A Novel Pharmacologic Treatment for Bipolar Disorder

2010 ◽  
Author(s):  
Brian P. Brennan
Keyword(s):  
Bipolar Disorder ◽  
Pharmacologic Treatment

Outcome in the Pharmacologic Treatment of Bipolar Disorder

1996 ◽  
Vol 16 (SUPPLEMENT 1) ◽  
pp. 15S-23S ◽  
Author(s):  
PAUL E. KECK ◽  
SUSAN L. McELROY
Keyword(s):  
Bipolar Disorder ◽  
Pharmacologic Treatment

Pharmacologic Treatment of Bipolar Disorder Through the Life Cycle

1996 ◽  
Vol 9 (2) ◽  
pp. 95-103
Author(s):  
Cherry Wyant Jackson
Keyword(s):  
Bipolar Disorder ◽  
Life Cycle ◽  
Pharmacologic Treatment ◽  
Rapid Cycling ◽  
Multiple Relapses

Bipolar disorder is a long-term illness associated with multiple relapses and recurrences throughout the life cycle. Lithium, carbamazepine, and valproate are the mainstays of treatment for this illness. Each of these agents will be reviewed as well as alternatives for patients who fail treatment with lithium, have manic agitation, psychosis, depression, rapid cycling, and mixed mania. Compliance issues will also be dis cussed. Copyright © 1996 by W.B. Saunders Company

scholarly journals Commentary: 20-Year Trends in the Pharmacologic Treatment of Bipolar Disorder by Psychiatrists in Outpatient Care Settings

2021 ◽  
Vol 11 ◽  
Author(s):  
Bruno Etain ◽  
Emilie Olie ◽  
Philippe Courtet ◽  
Ophelia Godin ◽  
Marion Leboyer
Keyword(s):  
Bipolar Disorder ◽  
Outpatient Care ◽  
Pharmacologic Treatment

scholarly journals Individual level prediction of emerging suicide events in the pharmacologic treatment of bipolar disorder

2021 ◽  
Author(s):  
Sean X. Luo ◽  
Adam Ciarleglio ◽  
Hanga Galfalvy ◽  
Michael Grunebaum ◽  
Leo Sher ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Variable Selection ◽  
Suicidal Behavior ◽  
Predictive Models ◽  
Suicide Attempts ◽  
Bipolar Depression ◽  
Depression Scale ◽  
Hamilton Depression Scale ◽  
Pharmacologic Treatment ◽  
Survival Trees

AbstractBackgroundPatients with bipolar disorder have a high lifetime risk of suicide. Predicting, preventing and managing suicidal behavior are major goals in clinical practice. Changes in suicidal thoughts and behavior are common in the course of treatment of bipolar disorder.MethodsUsing a dataset from a randomized clinical trial of bipolar disorder treatment (N=98), we tested predictors of future suicidal behavior identified through a review of literature and applied marginal variable selection and machine learning methods. The performance of the models was assessed using the optimism-adjusted C statistic.ResultsNumber of prior hospitalizations, number of prior suicide attempts, current employment status and Hamilton Depression Scale were identified as predictors and a simple logistic regression model was constructed. This model was compared with a model incorporating interactions with treatment group assignment, and more complex variable selection methods (LASSO and Survival Trees). The best performing models had average optimism-adjusted C-statistics of 0.67 (main effects only) and 0.69 (Survival Trees). Incorporating medication group did not improve prediction performance of the models.ConclusionsThese results suggest that models with a few predictors may yield a clinically meaningful way to stratify risk of emerging suicide events in patients who are undergoing pharmacologic treatment for bipolar disorder.Significance StatementThis study aims to find out whether suicide events that occur during the pharmacological treatment of bipolar disorder, a severe psychiatric disorder that is highly associated with suicide behavior, can be predicted. Using existing methods, we developed and compared several predictive models. We showed that these models performed similarly to predictive models of other outcomes, such as treatment efficacy, in unipolar and bipolar depression. This suggests that suicide events during bipolar disorder may be a feasible target for individualized interventions in the future.

Pharmacologic Treatment of Pediatric Bipolar Disorder

2009 ◽  
Vol 18 (2) ◽  
pp. 455-469 ◽  
Author(s):  
Jayasree J. Nandagopal ◽  
Melissa P. DelBello ◽  
Robert Kowatch
Keyword(s):  
Bipolar Disorder ◽  
Pediatric Bipolar Disorder ◽  
Pharmacologic Treatment
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