Zinc blood levels during pregnancy don't seem to affect pregnancy complications or neonatal outcomes

2000 ◽  
Keyword(s):  
Pregnancy Complications ◽  
Neonatal Outcomes ◽  
Blood Levels

scholarly journals Maternal alcohol use, adverse neonatal outcomes and pregnancy complications in British Columbia, Canada: a population-based study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Svetlana Popova ◽  
Danijela Dozet ◽  
Graham O’Hanlon ◽  
Valerie Temple ◽  
Jürgen Rehm
Keyword(s):  
British Columbia ◽  
Risk Factor ◽  
Alcohol Use ◽  
Pregnancy Complications ◽  
Alcohol Exposure ◽  
Population Based ◽  
Neonatal Outcomes ◽  
Fiscal Year ◽  
Adverse Neonatal Outcomes ◽  
Icd 10

Abstract Background The current study aimed to estimate the prevalence of alcohol use identified as a risk factor during pregnancies by the antenatal care providers, resulting in live births in British Columbia (BC) and to examine associations between alcohol use, adverse neonatal outcomes, and pregnancy complications. Methods This population-based cross-sectional study utilized linked obstetrical and neonatal records within the BC Perinatal Data Registry (BCPDR), for deliveries that were discharged between January 1, 2015 and March 31, 2018. The main outcome measures were alcohol use identified as a risk factor during pregnancy, associated maternal characteristics, pregnancy complications, and adverse neonatal outcomes. Estimates for the period and fiscal year prevalence were calculated. Chi-square tests were used to compare adverse neonatal outcomes and pregnancy complications by alcohol use during pregnancy identified as a risk factor. Logistic regression was used to examine the association between alcohol use identified as a risk factor during pregnancy and adverse neonatal outcomes and pregnancy complications, after adjusting for identified risk factors. Results A total of 144,779 linked records within the BCPDR were examined. The period prevalence of alcohol use during pregnancy identified as a risk factor was estimated to be 1.1% and yearly prevalence was 1.1, 1.1, 1.3 and 0.9% from the 2014/2015 to 2017/2018 fiscal years, respectively. Alcohol use identified as a risk factor was associated with younger maternal age, fewer antenatal visits, being primiparous, a history of mental illness, substance use and smoking. Neonates with alcohol use during pregnancy identified as a risk factor had greater odds of being diagnosed with: “low birth weight (1000-2499g)” (ICD-10: P07.1; aOR = 1.25; 95% CI: 1.01, 1.53), “other respiration distress of newborn” (ICD-10: P22.8; aOR = 2.57; 95% CI: 1.52, 4.07), “neonatal difficulty in breastfeeding” (ICD-10: P92.5; aOR = 1.97; 95% CI: 1.27, 2.92) and “feeding problems, unspecified” (ICD-10: P92.9; aOR = 2.06; 95% CI: 1.31, 3.09). Conclusions The prevalence of alcohol use during pregnancy identified as a risk factor was comparable to previous estimates within the BCPDR. Identified prenatal alcohol exposure was associated with notable differences in maternal and neonatal characteristics and adverse neonatal outcomes. More consistent, thorough screening and prevention efforts targeting alcohol use in pregnancy are urgently needed in Canada.

Pregnancy Complications and Neonatal Outcomes in Women With Eating Disorders

2001 ◽  
Vol 158 (9) ◽  
pp. 1461-1466 ◽  
Author(s):  
Debra L. Franko ◽  
Mark A. Blais ◽  
Anne E. Becker ◽  
Sherrie Selwyn Delinsky ◽  
Dara N. Greenwood ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Pregnancy Complications ◽  
Neonatal Outcomes

Pregnancy Complications and Neonatal Outcomes in Multifetal Pregnancies Reduced to Twins Compared with Nonreduced Twin Pregnancies

1999 ◽  
Vol 16 (02) ◽  
pp. 65-71 ◽  
Author(s):  
Belgin Selam ◽  
Arda Lembet ◽  
Joanne Stone ◽  
Robert Lapinski ◽  
Richard Berkowitz
Keyword(s):  
Pregnancy Complications ◽  
Neonatal Outcomes ◽  
Twin Pregnancies

scholarly journals The Influence of Maternal Obesity on Pregnancy Complications and Neonatal Outcomes in Diabetic and Nondiabetic Women

2018 ◽  
Vol 78 (04) ◽  
pp. 400-406 ◽  
Author(s):  
Burcu Timur ◽  
Hakan Timur ◽  
Aytekin Tokmak ◽  
Hatice Isik ◽  
Elif Eyi
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Regression Analysis ◽  
Body Mass ◽  
Pregnancy Complications ◽  
Diabetic Group ◽  
Neonatal Outcomes ◽  
Control Group ◽  
Multivariable Logistic Regression Analysis ◽  
Gestational Weight

