The peptide drugs, compensation of disturbed cognitive functions, inter-hemisphere asymmetry and their possible neurochemical mechanisms in the ascending row of the mammals

2013 ◽  
Author(s):  
T. N. Sollertinskaja ◽  
M. V. Shorokhov
Keyword(s):  
Cognitive Functions ◽  
Peptide Drugs ◽  
Neurochemical Mechanisms ◽  
Hemisphere Asymmetry

Language processing is not a race against time

2016 ◽  
Vol 39 ◽  
Author(s):  
Giosuè Baggio ◽  
Carmelo M. Vicario
Keyword(s):  
Information Processing ◽  
Human Brain ◽  
Language Processing ◽  
Cognitive Functions ◽  
Memory Systems ◽  
Language System ◽  
Moderating Factors

AbstractWe agree with Christiansen & Chater (C&C) that language processing and acquisition are tightly constrained by the limits of sensory and memory systems. However, the human brain supports a range of cognitive functions that mitigate the effects of information processing bottlenecks. The language system is partly organised around these moderating factors, not just around restrictions on storage and computation.

Malfunctional Reorganization in the Developing Limbo-Prefrontal System in Animals: Implications for Human Psychoses?

2001 ◽  
Vol 12 (1) ◽  
pp. 8-14
Author(s):  
Gertraud Teuchert-Noodt ◽  
Ralf R. Dawirs
Keyword(s):  
Prefrontal Cortex ◽  
Mental Disorders ◽  
Dentate Gyrus ◽  
Cognitive Functions ◽  
Experimental Approach ◽  
Regulatory Mechanisms ◽  
Hippocampal Dentate Gyrus ◽  
Non Invasive ◽  
Invasive Method ◽  
Activity Dependent

Abstract: Neuroplasticity research in connection with mental disorders has recently bridged the gap between basic neurobiology and applied neuropsychology. A non-invasive method in the gerbil (Meriones unguiculus) - the restricted versus enriched breading and the systemically applied single methamphetamine dose - offers an experimental approach to investigate psychoses. Acts of intervening affirm an activity dependent malfunctional reorganization in the prefrontal cortex and in the hippocampal dentate gyrus and reveal the dopamine position as being critical for the disruption of interactions between the areas concerned. From the extent of plasticity effects the probability and risk of psycho-cognitive development may be derived. Advance may be expected from insights into regulatory mechanisms of neurogenesis in the hippocampal dentate gyrus which is obviously to meet the necessary requirements to promote psycho-cognitive functions/malfunctions via the limbo-prefrontal circuit.

Linguistische Fairness und differentielle Validität des Auditiven Wortlisten Lerntests (AWLT) bei Demenz vom Alzheimer-Typ

Diagnostica ◽  
2019 ◽  
Vol 65 (4) ◽  
pp. 193-204
Author(s):  
Johannes Baltasar Hessler ◽  
David Brieber ◽  
Johanna Egle ◽  
Georg Mandler ◽  
Thomas Jahn
Keyword(s):  
Cognitive Functions ◽  
Kognitive Funktionen ◽  
Alzheimer Demenz ◽  
Test Sets

Zusammenfassung. Der Auditive Wortlisten Lerntest (AWLT) ist Teil des Test-Sets Kognitive Funktionen Demenz (CFD; Cognitive Functions Dementia) im Rahmen des Wiener Testsystems (WTS). Der AWLT wurde entlang neurolinguistischer Kriterien entwickelt, um Interaktionen zwischen dem kognitiven Status der Testpersonen und den linguistischen Eigenschaften der Lernliste zu reduzieren. Anhand einer nach Alter, Bildung und Geschlecht parallelisierten Stichprobe von gesunden Probandinnen und Probanden ( N = 44) und Patientinnen und Patienten mit Alzheimer Demenz ( N = 44) wurde mit ANOVAs für Messwiederholungen überprüft, inwieweit dieses Konstruktionsziel erreicht wurde. Weiter wurde die Fähigkeit der Hauptvariablen des AWLT untersucht, zwischen diesen Gruppen zu unterscheiden. Es traten Interaktionen mit geringer Effektstärke zwischen linguistischen Eigenschaften und der Diagnose auf. Die Hauptvariablen trennten mit großen Effektstärken Patientinnen und Patienten von Gesunden. Der AWLT scheint bei vergleichbarer differenzieller Validität linguistisch fairer als ähnliche Instrumente zu sein.

