects with DM to those without, an increased risk of OA was noted in cross-sectional studies, but not in case-control and prospective cohort studies.ConclusionsThis meta-analysis does not support DM as an independent risk factor for OA. BMI was probably the most important confounding factor.


2020 ◽  
Vol 7 (8) ◽  
pp. 192151 ◽  
Author(s):  
Farzana Jahan ◽  
Earl W. Duncan ◽  
Susanna M. Cramb ◽  
Peter D. Baade ◽  
Kerrie L. Mengersen

Analysis of spatial patterns of disease is a significant field of research. However, access to unit-level disease data can be difficult for privacy and other reasons. As a consequence, estimates of interest are often published at the small area level as disease maps. This motivates the development of methods for analysis of these ecological estimates directly. Such analyses can widen the scope of research by drawing more insights from published disease maps or atlases. The present study proposes a hierarchical Bayesian meta-analysis model that analyses the point and interval estimates from an online atlas. The proposed model is illustrated by modelling the published cancer incidence estimates available as part of the online Australian Cancer Atlas (ACA). The proposed model aims to reveal patterns of cancer incidence for the 20 cancers included in ACA in major cities, regional and remote areas. The model results are validated using the observed areal data created from unit-level data on cancer incidence in each of 2148 small areas. It is found that the meta-analysis models can generate similar patterns of cancer incidence based on urban/rural status of small areas compared with those already known or revealed by the analysis of observed data. The proposed approach can be generalized to other online disease maps and atlases.


2020 ◽  
Author(s):  
Farzana Jahan ◽  
Earl W Duncan ◽  
Susanna M Cramb ◽  
Peter D Baade ◽  
Kerrie Lee Mengersen

Abstract Background: Cancer atlases often provide estimates of cancer incidence, mortality or survival across small areas of a region or country. A recent example of a cancer atlas is the Australian cancer atlas (ACA), that provides interactive maps to visualise spatially smoothed estimates of cancer incidence and survival for 20 different cancers over 2148 small areas across Australia. Methods: The present study proposes a multivariate Bayesian meta-analysis model, which can model multiple cancers jointly using summary measures without requiring access to the unit record data. This new approach is illustrated by modelling the publicly available spatially smoothed standard incidence ratios (SIR) for multiple cancers in the ACA divided into three groups: common, rare/less common and smoking-related. The multivariate Bayesian meta-analysis models are fitted to each group in order to explore any possible association between the cancers in three remoteness regions: major cities, regional and remote areas across Australia. Results: Substantive correlation was observed among some cancer types. There was evidence that the magnitude of this correlation varied according to remoteness of a region. High risk areas for specific combinations of cancer types were identified and visualised from the proposed model. Conclusions: Publicly available spatially smoothed disease estimates can be used to explore additional research questions by modelling multiple cancer types jointly. These proposed multivariate meta-analysis models could be useful when unit record data are unavailable because of privacy and confidentiality requirements.


2021 ◽  
Author(s):  
David Margraf ◽  
Sarah J Brown ◽  
Heather L Blue ◽  
Tamara L Bezdicek ◽  
Julian Wolfson ◽  
...  

Abstract Background: Patients requiring emergent warfarin reversal (EWR) have been prescribed three-factor prothrombin complex concentrate (PCC3) and four-factor prothrombin complex concentrate (PCC4) to reverse the anticoagulant effects of warfarin. There is no existing systematic review and meta-analysis of studies directly comparing PCC3 and PCC4. Methods: The primary objective of this systematic review and meta-analysis was to determine the effectiveness of achieving study defined target INR goal after PCC3 or PCC4 administration. Secondary objectives were to determine the difference in safety endpoints, thromboembolic events (TE), and survival during the patients’ hospital stay. Random-effects meta-analysis models were used to estimate the odds ratios (OR), and heterogeneity associated with the outcomes. The Newcastle-Ottawa Scale was used to assess study quality, and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Results: Ten full-text manuscripts and 5 abstracts provided data for the primary and secondary outcomes. Patients requiring emergent warfarin reversal had more than three times the odds of reversal to goal INR when they were given PCC4 compared to PCC3 (OR = 3.61, 95% CI: 1.97-6.60, p < 0.001). There was no meaningful clinical association or statistically significant result between PCC4 and PCC3 groups in TE (OR = 1.56, 95% CI: 0.83-2.91, p = 0.17), or survival during hospital stay (OR = 1.34, 95% CI: 0.81-2.23, p = 0.25). Conclusion: PCC4 is more effective than PCC3 in meeting specific predefined INR goals, and has similar safety profiles in patients requiring emergent reversal of the anticoagulant effects of warfarin.


