Introduction to body-energy therapies

The hypothalamic regulation of appetite governs whole-body energy balance. Satiety is regulated by endocrine factors including leptin, and impaired leptin signaling is associated with obesity. Despite the anorectic effect of leptin through the regulation of the hypothalamic feeding circuit, a distinct downstream mediator of leptin signaling in neuron remains unclear. Angiopoietin-like growth factor (AGF) is a peripheral activator of energy expenditure and antagonizes obesity. However, the regulation of AGF expression in brain and localization to mediate anorectic signaling is unknown. Here, we demonstrated that AGF is expressed in proopiomelanocortin (POMC)-expressing neurons located in the arcuate nucleus (ARC) of the hypothalamus. Unlike other brain regions, hypothalamic AGF expression is stimulated by leptin-induced signal transducers and activators of transcription 3 (STAT3) phosphorylation. In addition, leptin treatment to hypothalamic N1 cells significantly enhanced the promoter activity of AGF. This induction was abolished by the pretreatment of ruxolitinib, a leptin signaling inhibitor. These results indicate that hypothalamic AGF expression is induced by leptin and colocalized to POMC neurons.

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Fourier transform infrared spectroscopy of milk samples as a tool to estimate energy balance, energy- and dry matter intake in lactating dairy cows

Journal of Dairy Research ◽

10.1017/s0022029920001004 ◽

2020 ◽

pp. 1-8

Author(s):

Amira Rachah ◽

Olav Reksen ◽

Nils Kristian Afseth ◽

Valeria Tafintseva ◽

Sabine Ferneborg ◽

...

Keyword(s):

Dairy Cows ◽

Dry Matter ◽

External Validation ◽

Ftir Spectra ◽

Dry Matter Intake ◽

Energy Status ◽

Test Set ◽

Milk Samples ◽

External Test ◽

Body Energy

Abstract The objective of the study was to evaluate the potential of Fourier transform infrared spectroscopy (FTIR) analysis of milk samples to predict body energy status and related traits (energy balance (EB), dry matter intake (DMI) and efficient energy intake (EEI)) in lactating dairy cows. The data included 2371 milk samples from 63 Norwegian Red dairy cows collected during the first 105 days in milk (DIM). To predict the body energy status traits, calibration models were developed using Partial Least Squares Regression (PLSR). Calibration models were established using split-sample (leave-one cow-out) cross-validation approach and validated using an external test set. The PLSR method was implemented using just the FTIR spectra or using the FTIR together with milk yield (MY) or concentrate intake (CONCTR) as predictors of traits. Analyses were conducted for the entire first 105 DIM and separately for the two lactation periods: 5 ≤ DIM ≤ 55 and 55 < DIM ≤ 105. To test the models, an external validation using an independent test set was performed. Predictions depending on the parity (1st, 2nd and 3rd-to 6th parities) in early lactation were also investigated. Accuracy of prediction (r) for both cross-validation and external test set was defined as the correlation between the predicted and observed values for body energy status traits. Analyzing FTIR in combination with MY by PLSR, resulted in relatively high r-values to estimate EB (r = 0.63), DMI (r = 0.83), EEI (r = 0.84) using an external validation. Only moderate correlations between FTIR spectra and traits like EB, EEI and dry matter intake (DMI) have so far been published. Our hypothesis was that improvements in the FTIR predictions of EB, EEI and DMI can be obtained by (1) stratification into different stages of lactations and different parities, or (2) by adding additional information on milking and feeding traits. Stratification of the lactation stages improved predictions compared with the analyses including all data 5 ≤ DIM ≤105. The accuracy was improved if additional data (MY or CONCTR) were included in the prediction model. Furthermore, stratification into parity groups, improved the predictions of body energy status. Our results show that FTIR spectral data combined with MY or CONCTR can be used to obtain improved estimation of body energy status compared to only using the FTIR spectra in Norwegian Red dairy cattle. The best prediction results were achieved using FTIR spectra together with MY for early lactation. The results obtained in the study suggest that the modeling approach used in this paper can be considered as a viable method for predicting an individual cow's energy status.

