Sex differences in human brain asymmetry

1976 ◽  
Author(s):  
Jeannette McGlone
Keyword(s):  
Sex Differences ◽  
Human Brain ◽  
Brain Asymmetry

scholarly journals Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain masculinization

2021 ◽  
Author(s):  
Zhiqiang Sha ◽  
Dick Schijven ◽  
Clyde Francks
Keyword(s):  
Sex Differences ◽  
Executive Functions ◽  
Autism Spectrum ◽  
Brain Asymmetry ◽  
Risk Scores ◽  
Imaging Data ◽  
Polygenic Risk ◽  
Left Right Asymmetry ◽  
The Uk ◽  
The Brain

AbstractAutism spectrum disorder (ASD) and schizophrenia have been conceived as partly opposing disorders in terms of systemizing versus empathizing cognitive styles, with resemblances to male versus female average sex differences. Left-right asymmetry of the brain is an important aspect of its organization that shows average differences between the sexes, and can be altered in both ASD and schizophrenia. Here we mapped multivariate associations of polygenic risk scores (PRS) for ASD and schizophrenia with asymmetries of regional cerebral cortical surface area, thickness and subcortical volume measures in 32,256 participants from the UK Biobank. PRS for the two disorders were positively correlated (r=0.08, p=7.13×10−50), and both were higher in females compared to males, consistent with biased participation against higher-risk males. Each PRS was associated with multivariate brain asymmetry after adjusting for sex, ASD PRS r=0.03, p=2.17×10−9, schizophrenia PRS r=0.04, p=2.61×10−11, but the multivariate patterns were mostly distinct for the two PRS, and neither resembled average sex differences. Annotation based on meta-analyzed functional imaging data showed that both PRS were associated with asymmetries of regions important for language and executive functions, consistent with behavioural associations that arose in phenome-wide association analysis. Overall, the results indicate that distinct patterns of subtly altered brain asymmetry may be functionally relevant manifestations of polygenic risk for ASD and schizophrenia, but do not support brain masculinization or feminization in their etiologies.

Brain asymmetry, immunity, handedness

Open Medicine ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Zlatislav Stoyanov ◽  
Lyoubka Decheva ◽  
Irina Pashalieva ◽  
Piareta Nikolova
Keyword(s):  
Immune Response ◽  
Human Brain ◽  
Right Hemisphere ◽  
Functional Organization ◽  
Brain Asymmetry ◽  
Internal Environment ◽  
Living Nature ◽  
Left Right Asymmetry ◽  
The Right

AbstractThe principle of symmetry-asymmetry is widely presented in the structural and functional organization of the nonliving and living nature. One of the most complex manifestations of this principle is the left-right asymmetry of the human brain. The present review summarizes previous and contemporary literary data regarding the role of brain asymmetry in neuroimmunomodulation. Some handedness-related peculiarities are outlined additionally. Brain asymmetry is considered to be imprinted in the formation and regulation of the individual’s responses and relationships at an immunological level with the external and internal environment. The assumptions that the hemispheres modulate immune response in an asymmetric manner have been confirmed in experiments on animals. Some authors assume that the right hemisphere plays an indirect role in neuroimmunomodulation, controlling and suppressing the left hemispheric inductive signals.

Development of sex differences in the human brain

2020 ◽  
pp. 1-8
Author(s):  
Florian Kurth ◽  
Christian Gaser ◽  
Eileen Luders
Keyword(s):  
Sex Differences ◽  
Human Brain

Regional sex differences in grey matter volume are associated with sex hormones in the young adult human brain

NeuroImage ◽  
2010 ◽  
Vol 49 (2) ◽  
pp. 1205-1212 ◽  
Author(s):  
A. Veronica Witte ◽  
Markus Savli ◽  
Alexander Holik ◽  
Siegfried Kasper ◽  
Rupert Lanzenberger
Keyword(s):  
Sex Differences ◽  
Young Adult ◽  
Human Brain ◽  
Sex Hormones ◽  
Grey Matter ◽  
Grey Matter Volume ◽  
Adult Human Brain ◽  
Matter Volume ◽  
Adult Human

scholarly journals Neurophysiological origin of human brain asymmetry for speech and language

2010 ◽  
Vol 107 (43) ◽  
pp. 18688-18693 ◽  
Author(s):  
B. Morillon ◽  
K. Lehongre ◽  
R. S. J. Frackowiak ◽  
A. Ducorps ◽  
A. Kleinschmidt ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Asymmetry ◽  
Speech And Language

scholarly journals Mapping the Stability of Human Brain Asymmetry across Five Sex-Chromosome Aneuploidies

2015 ◽  
Vol 35 (1) ◽  
pp. 140-145 ◽  
Author(s):  
A. Lin ◽  
L. Clasen ◽  
N. R. Lee ◽  
G. L. Wallace ◽  
F. Lalonde ◽  
...  
Keyword(s):  
Human Brain ◽  
Sex Chromosome ◽  
Brain Asymmetry ◽  
The Stability ◽  
Sex Chromosome Aneuploidies
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