Principles of Drug Addiction Treatment: A Research-Based Guide: Third Edition

2012 ◽  
Keyword(s):  
Drug Addiction ◽  
Addiction Treatment ◽  
Drug Addiction Treatment

scholarly journals The Role of Personal, Famililal and Social Awarenesss in Permanent Drug Abandonment in Kashan Drug Addiction Treatment Centers

2019 ◽  
Vol 21 (4) ◽  
pp. 330-343
Author(s):  
SS Hoseinizadeh ◽  
M Niazi ◽  
M Mehtari Arani ◽  
◽  
◽  
...  
Keyword(s):  
Drug Addiction ◽  
Addiction Treatment ◽  
Drug Addiction Treatment

scholarly journals Growth Hormone Secretagogue Receptor 1A Antagonist JMV2959 Effectively Prevents Morphine Memory Reconsolidation and Relapse

2021 ◽  
Vol 12 ◽  
Author(s):  
Jing Zhao ◽  
Xinyu Du ◽  
Mingzhu Chen ◽  
Shimin Zhu
Keyword(s):  
Growth Hormone ◽  
Drug Addiction ◽  
Addiction Treatment ◽  
Memory Reconsolidation ◽  
Potential Candidate ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue ◽  
Drug Seeking ◽  
Food And Water Intake ◽  
Drug Addiction Treatment

Relapse to drug seeking after prolonged abstinence is a major problem in the clinical treatment of drug addiction. The use of pharmacological interventions to disrupt established drug reward memories is a promising strategy for the treatment of drug addiction. A growth hormone secretagogue receptor 1 A antagonist, JMV2959, has been shown to reduce morphine-induced conditioned place preference (CPP) in rats within hours of intervention; thus, JMV2959 is a potential candidate for drug addiction treatment. However, the effect of JMV2959 on reconsolidation to disrupt drug seeking remains unknown. In this study, we assessed the effect of JMV2959 on morphine induced memory reconsolidation to inhibit drug seeking after drug withdrawal. Our results showed that the administration of JMV2959 (6 mg/kg) significantly reduced environmental cue induced CPP, which suggested a preventive effect of JMV2959 on morphine induced memory reconsolidation. Additionally, JMV2959 administration significantly altered the locomotor activity and food and water intake but did not significantly alter the natural reward preference. We concluded that JMV2959 may be an effective candidate to treat drug addiction.

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