Abstract Introduction This study aimed to investigate the influence of obesity on pregnancy complications and neonatal outcomes in diabetic and nondiabetic women. Materials and Methods This retrospective case control study was conducted on 1193 pregnant women and their neonates at a tertiary level maternity hospital between March 2007 and 2011. The pregnant women were classified into 2 groups according to the presence of diabetes mellitus. Six hundred and seven patients with gestational diabetes or pregestational diabetes formed the diabetic group (study group) and 586 patients were in the nondiabetic group (control group). Demographic characteristics, body mass index, gestational weight gain, obstetric history, smoking status, type of delivery, gestational ages, pregnancy complications, neonatal outcomes were recorded for each patient. Multivariable logistic regression analysis was performed to evaluate the effect of obesity and diabetes on the pregnancy complications and neonatal outcomes. Results The mean age and pre-pregnancy body mass indices of women with diabetes mellitus were significantly higher than the control groupʼs (p < 0.001). Gestational weight gain and number of smokers were similar among the groups. Multiparity and obesity were more prevalent in the diabetic group compared to controls (both p < 0.001). Although gestational age at birth was earlier in the diabetic group, birth weights were higher in this group than in the control group (both p < 0.001). Cesarean delivery rates, the incidence of macrosomia, and neonatal intensive care unit admission rates were significantly higher in the diabetes group both with normal and increased body mass index (all p < 0.001). However, adverse pregnancy outcomes were comparable between the groups (p = 0.279). Multivariable logistic regression analysis showed that obesity is a significant risk factor for pregnancy complications (OR = 1.772 [95% CI, 1.283 – 2.449], p = 0.001) but not for adverse neonatal outcomes (OR = 1.068 [95% CI, 0.683 – 1.669], p = 0.773). Conclusion While obesity increases risk of developing a pregnancy complication, diabetes worsens neonatal outcomes.

scholarly journals Association between isolated hypothyroxinaemia in early pregnancy and perinatal outcomes

2019 ◽  
Vol 8 (4) ◽  
pp. 435-441 ◽  
Author(s):  
Xiujuan Su ◽  
Yan Zhao ◽  
Zhijuan Cao ◽  
Yingying Yang ◽  
Tony Duan ◽  
...  
Keyword(s):  
Pregnancy Complications ◽  
Placenta Previa ◽  
Perinatal Outcomes ◽  
Thyroid Stimulating Hormone ◽  
Neonatal Outcomes ◽  
Human Beings ◽  
Hypertensive Disorders Of Pregnancy ◽  
Singleton Pregnancy ◽  
Hypertensive Disorders ◽  
Increased Risk

Background The effect of isolated maternal hypothyroxinaemia (IMH) on pregnancy complications and neonatal outcomes in human beings is still controversial. Methods This was a retrospective cohort study based on the electronic medical register system. The records of women with a singleton pregnancy who sought antenatal examination between January 2014 and December 2015 at Shanghai First Maternity and Infant Hospital were extracted from the electronic medical records system. Thyroid-stimulating hormone (TSH), free thyroxine (fT4) and anti-thyroperoxidase autoantibody (TPO-Ab) was measured before 20 gestational weeks, and a multiple logistic regression model was used to estimate the odds ratios of pregnancy complications and neonatal outcomes between euthyroid women and those with isolated hypothyroxinaemia. Results A total of 8173 women were included in this study, of whom 342 (4.18%) were diagnosed with IMH. Regression analysis showed that IMH diagnosed in the second trimester (13–20 weeks) was associated with an increased risk of hypertensive disorders of pregnancy (OR = 2.66, 95% CI: 1.38–5.10) and placenta abruption (OR = 3.64, 95% CI: 1.07–12.41), but not with preterm delivery (OR = 1.09, 95% CI: 0.50–2.40), small or large gestational age of infant (OR = 0.91, 95% CI: 0.39–2.12; OR = 1.16, 95% CI: 0.72–1.86), macrosomia (OR = 1.71, 95% CI: 0.95–3.07), gestational diabetes mellitus (OR = 1.36, 95% CI: 0.86–2.15) and placenta previa (OR = 1.62, 95% CI: 0.39–7.37). Conclusion IMH could be a risk factor for hypertensive disorders of pregnancy.

scholarly journals Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis

2019 ◽  
Vol 25 (5) ◽  
pp. 593-633 ◽  
Author(s):  
Joanne Horton ◽  
Monique Sterrenburg ◽  
Simon Lane ◽  
Abha Maheshwari ◽  
Tin Chiu Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pregnancy Complications ◽  
Meta Analysis ◽  
Severe Disease ◽  
Neonatal Outcomes ◽  
Current Evidence ◽  
Ovarian Endometriosis ◽  
Reproductive Process ◽  
Oocyte Yield ◽  
Increased Risk

