Memory for pairs of faces: An associative memory impairment?

2006 ◽  
Author(s):  
Matthew G. Rhodes ◽  
Alan D. Castel ◽  
Larry L. Jacoby
2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Nick Corriveau‐Lecavalier ◽  
Natasha Rajah ◽  
Samira Mellah ◽  
Sylvie Belleville ◽  

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Daniela Puzzo ◽  
Roberto Piacentini ◽  
Mauro Fá ◽  
Walter Gulisano ◽  
Domenica D Li Puma ◽  
...  

The concurrent application of subtoxic doses of soluble oligomeric forms of human amyloid-beta (oAβ) and Tau (oTau) proteins impairs memory and its electrophysiological surrogate long-term potentiation (LTP), effects that may be mediated by intra-neuronal oligomers uptake. Intrigued by these findings, we investigated whether oAβ and oTau share a common mechanism when they impair memory and LTP in mice. We found that as already shown for oAβ, also oTau can bind to amyloid precursor protein (APP). Moreover, efficient intra-neuronal uptake of oAβ and oTau requires expression of APP. Finally, the toxic effect of both extracellular oAβ and oTau on memory and LTP is dependent upon APP since APP-KO mice were resistant to oAβ- and oTau-induced defects in spatial/associative memory and LTP. Thus, APP might serve as a common therapeutic target against Alzheimer's Disease (AD) and a host of other neurodegenerative diseases characterized by abnormal levels of Aβ and/or Tau.


2013 ◽  
Vol 209 (3) ◽  
pp. 479-484 ◽  
Author(s):  
Jonathan Guez ◽  
Jonathan Cohen ◽  
Moshe Naveh-Benjamin ◽  
Asher Shiber ◽  
Yan Yankovsky ◽  
...  

2012 ◽  
Vol 13 (1) ◽  
pp. 103 ◽  
Author(s):  
Shawn N Watson ◽  
Tara E Risling ◽  
Petra M Hermann ◽  
Willem C Wildering

2007 ◽  
Vol 150 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Christopher G. AhnAllen ◽  
Paul G. Nestor ◽  
Robert W. McCarley ◽  
Martha E. Shenton

2020 ◽  
Vol 17 (1) ◽  
pp. 1-18
Author(s):  
Melissa Adler

Studies show that emotion enhances memory for individual items but weakens memory for associations between items (Bisby & Burgess, 2014). One explanation for this associative memory impairment is that emotional stimuli capture attention, causing enhanced encoding of the emotional item but reduced encoding of the surrounding environment (Schupp, Junghöfer, Weike, & Hamm, 2003). This explanation generates the prediction that emotional information always impairs associative memory. Alternatively, it may be that emotion orients attention towards threats in the environment, suggesting that emotions’ effects on associative memory may differ depending on where they indicate a threat may be coming from (Öhman, Flykt, & Esteves, 2001). For example, seeing an angry face constitutes a direct threat. The angry face itself potentially captures attention and thereby reduces memory for its associated information. In contrast, seeing a fearful face indicates a threat elsewhere in the environment. Therefore, the fearful face may redirect attention towards the surroundings and thus enhance encoding of the associated information. To adjudicate between these hypotheses, subjects studied sets of three images, consisting of two objects and a face with either a neutral, angry, or fearful expression. Subjects were later tested on their memory for the associations between the three items. Supporting the first hypothesis, memory for both angry and fearful associations was worse than memory for neutral associations. Contrary to the second hypothesis, there were no differences in memory for angry versus fearful associations. Thus, emotional information itself seems to capture attention, weakening memory for related information.


1989 ◽  
Vol 34 (1) ◽  
pp. 69-70
Author(s):  
Marion Perlmutter
Keyword(s):  

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