Progress in conflict prevention depends upon a better understanding of the underlying circumstances that give rise to violent conflict and mass atrocities, and of the warning signs that a crisis is imminent. While a substantial amount of empirical research on the driving forces of conflict exists, its policy implications must be exploited more effectively, so that the enabling conditions for violence can be addressed before it occurs. Violence prevention involves a range of social, economic, and political factors; the chapter highlights challenges—many of them international—relating to deprivation, inequality, governance, and environmental management. Prevention also requires overcoming a number of acute political obstacles embedded within the values and institutions of global governance. The chapter concludes with a range of proposals for structural conflict prevention and crisis response, as well as the prevention of mass atrocities.