Abstract BACKGROUND The reproductive impact of adenomyosis and endometriosis is widely researched but the extent of these impacts remains elusive. It has been demonstrated that endometriosis, in particular, is known to result in subfertility but endometriosis and adenomyosis are increasingly linked to late pregnancy complications such as those caused by placental insufficiency. At the molecular level, the presence of ectopic endometrium perturbs the endometrial hormonal, cellular, and immunological milieu, negatively influencing decidualization, placentation, and developmental programming of the embryo. It is unclear if and how such early aberrant reproductive development relates to pregnancy outcomes in endometriosis and adenomyosis. OBJECTIVE AND RATIONALE The aims of this systematic review and meta-analysis were to (i) investigate the association of adenomyosis and endometriosis with fertility, obstetric, and neonatal outcomes of women through both assisted reproduction and natural conception and (ii) determine whether endometriosis disease subtypes have specific impacts on different stages of the reproductive process. SEARCH METHODS A systematic literature review of NHS evidence electronic databases and the Cochrane database identified all comparative and observational studies between 1980 and December 2018 in any language on adenomyosis and endometriosis with fertility, obstetric, and neonatal outcomes (23 search terms used). A total of 104 papers were selected for data extraction and meta-analysis, with use of Downs and Black standardized checklist to evaluate quality and bias. OUTCOMES We found that endometriosis consistently leads to reduced oocyte yield and a reduced fertilization rate (FR), in line with current evidence. Milder forms of endometriosis were most likely to affect the fertilization (FR OR 0.77, CI 0.63–0.93) and earlier implantation processes (implantation rate OR 0.76, CI 0.62–0.93). The more severe disease by American Society for Reproductive Medicine staging (ASRM III and IV) influenced all stages of reproduction. Ovarian endometriosis negatively affects the oocyte yield (MD −1.22, CI −1.96, −0.49) and number of mature oocytes (MD −2.24, CI −3.4, −1.09). We found an increased risk of miscarriage in both adenomyosis and endometriosis (OR 3.40, CI 1.41–8.65 and OR 1.30, CI 1.25–1.35, respectively), and endometriosis can be associated with a range of obstetric and fetal complications including preterm delivery (OR 1.38, CI 1.01–1.89), caesarean section delivery (OR 1.98 CI 1.64–2.38), and neonatal unit admission following delivery (OR 1.29, CI 1.07–1.55). WIDER IMPLICATIONS Adenomyosis and the subtypes of endometriosis may have specific complication profiles though further evidence is needed to be able to draw conclusions. Several known pregnancy complications are likely to be associated with these conditions. The complications are possibly caused by dysfunctional uterine changes leading to implantation and placentation issues and therefore could potentially have far-reaching consequences as suggested by Barker’s hypothesis. Our findings would suggest that women with these conditions should ideally receive pre-natal counselling and should be considered higher risk in pregnancy and at delivery, until evidence to the contrary is available. In order to expand our knowledge of these conditions and better advise on future management of these patients in reproductive and maternal medicine, a more unified approach to studying fertility and reproductive outcomes with longer term follow-up of the offspring and attention to the subtype of disease is necessary.

scholarly journals Assessing pregnancy and neonatal outcomes in Malawi, South Africa, Uganda, and Zimbabwe: Results from a systematic chart review

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248423
Author(s):  
Jennifer E. Balkus ◽  
Moni Neradilek ◽  
Lee Fairlie ◽  
Bonus Makanani ◽  
Nyaradzo Mgodi ◽  
...  
Keyword(s):  
South Africa ◽  
Clinical Trial ◽  
Hiv Prevention ◽  
Pregnancy Outcomes ◽  
Pregnancy Complications ◽  
Neonatal Death ◽  
Chart Review ◽  
Neonatal Outcomes ◽  
Ongoing Clinical Trial ◽  
In Pregnancy

