Autocontrol of internal states

1971 ◽  
Author(s):  
Joe Kamiya ◽  
Earl C. Brown ◽  
Lester G. Fehmi ◽  
Alyce M. Green ◽  
Elmer E. Green ◽  
...  
Keyword(s):  
Internal States

Subjective Fear Dilutes as Group Size Increases

2020 ◽  
Author(s):  
dean mobbs ◽  
Ellen Tedeschi ◽  
Anastasia Buyalskaya ◽  
Brian Silston
Keyword(s):  
Group Size ◽  
Real World ◽  
Survival Benefit ◽  
Group Living ◽  
External Factors ◽  
Threat Perception ◽  
Perception Of Threat ◽  
Threat Level ◽  
Internal States ◽  
Risk Dilution

According to Hamilton’s Selfish Herd Theory, a crucial survival benefit of group living is that it provides a ‘risk dilution’ function against predation. Despite a large literature on group living benefits in animals, few studies have been conducted on how group size alters subjective fear or threat perception in humans, and on what factors drive preferences for being in groups when facing threats. We conducted seven experiments (N=3,838) to test (A) if the presence of others decreases perception of threat under a variety of conditions. In studies 1 to 3, we experimentally manipulated group size in hypothetical and real-world situations, to show that fear responses decreased as group size increased. In studies 4 to 7 we again used a combination of hypothetical, virtual and real-world decisions to test (B) how internal states (e.g. anxiety) and external factors (e.g. threat level, availability of help) affected participants’ preference for groups. Participants consistently chose larger groups when threat and anxiety were high. Overall, our findings show that group size provides a salient signal of protection and safety.

scholarly journals Loss of mGluR5 in D1 Receptor-Expressing Neurons Improves Stress Coping

2021 ◽  
Vol 22 (15) ◽  
pp. 7826
Author(s):  
Luca Zangrandi ◽  
Claudia Schmuckermair ◽  
Hussein Ghareh ◽  
Federico Castaldi ◽  
Regine Heilbronn ◽  
...  
Keyword(s):  
Stress Responses ◽  
Metabotropic Glutamate Receptor ◽  
Forced Swim Test ◽  
Functional Integration ◽  
D1 Receptor ◽  
Conditional Knockout ◽  
Stress Coping ◽  
Metabotropic Glutamate ◽  
Internal States

The metabotropic glutamate receptor type 5 (mGluR5) has been proposed to play a crucial role in the selection and regulation of cognitive, affective, and emotional behaviors. However, the mechanisms by which these receptors mediate these effects remain largely unexplored. Here, we studied the role of mGluR5 located in D1 receptor-expressing (D1) neurons in the manifestation of different behavioral expressions. Mice with conditional knockout (cKO) of mGluR5 in D1 neurons (mGluR5D1 cKO) and littermate controls displayed similar phenotypical profiles in relation to memory expression, anxiety, and social behaviors. However, mGluR5D1 cKO mice presented different coping mechanisms in response to acute escapable or inescapable stress. mGluR5D1 cKO mice adopted an enhanced active stress coping strategy upon exposure to escapable stress in the two-way active avoidance (TWA) task and a greater passive strategy upon exposure to inescapable stress in the forced swim test (FST). In summary, this work provides evidence for a functional integration of the dopaminergic and glutamatergic system to mediate control over internal states upon stress exposure and directly implicates D1 neurons and mGluR5 as crucial mediators of behavioral stress responses.

scholarly journals How Experts React: The World Health Organization’s Appraisal of COVID-19 via Communication Patterns

2021 ◽  
pp. 0261927X2110263
Author(s):  
David M. Markowitz
Keyword(s):  
World Health Organization ◽  
Cognitive Processing ◽  
Communication Patterns ◽  
World Health ◽  
Working Through ◽  
The World ◽  
Internal States ◽  
Health Organization ◽  
The Relationship ◽  
Health Experts

How do COVID-19 experts psychologically manage the pandemic and its effects? Using a full year of press briefings (January 2020–January 2021) from the World Health Organization ( N = 126), this paper evaluated the relationship between communication patterns and COVID-19 cases and deaths. The data suggest as COVID-19 cases and deaths increased, health experts tended to think about the virus in a more formal and analytic manner. Experts also communicated with fewer cognitive processing terms, which typically indicate people “working through” a crisis. This report offers a lens into the internal states of COVID-19 experts and their organization as they gradually learned about the virus and its daily impact.

