Human umbilical cord blood derived neural stem cells transplanted into the brain of focal cerebral ischemic rats provide trophic support for endogenous neurogenesis

2013 ◽  
Author(s):  
B. Lukomska ◽  
A. Jablonska ◽  
K. Drela ◽  
L. Wojcik-Stanaszek ◽  
T. Zalewska
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Trophic Support ◽  
Cerebral Ischemic ◽  
The Brain

Neurogenic reserve in adults rats potentially stimulated by transplantation of neural stem cells derived from human umbilical cord blood (HUCB-NSC)

2009 ◽  
Vol 61 (6) ◽  
pp. 1244
Author(s):  
Jabłońska Anna ◽  
Kozłowska Hanna ◽  
Krajewska Dorota ◽  
Wanacka Elżbieta ◽  
Domańska-Janik Krystyna ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord

scholarly journals Cellular Environment Directs Differentiation of Human Umbilical Cord Blood–Derived Neural Stem Cells In Vitro

2011 ◽  
Vol 59 (3) ◽  
pp. 289-301 ◽  
Author(s):  
Inga Markiewicz ◽  
Joanna Sypecka ◽  
Krystyna Domanska-Janik ◽  
Tomasz Wyszomirski ◽  
Barbara Lukomska
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Cellular Environment

scholarly journals Direct Conversion of Human Umbilical Cord Blood into Induced Neural Stem Cells with SOX2 and HMGA2

2017 ◽  
Vol 10 (2) ◽  
pp. 227-234 ◽  
Author(s):  
Jae-Jun Kim ◽  
Ji-Hee Shin ◽  
Kyung-Rok Yu ◽  
Byung-Chul Lee ◽  
Insung Kang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Direct Conversion ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Induced Neural Stem Cells

Hoechst dye efflux reveals a novel CD7+CD34− lymphoid progenitor in human umbilical cord blood

Blood ◽  
2000 ◽  
Vol 96 (6) ◽  
pp. 2125-2133 ◽  
Author(s):  
Robert W. Storms ◽  
Margaret A. Goodell ◽  
Alan Fisher ◽  
Richard C. Mulligan ◽  
Clay Smith
Keyword(s):  
Stem Cells ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Large Population ◽  
Lymphoid Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Hematopoietic Stem ◽  
Cd34 Cells

Abstract A novel Hoechst 33342 dye efflux assay was recently developed that identifies a population of hematopoietic cells termed side population (SP) cells. In the bone marrow of multiple species, including mice and primates, the SP is composed primarily of CD34−cells, yet has many of the functional properties of hematopoietic stem cells (HSCs). This report characterizes SP cells from human umbilical cord blood (UCB). The SP in unfractionated UCB was enriched for CD34+ cells but also contained a large population of CD34− cells, many of which were mature lymphocytes. SP cells isolated from UCB that had been depleted of lineage-committed cells (Lin− UCB) contained CD34+ and CD34− cells in approximately equivalent proportions. Similar to previous descriptions of human HSCs, the CD34+Lin− SP cells were CD38dimHLA-DRdimThy-1dimCD45RA−CD71−and were enriched for myelo-erythroid precursors. In contrast, the CD34−Lin− SP cells were CD38−HLA-DR−Thy-1−CD71−and failed to generate myelo-erythroid progeny in vitro. The majority of these cells were CD7+CD11b+CD45RA+, as might be expected of early lymphoid cells, but did not express other lymphoid markers. The CD7+CD34−Lin− UCB SP cells did not proliferate in simple suspension cultures but did differentiate into natural killer cells when cultured on stroma with various cytokines. In conclusion, the human Lin− UCB SP contains both CD34+ multipotential stem cells and a novel CD7+CD34−Lin− lymphoid progenitor. This observation adds to the growing body of evidence that CD34− progenitors exist in humans.

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