A systematic chart review was performed to estimate the frequency of pregnancy outcomes, pregnancy complications and neonatal outcomes at facilities in Blantyre, Malawi; Johannesburg, South Africa; Kampala, Uganda; and Chitungwiza and Harare, Zimbabwe to provide comparisons with estimates from an ongoing clinical trial evaluating the safety of two biomedical HIV prevention interventions in pregnancy. A multi-site, cross-sectional chart review was conducted at Maternal Obstetric Units and hospitals where women participating in the ongoing clinical trial would be expected to deliver. All individuals delivering at the designated facilities or admitted for postpartum care within seven days of a delivery elsewhere (home, health clinic, etc.) were included in the review. Data were abstracted for pregnancy outcomes, pregnancy complications, maternal and neonatal death, and congenital anomalies. Data from 10,138 records were abstracted across all four sites (Blantyre n = 2,384; Johannesburg n = 1,888; Kampala n = 3,708; Chitungwiza and Harare n = 2,158), which included 10,426 pregnancy outcomes. The prevalence of preterm birth was 13% (range across sites: 10.4–20.7) and 4.1% of deliveries resulted in stillbirth (range: 3.1–5.5). The most commonly noted pregnancy complication was gestational hypertension, reported among 4.4% of pregnancies. Among pregnancies resulting in a live birth, 15.5% were low birthweight (range: 13.8–17.4) and 2.0% resulted in neonatal death (range:1.2–3.2). Suspected congenital anomalies were noted in 1.2% of pregnancies. This study provides systematically collected data on background rates of pregnancy outcomes, pregnancy complications and neonatal outcomes that can be used as a reference in support of ongoing HIV prevention studies. In addition, estimates from this study provide important background data for future studies of investigational products evaluated in pregnancy in these urban settings.

P–571 Preimplantation Genetic Testing for Aneuploidies (PGT-A) and pregnancy outcome

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
D Markova ◽  
R A Zaabi ◽  
N D Munck ◽  
I Elkhatib ◽  
H Fatemi ◽  
...  
Keyword(s):  
Birth Weight ◽  
Caesarean Section ◽  
Preterm Delivery ◽  
Pregnancy Complications ◽  
Neonatal Outcomes ◽  
Fetal Abnormalities ◽  
Endometrial Preparation ◽  
Group A ◽  
The Mean ◽  
Singleton Pregnancies

Abstract Study question Frozen embryo transfer (FET) of euploid blastocysts in hormone replacement therapy (HRT) or natural cycle (NC): are there differences in obstetric, fetal and neonatal outcomes? Summary answer Pregnancy complications, neonatal outcomes and fetal abnormalities are not increased after FET with PGT-A in singleton pregnancies. What is known already Since its introduction, PGT has been widely used in ART centers for preventing chromosomal and monogenic diseases. Despite its increased use, there are scarce and conflicting data about adverse pregnancy, fetal and neonatal outcomes. In one published study, the risk of preeclampsia and placenta previa was increased when PGT pregnancies were compared with non-PGT, while the incidence of gestational diabetes mellitus (GDM), preterm delivery, fetal defects and NICU (Neonatal Intensive Care Unit) admission were similar. According to other data, the rate of caesarean section in PGT pregnancies was high - around 80% in singletons. Study design, size, duration An observational, retrospective study was conducted between March 2015 and November 2019 in patients with singleton pregnancies after ART with PGT-A/FET/HRT and NC. A total number of 353 patients from two fertility centers (ART Fertility Clinics Dubai and Abu Dhabi, UAE), were included. They were divided into two groups according to the endometrial preparation for FET: group A: HRT (n = 225) and group B: NC (n = 128). Participants/materials, setting, methods Patients with primary / secondary infertility and at least one transferable euploid blastocyst after trophectoderm biopsy, achieving an ongoing singleton pregnancy after FET were included. Endometrial preparation for FET was either performed in a NC or an HRT cycle. For this study, the following pregnancy outcomes were recorded: GDM, preeclampsia and hypertension, obstetric cholestasis, placental abnormalities, mode of delivery, preterm delivery, gestational age at delivery, birth weight, fetal abnormalities and admission to NICU. Main results and the role of chance There were no statistically significant differences in maternal and demographic characteristics of the studied groups. The mean maternal age was 34.05(20–45) and 34.26(23–47) years for group A and B respectively. The mean BMI was 28.31kg/m² (17.93–43.76) versus 27.93 (17.32–43.18). The ratio of nulliparous versus multiparous patients was 1:1 for both groups. Majority of the patients in both groups were of Arab ethnicity. The number of patients recorded as smokers was low and comparable in the groups. The mean gestational age at the time of delivery was comparable: 37.64 gestational weeks (24–41) versus 37.76 (26–41). The Caesarean section rate was around 50% for both groups. The rate of preterm delivery was comparable in both groups (16.9% and 18.8% for group A and B respectively). There was no detectable difference in the distribution of the birth weight in both groups with a median weight of 3000 grams of which 13.6% were low birth weight. In the studied groups, 30.5% had pregnancy complications with no observed statistically significant differences when the groups were compared. There was no increased incidence of fetal abnormalities. Admission to NICU was comparable and was related to prematurity. Limitations, reasons for caution The limitations of the study are the retrospective design and the small number of participants. Wider implications of the findings: In patients with FET of an euploid embryo after PGT-A, the type of FET treatment preparation (HRT or NC) has no significant effect on pregnancy complications, birth weight and fetal abnormalities. The findings of the present study could be used to improve prenatal counselling for women undergoing ART with PGT-A. Trial registration number Not applicable

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