Caffeine and Placebo Expectation

2007 ◽  
Vol 21 (2) ◽  
pp. 91-99 ◽  
Author(s):  
Yunfeng Sun ◽  
Yinling Zhang ◽  
Ning He ◽  
Xufeng Liu ◽  
Danmin Miao
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Cognitive Functions ◽  
Cardiovascular Regulation ◽  
Double Blind ◽  
Positive Effects ◽  
Pressure Tests ◽  
Healthy Males

Abstract. Caffeine placebo expectation seems to improve vigilance and cognitive performance. This study investigated the effect of caffeine and placebo expectation on vigilance and cognitive performance during 28 h sleep deprivation. Ten healthy males volunteered to take part in the double-blind, cross-over study, which required participants to complete five treatment periods of 28 h separated by 1-week wash-out intervals. The treatments were no substance (Control); caffeine 200 mg at 00:00 (C200); placebo 200 mg at 00:00 (P200); twice caffeine 200 mg at 00:00 and 04:00 (C200-C200); caffeine 200 mg at 00:00 and placebo 200 mg at 04:00 (C200-P200). Participants were told that all capsules were caffeine and given information about the effects of caffeine to increase expectation. Vigilance was assessed by a three-letter cancellation test, cognitive functions by the continuous addition test and Stroop test, and cardiovascular regulation by heart rate and blood pressure. Tests were performed bihourly from 00:00 to 10:00 of the second day. Results indicated that C200-P200 and C200-C200 were more alert (p < .05) than Control and P200. Their cognitive functions were higher (p < .05) than Control and P200. Also, C200-P200 scored higher than C200 in the letter cancellation task (p < .05). No test showed any significant differences between C200-P200 and C200-C200. The results demonstrated that the combination of caffeine 200 mg and placebo 200 mg expectation exerted prolonged positive effects on vigilance and cognitive performance.

Moving to Solution

2013 ◽  
Vol 60 (6) ◽  
pp. 403-409 ◽  
Author(s):  
K. Werner ◽  
M. Raab
Keyword(s):  
Problem Solving ◽  
Embodied Cognition ◽  
Cognitive Functions ◽  
Problem Space ◽  
Arm Swing ◽  
String Problem ◽  
Problem Solving Process ◽  
Problem Solving Task ◽  
Bodily Movements

Embodied cognition theories suggest a link between bodily movements and cognitive functions. Given such a link, it is assumed that movement influences the two main stages of problem solving: creating a problem space and creating solutions. This study explores how specific the link between bodily movements and the problem-solving process is. Seventy-two participants were tested with variations of the two-string problem (Experiment 1) and the water-jar problem (Experiment 2), allowing for two possible solutions. In Experiment 1 participants were primed with arm-swing movements (swing group) and step movements on a chair (step group). In Experiment 2 participants sat in front of three jars with glass marbles and had to sort these marbles from the outer jars to the middle one (plus group) or vice versa (minus group). Results showed more swing-like solutions in the swing group and more step-like solutions in the step group, and more addition solutions in the plus group and more subtraction solutions in the minus group. This specificity of the connection between movement and problem-solving task will allow further experiments to investigate how bodily movements influence the stages of problem solving.

Prospective Examination of the Effects of an Amateur Boxing Tournament on Acute Cognitive Functions

2004 ◽  
Author(s):  
J. Moriarity ◽  
A. Collie ◽  
J. Buchanan ◽  
P. Leary ◽  
M. McStephen ◽  
...  
Keyword(s):  
Cognitive Functions ◽  
Amateur Boxing

Conformationally Constrained Peptide Drugs Targeted at the Blood-Brain Barrier

1995 ◽  
Author(s):  
Thomas P. Davis ◽  
Thomas J. Abbruscato ◽  
Elizabeth Brownson ◽  
Victor J. Hruby
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Peptide Drugs ◽  
Conformationally Constrained ◽  
Blood Brain
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