Modulation of ethanol reinforcement by Pavlovian conditioned tolerance

1991 ◽  
Author(s):  
Christopher L. Cunningham
Keyword(s):  
Ethanol Reinforcement ◽  
Conditioned Tolerance

scholarly journals Sex Differences in the Reward-Enhancing Effects of Nicotine on Ethanol Reinforcement: A Reinforcer Demand Analysis

2019 ◽  
Vol 22 (2) ◽  
pp. 238-247 ◽  
Author(s):  
Scott T Barrett ◽  
Brady M Thompson ◽  
Jessica R Emory ◽  
Chris E Larsen ◽  
Steven T Pittenger ◽  
...  
Keyword(s):  
Alcohol Abuse ◽  
Ethanol Solution ◽  
Female Rats ◽  
Demand Model ◽  
Self Administration ◽  
Biological Sex ◽  
Ethanol Reinforcement ◽  
Nicotine Abuse ◽  
Reinforcer Demand ◽  
Reinforcement Value

Abstract Background Alcohol is often consumed with tobacco, and dependence to alcohol and tobacco are highly comorbid. In addition, there are differences in the prevalence of nicotine- and alcohol-abuse between the sexes. Nicotine produces enhancing effects on the value of other reinforcers, which may extend to alcohol. Methods Male and female Wistar rats were trained to self-administer 15% ethanol solution in 30-minute sessions. Once ethanol self-administration was established, demand for ethanol was evaluated using an exponential reinforcer demand method, in which the response cost per reinforcer delivery was systematically increased over blocks of several sessions. Within each cost condition, rats were preinjected with nicotine (0.05, 0.1, 0.2, or 0.4 mg/kg base, SC) or saline 5 minutes before self-administration sessions. The effects of nicotine dose and biological sex were evaluated using the estimates generated by the reinforcer demand model. Results Under saline conditions, males showed greater sensitivity to ethanol reinforcement than females. Nicotine enhanced the reinforcement value of alcohol and this varied with sex. In both sexes, 0.4 mg/kg nicotine decreased intensity of ethanol demand. However, 0.05, 0.1, and 0.2 mg/kg nicotine decreased elasticity of ethanol demand in females, but not in males. Conclusions Nicotine enhances ethanol reinforcement, which may partially drive comorbidity between nicotine-abuse and alcohol-abuse. Males showed signs of greater ethanol reinforcement value than females under saline conditions, and nicotine attenuated this effect by increasing ethanol reinforcement value in the females. These findings highlight that a complete understanding of alcohol-abuse must include a thorough study of alcohol use in the context of other drug use, including nicotine. Implications Nicotine dose dependently enhances the alcohol reinforcement value in a manner that is clearly influenced by biological sex. Under saline baseline conditions, males show lower elasticity of demand for alcohol reinforcement than females, indicative of greater reinforcement value. However, nicotine attenuated this difference by enhancing alcohol reward in the females. Specifically, low-to-moderate doses (0.05–0.2 mg/kg) of nicotine decreased elasticity of alcohol demand in female rats, increasing the perseverance of their alcohol taking behavior. These data indicate that the well-documented reward-enhancing effects of nicotine on sensory reinforcement extend to alcohol reinforcement and that these vary with biological sex.

Conditioned tolerance to the anorectic and corticosterone-elevating effects of nicotine

1991 ◽  
Vol 40 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Anthony R. Caggiula ◽  
Leonard H. Epstein ◽  
Seymour M. Antelman ◽  
Saundra S. Saylor ◽  
Kenneth A. Perkins ◽  
...  
Keyword(s):  
Conditioned Tolerance

The role of acetaldehyde in ethanol reinforcement assessed by Pavlovian conditioning in newborn rats

2012 ◽  
Vol 226 (3) ◽  
pp. 491-499 ◽  
Author(s):  
Samanta M. March ◽  
Paula Abate ◽  
Norman E. Spear ◽  
Juan Carlos Molina
Keyword(s):  
Pavlovian Conditioning ◽  
Newborn Rats ◽  
Ethanol Reinforcement

Possible Substrates of Ethanol Reinforcement: GABA and Dopamine

1992 ◽  
Vol 654 (1 The Neurobiol) ◽  
pp. 61-69 ◽  
Author(s):  
R. ADRON HARRIS ◽  
MARK S. BRODIE ◽  
THOMAS V. DUNWIDDIE
Keyword(s):  
Ethanol Reinforcement

Electrophysiological Correlates of Ethanol Reinforcement

1991 ◽  
pp. 201-231 ◽  
Author(s):  
Scott E. Lukas ◽  
Jack H. Mendelson ◽  
Leslie Amass ◽  
Richard A. Benedikt ◽  
John N. Henry ◽  
...  
Keyword(s):  
Ethanol Reinforcement
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