The impact of having a very low birthweight baby

1994 ◽  
Author(s):  
Keyword(s):  
Low Birthweight ◽  
Very Low Birthweight ◽  
The Impact

scholarly journals Safety of Cow’s Milk-Derived Fortifiers Used with an All-Human Milk Base Diet in Very Low Birthweight Preterm Infants

2020 ◽  
Vol 15 (7) ◽  
pp. 3-13
Author(s):  
Alan Lucas ◽  
Maushumi Assad ◽  
Jan Sherman ◽  
John Boscardin ◽  
Steven Abrams
Keyword(s):  
Human Milk ◽  
Preterm Infants ◽  
Low Birthweight ◽  
Ductus Arteriosus ◽  
Cow’S Milk ◽  
Very Low Birthweight ◽  
Cow's Milk ◽  
Increased Risk ◽  
Preterm Formula ◽  
The Impact

Background: Very low birthweight (VLBW) preterm infants fed mothers own milk (MOM) need nutritional supplementation, traditionally achieved with cow’s milk derived fortifier (CMDF) and preterm formula (PTF) if MOM is insufficient. CM products have been associated with diverse major morbidities. The current recommendation is to preferentially replace PTF with donor milk (DM) to produce a 100% human milk (HM) base diet, usually fortified with CMDF. Objective: To identify whether CMDF, even when fed with a 100% HM base diet, is related to an increased risk of major morbidities. Methods: We identified a randomized trial with an all-HM base diet, comparing CMDF with a fortifier derived from human milk (HMDF), and two additional studies of this design were generated from raw data as subgroup analyses of a randomized controlled trial and a quasi-experimental study. Using these studies, we calculated the impact of CMDF on major morbidities of death, necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), sepsis, bronchopulmonary dysplasia (BPD) and patent ductus arteriosus (PDA). Results: Each study individually provided support for an increase in major morbidities with CMDF. Meta-analyses of pooled data showed that compared to HMDF, the CMDF group had large in- creases in NEC (RR = 3.3; P = .001), ROP (RR = 2.2; P = .007), PDA (RR = 1.6; P = .009), interruption of feeding (RR = 3.4; P = .001) and a positive mortality/morbidity index based on one or more of death, NEC, sepsis, ROP and BPD (RR = 1.4; P = .006). Conclusions: Despite the increased use of HM in modern neonatal care as a base diet, we found a greater risk of critical morbidities with CMDF compared with HMDF. This burden of morbidity provides evidence that the benefits of an HM base diet, might be, in part, counteracted by multiple adverse outcomes relating to the use of CMDF.

Prevalence and Infant Mortality of Major Congenital Malformations Stratified by Birthweight

Neonatology ◽  
2021 ◽  
pp. 1-19
Author(s):  
Janine Kröger ◽  
Christian Günster ◽  
Günther Heller ◽  
Elke Jeschke ◽  
Jürgen Malzahn ◽  
...  
Keyword(s):  
Infant Mortality ◽  
Congenital Malformations ◽  
Low Birthweight ◽  
Survival Rates ◽  
Very Low Birthweight ◽  
Life Threatening ◽  
Major Congenital Malformations ◽  
Public Health Insurance System ◽  
Severe Congenital Heart Disease ◽  
The Impact

<b><i>Background:</i></b> Low birthweight and major congenital malformations (MCMs) are key causes of infant mortality. <b><i>Objectives:</i></b> The aim of this study was to explore the prevalence of MCMs in infants with low and very low birthweight and analyze the impact of MCMs and birthweight on infant mortality. <b><i>Methods:</i></b> We determined prevalence and infant mortality of 28 life-threatening MCMs in very-low-birthweight (&#x3c;1,500 g, VLBW), low-birthweight (1,500–2,499 g, LBW), or normal-birthweight (≥2,500 g, NBW) infants in a cohort of 2,727,002 infants born in Germany in 2006–2017, using de-identified administrative data of the largest statutory public health insurance system in Germany. <b><i>Results:</i></b> The rates of VLBW, LBW, and NBW infants studied were 1.3% (34,401), 4.0% (109,558), and 94.7% (2,583,043). MCMs affected 0.5% (13,563) infants, of whom &#x3e;75% (10,316) had severe congenital heart disease. The prevalence (per 10,000) of any/cardiac MCM was increased in VLBW (286/176) and LBW (244/143), as compared to NBW infants (38/32). Infant mortality rates were significantly higher in infants with an MCM, as opposed to infants without an MCM, in each birthweight group (VLBW 28.5% vs. 11.5%, LBW 16.7% vs. 0.9%, and NBW 8.6% vs. 0.1%). For most MCMs, observed survival rates in VLBW and LBW infants were lower than expected, as calculated from survival rates of VLBW or LBW infants without an MCM, and NBW infants with an MCM. <b><i>Conclusions:</i></b> Infants with an MCM are more often born with LBW or VLBW, as opposed to infants without an MCM. Many MCMs carry significant excess mortality when occurring in VLBW or LBW infants.

The Impact of Neonatal Care Resources on Regional Variation in Neonatal Mortality Among Very Low Birthweight Infants in Korea

2013 ◽  
Vol 27 (2) ◽  
pp. 216-225 ◽  
Author(s):  
Jae Won Shim ◽  
Myo Jing Kim ◽  
Ee-Kyung Kim ◽  
Hyun Kyung Park ◽  
Eun Song Song ◽  
...  
Keyword(s):  
Neonatal Mortality ◽  
Regional Variation ◽  
Low Birthweight ◽  
Neonatal Care ◽  
Very Low Birthweight ◽  
Very Low Birthweight Infants ◽  
The Impact

Universal Face Masking Reduces Respiratory Viral Infections Among Inpatient Very-Low-Birthweight Neonatal Infants

2020 ◽  
Vol 71 (11) ◽  
pp. 2958-2961 ◽  
Author(s):  
Wing Yee Tong ◽  
Chee Fu Yung ◽  
Lee Chern Chiew ◽  
Siong Beng Chew ◽  
Li Duan Ang ◽  
...  
Keyword(s):  
Low Birthweight ◽  
Viral Infections ◽  
Very Low Birthweight ◽  
Very Low Birthweight Infants ◽  
Respiratory Viral Infections ◽  
Step Down ◽  
Syncytial Virus ◽  
The Impact ◽  
Level 2 ◽  
Neonatal Infants

Abstract We reviewed the impact of a universal face masking policy on respiratory viral infections (RVIs) among admitted very-low-birthweight infants in our neonatal department. There was a significant decrease in RVI incidence, specifically in our step-down level 2 unit, with respiratory syncytial virus and parainfluenza virus being the most common viruses isolated.

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