Lead Burden and ADHD Symptoms in Children and Adolescents: A Meta-Analysis

2012 ◽  
Author(s):  
James K. Goodlad ◽  
David K. Marcus ◽  
Jessica J. Fulton
Keyword(s):  
Children And Adolescents ◽  
Meta Analysis ◽  
Adhd Symptoms

Core ADHD Symptom Improvement With Atomoxetine Versus Methylphenidate

2010 ◽  
Vol 15 (8) ◽  
pp. 674-683 ◽  
Author(s):  
Philip L. Hazell ◽  
Michael R. Kohn ◽  
Ruth Dickson ◽  
Richard J. Walton ◽  
Renee E. Granger ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Adhd Symptom ◽  
Rating Scale ◽  
Meta Analysis ◽  
Absolute Difference ◽  
Comparable Efficacy ◽  
Symptom Improvement ◽  
Adhd Symptoms ◽  
Symptom Response ◽  
Noninferiority Margin

Objective: Previous studies comparing atomoxetine and methylphenidate to treat ADHD symptoms have been equivocal. This noninferiority meta-analysis compared core ADHD symptom response between atomoxetine and methylphenidate in children and adolescents. Method: Selection criteria included randomized, controlled design; duration 6 weeks; and assessment of ADHD Rating Scale–IV–Parent Version: Investigator Administered and Scored (ADHDRS) scores. Six-week response rates, defined as ≥40% reduction in ADHDRS total score, were compared using a noninferiority margin of −15%. Results: Seven studies met inclusion criteria ( N = 1,368). After 6 weeks, 53.6% (95% confidence interval [CI] 48.6%-58.4%) of atomoxetine-treated patients ( n = 811) had responded compared with 54.4% (47.6%-61.1%) for methylphenidate ( n = 557), with atomoxetine demonstrating noninferiority to methylphenidate (absolute difference −0.9%, 95% CI −9.2%-7.5%). Conclusion: After 6 weeks of treatment atomoxetine and methylphenidate had comparable efficacy in reducing core ADHD symptoms in children and adolescents.

scholarly journals The association of inadequate lip coverage and malocclusion with dental trauma in Brazilian children and adolescents – A systematic review and meta‐analysis

2021 ◽  
Author(s):  
Walbert de Andrade Vieira ◽  
Vanessa Gallego Arias Pecorari ◽  
Paulo Henrique Gabriel ◽  
Júlio Vargas‐Neto ◽  
Eduardo César Almada Santos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Children And Adolescents ◽  
Meta Analysis ◽  
Dental Trauma ◽  
Brazilian Children
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