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Simulation and Analysis on Pressure Resistance Experiments of Automotive Body

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.490-495.1451 ◽

2012 ◽

Vol 490-495 ◽

pp. 1451-1455

Author(s):

Guang Yao Zhao ◽

Yi Feng Zhao ◽

Chuan Yin Tang ◽

Zhi Yuan Du

Keyword(s):

Energy Absorption ◽

The Body ◽

Original Design ◽

Element Analysis ◽

Vehicle Simulation ◽

Automotive Body ◽

Safety Regulations ◽

Vehicle Rollover ◽

Pressure Resistance ◽

Body Energy

Aimed at SUV-type vehicle, simulation and analysis of pressure resistance experiments on the body of automobile has been presented in the paper, according to the vehicle safety regulations and standards of FMVSS216. A limited SUV vehicle model is created; simulation is obtained with the help of software LS-DYNA, based on the principle of finite element analysis method. Assessment of pressure resistance and safety of the automobile has been presented, from the aspect of the deformation of body, the energy absorption of the vehicle and components, and the pressure on the body, etc. By rational improving of the original design of body structure, the reasonable distribution of pressure absorbability of the body of the SUV-type automobile is achieved. The effect of the overall energy absorption of the body is fully exerted, and then the safety of the driver and the passenger in a rollover accident is improved. Research methods and conclusions of this paper provide useful ways and references to the research of the safety of vehicle rollover and design of rationality of body energy absorption

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Effect of fish meal on the mobilization of body energy in dairy cows

Animal Science ◽

10.1017/s000335610000283x ◽

1987 ◽

Vol 45 (3) ◽

pp. 345-348 ◽

Cited By ~ 39

Author(s):

E. R. Ørskov ◽

G. W. Reid ◽

C. A. G. Tait

Keyword(s):

Fish Meal ◽

Energy Requirement ◽

Metabolizable Energy ◽

Early Lactation ◽

Protein Supplements ◽

Treatment Groups ◽

Fat Mobilization ◽

Four Levels ◽

Metabolizable Energy Intake ◽

Body Energy

ABSTRACTThirty-two Friesian cows in early lactation were divided into four treatment groups to receive ad libitum a mixed diet consisting of silage (0·70) and grain-based concentrate (0·30). Fish meal was subsequently mixed into the diet at levels of 0, 40, 80 and 120 g/kg to provide crude protein concentration (g/kg dry matter) in the complete diets of 156, 181, 200 and 212 respectively. In the 2nd week after calving the yields of fat-corrected milk (FCM) were 28·5, 29·2, 32·0 and 34·9 kg/day for the four levels respectively; at this time, food intake was sufficient only to meet the calculated energy requirement for 15 kg FCM per day. Due to recurring problems with ketosis on the diet containing 120 g fish meal per kg, this treatment was terminated and the experiment continued for 15 weeks with the groups receiving 0, 40 and 80 g/kg fish meal supplements. During this time average yields of FCM were 23·5, 25·6 and 28-0 kg FCM per day respectively and energy intakes were calculated to be sufficient to meet the requirement for 18 kg FCM per day.It appeared possible to increase milk yield by stimulating fat mobilization through giving undegraded protein supplements to underfed cows in early lactation. However, when an excessive mobilization occurred with a high supplement, and when the animals were yielding 15 to 20 kg FCM more than their metabolizable energy intake was calculated to sustain, some cows became ketotic.

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Ambient temperature effects on physiological traits of white-tailed deer

Canadian Journal of Zoology ◽

10.1139/z75-082 ◽

1975 ◽

Vol 53 (6) ◽

pp. 679-685 ◽

Cited By ~ 11

Author(s):

J. B. Holter ◽

W. E. Urban Jr. ◽

H. H. Hayes ◽

H. Silver ◽

H. R. Skutt

Keyword(s):