Impaired discrimination of a subanesthetic dose of ketamine in a maternal immune activation model of schizophrenia risk

2021 ◽  
pp. 026988112110297
Author(s):  
Wayne Meighan ◽  
Thomas W Elston ◽  
David Bilkey ◽  
Ryan D Ward
Keyword(s):  
Animal Models ◽  
Drug Discrimination ◽  
Immune Activation ◽  
Internal State ◽  
Nmda Receptor Antagonist ◽  
Activation Model ◽  
Data Link ◽  
Maternal Immune Activation ◽  
Internal States ◽  
Reliable Methods

Background: Animal models of psychiatric diseases suffer from a lack of reliable methods for accurate assessment of subjective internal states in nonhumans. This gap makes translation of results from animal models to patients particularly challenging. Aims/methods: Here, we used the drug-discrimination paradigm to allow rats that model a risk factor for schizophrenia (maternal immune activation, MIA) to report on the subjective internal state produced by a subanesthetic dose of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine. Results/outcomes: The MIA rats’ discrimination of ketamine was impaired relative to controls, both in the total number of rats that acquired and the asymptotic level of discrimination accuracy. This deficit was not due to a general inability to learn to discriminate an internal drug cue or internal state generally, as MIA rats were unimpaired in the learning and acquisition of a morphine drug discrimination and were as sensitive to the internal state of satiety as controls. Furthermore, the deficit was not due to a decreased sensitivity to the physiological effects of ketamine, as MIA rats showed increased ketamine-induced locomotor activity. Finally, impaired discrimination of ketamine was only seen at subanesthetic doses which functionally correspond to psychotomimetic doses in humans. Conclusion: These data link changes in NMDA responses to the MIA model. Furthermore, they confirm the utility of the drug-discrimination paradigm for future inquiries into the subjective internal state produced in models of schizophrenia and other developmental diseases.

Energy redistribution among internal states of nitric oxide molecules upon scattering from Pt(111) crystal surface

1983 ◽  
Vol 78 (11) ◽  
pp. 6992-7004 ◽  
Author(s):  
M. Asscher ◽  
W. L. Guthrie ◽  
T.‐H. Lin ◽  
G. A. Somorjai
Keyword(s):  
Nitric Oxide ◽  
Crystal Surface ◽  
Energy Redistribution ◽  
Internal States

scholarly journals On Robust State Estimation of Gene Networks

2010 ◽  
Vol 2 ◽  
pp. 117959721000200 ◽  
Author(s):  
Chia-Hua Chuang ◽  
Chun-Liang Lin
Keyword(s):  
Parameter Estimation ◽  
Kalman Filter ◽  
Quantitative Analysis ◽  
State Estimation ◽  
Gene Networks ◽  
Gene Network ◽  
Biological Systems ◽  
Uncertain Process ◽  
Network Systems ◽  
Internal States

Gene networks in biological systems are not only nonlinear but also stochastic due to noise corruption. How to accurately estimate the internal states of the noisy gene networks is an attractive issue to researchers. However, the internal states of biological systems are mostly inaccessible by direct measurement. This paper intends to develop a robust extended Kalman filter for state and parameter estimation of a class of gene network systems with uncertain process noises. Quantitative analysis of the estimation performance is conducted and some representative examples are provided for demonstration.

Sign in / Sign up

Export Citation Format

Share Document