Prolonged exposure and beyond: Setting an ethical research agenda for new treatments and the adaptation and enhancement of evidence based psychotherapies for PTSD

In this first edition book, editors Jolly and Jarvis have compiled a range of important, contemporary gifted education topics. Key areas of concern focus on evidence-based practices and research findings from Australia and New Zealand. Other contributors include 14 gifted education experts from leading Australian and New Zealand Universities and organisations. Exploring Gifted Education: Australian and New Zealand Perspectives, introduced by the editors, is well organised. Jolly and Jarvis’s central thesis in their introduction is to acknowledge the disparity between policy, funding and practice in Australia and New Zealand. Specifically, in relation to Australia, they note that a coordinated, national research agenda is absent, despite recommendations published by the Australian Senate Inquiry almost 20 years ago.

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Updates on NORA Musculoskeletal Health Cross-Sector Council Activities

Proceedings of the Human Factors and Ergonomics Society Annual Meeting ◽

10.1177/1071181320641304 ◽

2020 ◽

Vol 64 (1) ◽

pp. 1279-1281

Author(s):

David M. Rempel ◽

Scott Schneider ◽

Sean Gallagher ◽

Sheree Gibson ◽

Susan Kotowski ◽

...

Keyword(s):

Musculoskeletal Disorders ◽

Research Agenda ◽

Occupational Safety ◽

Occupational Safety And Health ◽

Evidence Based ◽

Musculoskeletal Health ◽

Work Related ◽

Safety And Health ◽

Work Related Musculoskeletal Disorders ◽

Collaborative Efforts

The National Occupational Research Agenda (NORA) is a research framework for the nation and for the National Institute for Occupational Safety and Health (NIOSH). The NORA Musculoskeletal Health Cross-Sector (MUS) Council focuses on the mitigation of work-related musculoskeletal disorders (WMSDs). Two projects have been chosen by the MUS Council for disseminating existing information on ergonomic assessment methods and interventions. The first project involves collaboration with the AIHA Ergonomics Committee on the latest update of the AIHA Ergonomic Assessment Toolkit. The second project aims to post all-industry information on ergonomic solutions/interventions/guidelines in collaboration with the International Ergonomics Association (IEA). The MUS Council plans on leveraging the collaborative efforts for promoting widespread adoption of evidence-based workplace practices for the prevention of WMSDs.

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Establishing a Research Agenda on Mobile Health Technologies and Later-Life Pain Using an Evidence-Based Consensus Workshop Approach

Journal of Pain ◽

10.1016/j.jpain.2018.06.006 ◽

2018 ◽

Vol 19 (12) ◽

pp. 1416-1423 ◽

Cited By ~ 3

Author(s):

Elaine Wethington ◽

Christopher Eccleston ◽

Geri Gay ◽

Rachael Gooberman-Hill ◽

Patricia Schofield ◽

...

Keyword(s):

Mobile Health ◽

Research Agenda ◽

Later Life ◽

Evidence Based ◽

Health Technologies

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The future of clinical trials

Oxford Textbook of Medicine ◽

10.1093/med/9780199204854.003.020304 ◽

2010 ◽

pp. 45-47

Author(s):

Perry Nisen ◽

Patrick Vallance

Keyword(s):

Clinical Trial ◽

Clinical Trials ◽

Alternative Medicine ◽

20Th Century ◽

Evidence Based Medicine ◽

Evidence Based ◽

Scientific Evaluation ◽

New Treatments ◽

Based Medicine ◽

Short Section

Clinical trials are the bedrock of evidence-based medicine. Introduced in the mid 20th century, they heralded a move away from opinion and anecdote to a more scientific evaluation of new treatments. Indeed, it could be argued that it is the clinical trial and the application of scientific method to determine which treatments work that distinguishes ‘medicine’ from ‘alternative medicine’. The aim of this short section is to outline the way in which clinical trials are likely to evolve over the next few years....

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The Partially Clothed Emperor: Evidence-Based Practices

Journal of Contemporary Criminal Justice ◽

10.1177/1043986217750444 ◽

2018 ◽

Vol 34 (1) ◽

pp. 97-114 ◽

Cited By ~ 3

Author(s):

Faye S. Taxman

Keyword(s):

Work Environment ◽

Research Agenda ◽

Assessment Tool ◽

Empirical Studies ◽

Evidence Based ◽

Change Strategies ◽

Evidence Based Practices ◽

Core Set ◽

Criminogenic Needs ◽

Operational Issues

The evidence-based practices literature has defined a core set of practices and treatments that are effective, at least in empirical studies. Implementing these evidence-based practices and treatments requires a different set of empirical studies to understand the operational issues that affects client-driven outcomes. In this article, we review the following three areas: (a) use of a standardized risk and need assessment tool, (b) use of cognitive-behavioral programs to address criminogenic needs, and (c) use of swift and certain responses to shape behavior. The review focuses on the unanswered questions regarding implementation and organizational change strategies to increase receptivity for the evidence-based practices, lay the foundation for improving effectiveness of “evidence-based practices and treatments,” and provide a work environment that supports evidence-based practices and treatments. This article outlines a research agenda to build implementation knowledge that can further the use of evidence-based practices and treatments.

