The role of immersive 3D environments in three-dimensional mental rotation

2008 ◽  
Author(s):  
Maria Kozhevnikov
Keyword(s):  
Mental Rotation ◽  
Three Dimensional ◽  
3D Environments

scholarly journals Fibronectin Matrix Assembly Regulates α5β1-mediated Cell Cohesion

2004 ◽  
Vol 15 (3) ◽  
pp. 973-981 ◽  
Author(s):  
Elizabeth E. Robinson ◽  
Ramsey A. Foty ◽  
Siobhan A. Corbett
Keyword(s):  
Three Dimensional ◽  
Cell Aggregation ◽  
Alternative Mechanism ◽  
Matrix Assembly ◽  
Integrin Α4 ◽  
3D Environments ◽  
Cellular Aggregates ◽  
Α5β1 Integrin ◽  
Cells Cultured

Integrin-extracellular matrix (ECM) interactions in two-dimensional (2D) culture systems are widely studied (Goldstein and DiMilla, 2002. J Biomed. Mater. Res. 59, 665–675; Koo et al., 2002. J. Cell Sci. 115, 1423–1433). Less understood is the role of the ECM in promoting intercellular cohesion in three-dimensional (3D) environments. We have demonstrated that the α5β1-integrin mediates strong intercellular cohesion of 3D cellular aggregates (Robinson et al., 2003. J. Cell Sci. 116, 377–386). To further investigate the mechanism of α5β1-mediated cohesivity, we used a series of chimeric α5β1-integrin–expressing cells cultured as multilayer cellular aggregates. In these cell lines, the α5 subunit cytoplasmic domain distal to the GFFKR sequence was truncated, replaced with that of the integrin α4, the integrin α2, or maintained intact. Using these cells, α5β1-integrin–mediated cell aggregation, compaction and cohesion were determined and correlated with FN matrix assembly. The data presented demonstrate that cells cultured in the absence of external mechanical support can assemble a FN matrix that promotes integrin-mediated aggregate compaction and cohesion. Further, inhibition of FN matrix assembly blocks the intercellular associations required for compaction, resulting in cell dispersal. These results demonstrate that FN matrix assembly contributes significantly to tissue cohesion and represents an alternative mechanism for regulating tissue architecture.

The Role of Immersivity in Three-Dimensional Mental Rotation

2008 ◽  
pp. 143-157 ◽  
Author(s):  
Maria Kozhevnikov ◽  
Jodie Royan ◽  
Olesya Blazhenkova ◽  
Andrey Gorbunov
Keyword(s):  
Mental Rotation ◽  
Three Dimensional

The Role of Three-Dimensional Imaging in Evaluation of the Sinonasal Mass

1996 ◽  
Vol 34 (1) ◽  
pp. 27
Author(s):  
Sue Yon Shim ◽  
Ki Joon Sung ◽  
Young Ju Kim ◽  
In Soo Hong ◽  
Myung Soon Kim ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Three Dimensional Imaging ◽  
Sinonasal Mass

Homogenization and Mass Identity vs. Individual Identity. An Analysis in the Light of the Theory of “The Three Dimensional Spiral of Sense

2016 ◽  
Vol 2 (2) ◽  
pp. 40
Author(s):  
Miriam Aparicio
Keyword(s):  
Three Dimensional ◽  
Individual Identity ◽  
Cognitive Effects ◽  
The Media

This study tests some hypotheses included in the psycho-social-communicational paradigm, which emphasizes the cognitive effects of the media and the role of the psychosocial subject as the recipient

Dysregulation of HOX as a Potential Therapeutic Target in Breast Cancer

2020 ◽  
Vol 27 ◽  
Author(s):  
Ji-Yeon Lee ◽  
Myoung Hee Kim
Keyword(s):  
Breast Cancer ◽  
Hox Genes ◽  
Therapeutic Potential ◽  
Expression Patterns ◽  
Genome Structure ◽  
Control Cell ◽  
Three Dimensional ◽  
Cellular Processes ◽  
Hox Protein

: HOX genes belong to the highly conserved homeobox superfamily, responsible for the regulation of various cellular processes that control cell homeostasis, from embryogenesis to carcinogenesis. The abnormal expression of HOX genes is observed in various cancers, including breast cancer; they act as oncogenes or as suppressors of cancer, according to context. In this review, we analyze HOX gene expression patterns in breast cancer and examine their relationship, based on the three-dimensional genome structure of the HOX locus. The presence of non-coding RNAs, embedded within the HOX cluster, and the role of these molecules in breast cancer have been reviewed. We further evaluate the characteristic activity of HOX protein in breast cancer and its therapeutic potential.

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