Heart Rate ◽

Body Temperature ◽

Energy Expenditure ◽

Ambient Temperature ◽

Temperature Effects ◽

Temperature Changes ◽

Wind Chill ◽

Ambient Temperatures ◽

Energy Equilibrium ◽

Body Energy

Six adult white-tailed deer (Odocoileus virginianus borealis) were exposed to 165 periods of 12 consecutive hours of controlled constant ambient temperature in an indirect respiration calorimeter. Temperatures among periods varied from 38 to 0 (summer) or to −20C (fall, winter, spring). Traits measured were energy expenditure (metabolic rate), proportion of time spent standing, heart rate, and body temperature, the latter two using telemetry. The deer used body posture extensively as a means of maintaining body energy equilibrium. Energy expenditure was increased at low ambient temperature to combat cold and to maintain relatively constant body temperature. Changes in heart rate paralleled changes in energy expenditure. In a limited number of comparisons, slight wind chill was combatted through behavioral means with no effect on energy expenditure. The reaction of deer to varying ambient temperatures was not the same in all seasons of the year.

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Effect of starch on the utilization by sheep of a straw diet supplemented with urea and minerals

Australian Journal of Agricultural Research ◽

10.1071/ar9760139 ◽

1976 ◽

Vol 27 (1) ◽

pp. 139 ◽

Cited By ~ 19

Author(s):

JG Mulholland ◽

JB Coombe ◽

WR McManus

Keyword(s):

Organic Matter ◽

Nitrogen Retention ◽

Nitrogen Excretion ◽

Digestible Organic Matter ◽

Cellulose Digestibility ◽

Oat Straw ◽

Total Body ◽

Body Energy ◽

Urinary Nitrogen Excretion ◽

Urinary Nitrogen

Individually penned Border Leicester x Merino wethers, aged 11 months, were fed ad lib. for 16 weeks on a basal ration of ground, pelleted oat straw, urea and minerals, supplemented with 0, 5, 10, 15, 20, 30 or 40% starch. The diets contained equal percentages of nitrogen and minerals. Dry matter intake reached a maximum of 2000 g/day with 30% starch; above this starch level, digestive disturbances were observed. Organic matter digestibility was increased by the addition of starch, but cellulose digestibility was depressed by as much as 18 units with the addition of 30% starch. Up to 10% the starch level had little effect on cellulose digestibility. Liveweight change was significantly correlated with digestible organic matter intake, mean daily weight gains varying from 22 g with no starch to 104 g with 30% starch. However, a large percentage of the liveweight gain was as total body water, and body energy storage increased appreciably only when the diet contained at least 20% starch. The inclusion of 5% starch slightly depressed both intake and liveweight gain. Daily clean wool production was significantly increased at starch levels higher than 20% and ranged from 5.3 to 7.5 g/day with 0 and 40% starch respectively. Increasing levels of starch had little effect on apparent nitrogen digestibility, but resulted in a substantial increase in nitrogen retention through a reduction in urinary nitrogen excretion. Serum urea levels fell from a mean of 42 mg/100 ml during the first week to 31 mg/100 ml during subsequent periods, with no significant differences between diets. With the general exception of potassium, mineral balances were positive or close to zero throughout the experiment.

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Exercise and MEF2–HDAC interactions

Applied Physiology Nutrition and Metabolism ◽

10.1139/h07-082 ◽

2007 ◽

Vol 32 (5) ◽

pp. 852-856 ◽

Cited By ~ 21

Author(s):

Sean L. McGee

Keyword(s):

Skeletal Muscle ◽

Protein Kinase ◽

Nuclear Export ◽

Energy Homeostasis ◽

Whole Body ◽

Positive Health ◽

Exercise Induced ◽

Amp Activated Protein Kinase ◽

Body Energy ◽

Skeletal Muscle Adaptations

Exercise increases the metabolic capacity of skeletal muscle, which improves whole-body energy homeostasis and contributes to the positive health benefits of exercise. This is, in part, mediated by increases in the expression of a number of metabolic enzymes, regulated largely at the level of transcription. At a molecular level, many of these genes are regulated by the class II histone deacetylase (HDAC) family of transcriptional repressors, in particular HDAC5, through their interaction with myocyte enhancer factor 2 transcription factors. HDAC5 kinases, including 5′-AMP-activated protein kinase and protein kinase D, appear to regulate skeletal muscle metabolic gene transcription by inactivating HDAC5 and inducing HDAC5 nuclear export. These mechanisms appear to participate in exercise-induced gene expression and could be important for skeletal muscle adaptations to exercise.

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