Cumulative Risks Versus Repeated Victimization: Predictors of Adolescent Adjustment

2012 ◽  
Author(s):  
Kathryn Reid-Quinones ◽  
Wendy Kliewer
Keyword(s):  
Adolescent Adjustment ◽  
Cumulative Risks

scholarly journals A Perspective of the Cumulative Risks from Climate Change on Mt. Everest: Findings from the 2019 Expedition

2021 ◽  
Vol 18 (4) ◽  
pp. 1928
Author(s):  
Kimberley R. Miner ◽  
Paul Andrew Mayewski ◽  
Mary Hubbard ◽  
Kenny Broad ◽  
Heather Clifford ◽  
...  
Keyword(s):  
Climate Change ◽  
Water Pollution ◽  
Scientific Data ◽  
Human Waste ◽  
National Geographic ◽  
Glacier Melt ◽  
Cumulative Risks

In 2019, the National Geographic and Rolex Perpetual Planet Everest expedition successfully retrieved the greatest diversity of scientific data ever from the mountain. The confluence of geologic, hydrologic, chemical and microbial hazards emergent as climate change increases glacier melt is significant. We review the findings of increased opportunity for landslides, water pollution, human waste contamination and earthquake events. Further monitoring and policy are needed to ensure the safety of residents, future climbers, and trekkers in the Mt. Everest watershed.

scholarly journals Age Conditional Probability of Ocular and Ocular Adnexal Malignancies

2020 ◽  
pp. 1-4
Author(s):  
Mathias Nittmann ◽  
Curtis E. Margo
Keyword(s):  
Conditional Probability ◽  
Uveal Melanoma ◽  
Incidence Rates ◽  
Cross Sectional ◽  
Pedagogical Tool ◽  
United States Population ◽  
Age Dependent ◽  
Cumulative Risks ◽  
Adjusted Incidence ◽  
Communicating Risk

<b><i>Aim:</i></b> The aim of this study was to discuss and illustrate the role age-conditional probability has in communicating risk of developing ocular and ocular adnexal malignancies. <b><i>Methods:</i></b> Cross-sectional incidence for retinoblastoma, uveal melanoma, conjunctival melanoma, and lacrimal gland carcinomas from 2000 to 2017 were obtained from the Surveillance, Epidemiology and End Results (SEER) database. Incidence rates were age-adjusted to the 2000 United States population. Age-adjusted incidence was converted to age-interval and cumulative risks. Outcomes were examined in 20-year intervals and cumulatively for adult cancers and yearly for retinoblastoma. <b><i>Results:</i></b> The risk of each malignancy displayed age-dependent variation. For adult malignancies, men were at higher risk at most age intervals. Uveal melanoma had the greatest cumulative lifetime risk. The probability of developing retinoblastoma declines precipitously after age 3 years. <b><i>Conclusions:</i></b> Age-conditional probability of developing cancer is a conceptually friendly means of understanding and communicating risk. It is particularly useful in comparing the risks of uncommon or rare cancers, such as those found in and around the eye. The assessment of risk in terms of age-conditional probability is a versatile and an underutilized pedagogical tool.

scholarly journals Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Abram Bunya Kamiza ◽  
Wen-Chang Wang ◽  
Jeng-Fu You ◽  
Reiping Tang ◽  
Huei-Tzu Chien ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lynch Syndrome ◽  
Cumulative Risk ◽  
Germline Mutations ◽  
Han Chinese ◽  
Chinese Patients ◽  
Mutation Carriers ◽  
Amsterdam Criteria ◽  
Cumulative Risks ◽  
Age And Sex

AbstractPatients with Lynch syndrome have a high risk of colorectal cancer (CRC). In this study, we estimated the age- and sex-specific cumulative risks of CRC in Han Chinese patients with Lynch syndrome caused by the pathogenic germline mutations in MLH1 or MSH2 in Taiwan. Based on 321 mutation carriers and 419 non-mutation carriers from 75 pedigrees collected in an Amsterdam criteria family registry in Taiwan, the age- and sex-specific cumulative risks of CRC in male carriers of mutation in MLH1 and MSH2 at the age of 70 years were 60.3% (95% confidence interval (CI) = 31.1%–89.9%) and 76.7% (95% CI = 37.2%–99.0%), respectively. For females, the cumulative risks of CRC at the age of 70 were estimated to be 30.6% (95% CI = 14.3%–57.7%) and 49.3% (95% CI = 21.9%–84.5%) in the carriers of MLH1 and MSH2 germline mutations, respectively. In conclusion, the cumulative risks of CRC at the age of 70 in the Han Chinese patients is higher in mutation carriers than non-mutation carriers and male mutation carriers have a higher cumulative risk of developing CRC than the female mutation carriers.

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