2019 ◽  
Vol 41 ◽  
pp. e2019013 ◽  
Author(s):  
Sung Ryul Shim ◽  
Seong-Jang Kim ◽  
Jonghoo Lee ◽  
Gerta Rücker

The objective of this study is to describe the general approaches to network meta-analysis that are available for quantitative data synthesis using R software. We conducted a network meta-analysis using two approaches: Bayesian and frequentist methods. The corresponding R packages were “gemtc” for the Bayesian approach and “netmeta” for the frequentist approach. In estimating a network meta-analysis model using a Bayesian framework, the “rjags” package is a common tool. “rjags” implements Markov chain Monte Carlo simulation with a graphical output. The estimated overall effect sizes, test for heterogeneity, moderator effects, and publication bias were reported using R software. The authors focus on two flexible models, Bayesian and frequentist, to determine overall effect sizes in network meta-analysis. This study focused on the practical methods of network meta-analysis rather than theoretical concepts, making the material easy to understand for Korean researchers who did not major in statistics. The authors hope that this study will help many Korean researchers to perform network meta-analyses and conduct related research more easily with R software.


2018 ◽  
Author(s):  
Nhan Thi Ho ◽  
Fan Li

ABSTRACTBackgroundThe rapid growth of high-throughput sequencing-based microbiome profiling has yielded tremendous insights into human health and physiology. Data generated from high-throughput sequencing of 16S rRNA gene amplicons are often preprocessed into composition or relative abundance. However, reproducibility has been lacking due to the myriad of different experimental and computational approaches taken in these studies. Microbiome studies may report varying results on the same topic, therefore, meta-analyses examining different microbiome studies to provide robust results are important. So far, there is still a lack of implemented methods to properly examine differential relative abundances of microbial taxonomies and to perform meta-analysis examining the heterogeneity and overall effects across microbiome studies.ResultsWe developed an R package ‘metamicrobiomeR’ that applies Generalized Additive Models for Location, Scale and Shape (GAMLSS) with a zero-inflated beta (BEZI) family (GAMLSS-BEZI) for analysis of microbiome relative abundance datasets. Both simulation studies and application to real microbiome data demonstrate that GAMLSS-BEZI well performs in testing differential relative abundances of microbial taxonomies. Importantly, the estimates from GAMLSS-BEZI are log(odds ratio) of relative abundances between groups and thus are comparable between microbiome studies. As such, we also apply random effects meta-analysis models to pool estimates and their standard errors across microbiome studies. We demonstrate the meta-analysis workflow and highlight the utility of our package on four studies comparing gut microbiomes between male and female infants in the first six months of life.ConclusionsGAMLSS-BEZI allows proper examination of microbiome relative abundance data. Random effects meta-analysis models can be directly applied to pool comparable estimates and their standard errors to evaluate the heterogeneity and overall effects across microbiome studies. The examples and workflow using our metamicrobiomeR package are reproducible and applicable for the analyses and meta-analyses of other microbiome studies.


2020 ◽  
Vol 19 (7) ◽  
pp. 646-652
Author(s):  
Todd Ruppar

The number of systematic reviews and meta-analyses submitted to nursing and allied health journals continues to grow. Well-conducted and reported syntheses of research are valuable to advancing science. One of the common critiques identified in these manuscripts involves how the authors addressed heterogeneity among the studies in their meta-analyses. Methodologically inappropriate approaches regarding heterogeneity introduce error and bias into analyses and may lead to incorrect findings and conclusions. This article will discuss some of the approaches to take as well as avoid when addressing heterogeneity in meta-analyses, including suggestions for how to choose a fixed-effect or random-effects meta-analysis model and steps to follow to address heterogeneity in meta-analysis results.


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