The Effects of IV Gestational Nicotine Exposure on Adolescent Methamphetamine Sensitization and Brain-Derived Neurotrophic Factor (BDNF)

2010 ◽  
Author(s):  
Russell W. Brown ◽  
Benjamin A. Hughes ◽  
Ryan Lacy ◽  
Lauren Ballina ◽  
Steven B. Harrod
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Nicotine Exposure ◽  
Gestational Nicotine

scholarly journals Interactions of Glutamatergic Neurotransmission and Brain-Derived Neurotrophic Factor in the Regulation of Behaviors after Nicotine Administration

2019 ◽  
Vol 20 (12) ◽  
pp. 2943 ◽  
Author(s):  
Jieun Kim ◽  
Ju Hwan Yang ◽  
In Soo Ryu ◽  
Sumin Sohn ◽  
Sunghyun Kim ◽  
...  
Keyword(s):  
Nicotine Dependence ◽  
Nicotinic Acetylcholine Receptors ◽  
Neurotrophic Factor ◽  
Acetylcholine Receptors ◽  
Glutamate Release ◽  
Brain Derived Neurotrophic Factor ◽  
Nicotine Exposure ◽  
Glutamatergic Neurotransmission ◽  
Basal Nuclei ◽  
Nicotine Administration

Nicotine causes tobacco dependence, which may result in fatal respiratory diseases. The striatum is a key structure of forebrain basal nuclei associated with nicotine dependence. In the striatum, glutamate release is increased when α7 nicotinic acetylcholine receptors expressed in the glutamatergic terminals are exposed to nicotine, and over-stimulates glutamate receptors in gamma amino-butyric acid (GABA)ergic neurons. These receptor over-stimulations in turn potentiate GABAergic outputs to forebrain basal nuclei and contribute to the increase in psychomotor behaviors associated with nicotine dependence. In parallel with glutamate increases, nicotine exposure elevates brain-derived neurotrophic factor (BDNF) release through anterograde and retrograde targeting of the synapses of glutamatergic terminals and GABAergic neurons. This article reviews nicotine-exposure induced elevations of glutamatergic neurotransmission, the bidirectional targeting of BDNF in the striatum, and the potential regulatory role played by BDNF in behavioral responses to nicotine exposure.

Brain Derived Neurotrophic Factor Gene Polymorphism Associated With Language Acquisition

2007 ◽  
Author(s):  
Scott H. Fraundorf ◽  
Brad E. Sheese ◽  
Lauren K. White ◽  
Mary K. Rothbart ◽  
Michael I. Posner
Keyword(s):  
Language Acquisition ◽  
Gene Polymorphism ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Factor Gene
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