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Four million newborn deaths: Is the global research agenda evidence-based?

Early Human Development ◽

10.1016/j.earlhumdev.2008.09.009 ◽

2008 ◽

Vol 84 (12) ◽

pp. 809-814 ◽

Cited By ~ 21

Author(s):

Joy E. Lawn ◽

Igor Rudan ◽

Craig Rubens

Keyword(s):

Research Agenda ◽

Evidence Based ◽

Global Research

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Social Network Analysis (SNA) of Salvage Therapies in Multiple Myeloma (MM)

Blood ◽

10.1182/blood.v120.21.4239.4239 ◽

2012 ◽

Vol 120 (21) ◽

pp. 4239-4239

Author(s):

Helen Mahony ◽

Athanasios Tsalatsanis ◽

Rahul Mhaskar ◽

Ambuj Kumar ◽

Benjamin Djulbegovic

Keyword(s):

Salvage Therapy ◽

Research Agenda ◽

Standard Treatment ◽

Single Agent ◽

Research Network ◽

Phase Iii ◽

Novel Agents ◽

Evidence Based ◽

Treatment Network ◽

American Society

Abstract Abstract 4239 Background: In order to evaluate the evolution of therapies used in randomized controlled trials (RCTs), these treatments can be viewed as a treatment network. Using SNA allows us to examine the relationships and importance among different treatments in the network. Currently, there is no standard treatment regimen for patients with relapsed or refractory MM. Furthermore, the lack of a directed research agenda among RCTs of salvage therapy makes it difficult to produce evidence-based treatment guidelines. Our goal is to analyze the research network of RCTs studying salvage therapies among patients with MM using SNA which is anticipated to assist in directing future research. Methods: MEDLINE (PubMed), abstracts from the American Society of Hematology and American Society of Clinical Oncology were searched to July 2012 to identify all phase III RCTs of salvage therapy among patients with MM. Data on treatments used for the experimental and standard arm and sample size were extracted. A treatment network was created from the treatments in the included RCTs. The analysis included calculation of the following SNA measures: constraint, size, 2StepReach, and degree. Data were analyzed with UCINET 6 and figures were created with NetDraw 2.119. Results: Twenty-six RCTs enrolling a total of 6627 patients were included. The majority (54%) of the trials enrolled less than 150 patients. The treatment network (Figure) is fragmented with 3 prominent sub-networks and 5 isolates with 2 to 3 treatments. This fragmentation indicates that there is no communication among these sub-networks and isolates. Sub-network A is created around VAD treatment and is mostly of historical importance. Sub-network B is created between treatments compared to single agent Bort or DEX and sub-network C on treatments compared to combination Bort-DEX. Sub-network C contains the only head-to-head comparisons of novel agents (Thal versus Bort and Bort plus Thal versus Thal). The metrics for the treatments contained in sub-networks B and C are shown in the Table. Bort, DEX, and combination Bort-DEX have low constraint values indicating ample experimentation between treatments within their respective sub-networks. In contrast, Thal-Low and Thal-high have high values of constraint indicating that these treatments are rather isolated from the rest of their sub-network. Single agent DEX and Bort have the largest networks (6 and 4 nodes respectively) since they were most often used as standard treatment. This can also be seen in the Figure where the nodes for DEX and Bort are much larger compared to the other nodes in their network. This is further confirmed by the 2StepReach analysis where single agent DEX and Bort are able to reach the largest number of nodes within two “steps” compared to other treatments within their network. Conclusion: The geometry of the treatment network demonstrates the fragmented and unorganized evolution of salvage therapies in MM. Most recently single agent Bort and DEX and combination Bort-DEX have been used most frequently as the standard comparison in RCTs. However, there were only two head-to-head comparisons of novel agents (Thal versus Bort and Bort plus Thal versus Thal). Using SNA can aid researchers in developing a more focused research agenda which will facilitate the development of evidence-based guidelines for salvage therapy among patients with MM. Disclosures: No relevant conflicts of interest to declare.

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Neuroimaging and Disorders of Consciousness: Envisioning an Ethical Research Agenda

The American Journal of Bioethics ◽

10.1080/15265160802318113 ◽

2008 ◽

Vol 8 (9) ◽

pp. 3-12 ◽

Cited By ~ 61

Author(s):

Joseph J. Fins∗ ◽

Judy Illes∗ ◽

James L. Bernat∗∗ ◽

Joy Hirsch∗∗ ◽

Steven Laureys∗∗ ◽

...

Keyword(s):

Research Agenda ◽

Disorders Of Consciousness ◽

Ethical Research

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