The role of recollection in high-confidence know judgments

2010 ◽  
Author(s):  
Laura Mickes ◽  
Vivian Hwe ◽  
John T. Wixted
Keyword(s):  
High Confidence

scholarly journals Standard Quality Banking Services of Islamic Banks

2018 ◽  
Vol 8 (1) ◽  
pp. 301
Author(s):  
Haneen A. Al-Khawaja ◽  
Barjoyai Bardai
Keyword(s):  
Islamic Law ◽  
Theoretical Aspect ◽  
Islamic Banking ◽  
Islamic Banks ◽  
High Confidence ◽  
Banking Services ◽  
Standard Quality ◽  
Definition Of

This research discusses in detail the theoretical aspect of the quality standards of banking services of traditional Islamic banks. The criterion of "Shari'ah Compliance" was added by the researcher to the importance and role of dealing with Islamic banks, the definition of this standard and its importance, how to test it for banks as well as how, without the legitimate commitment of these banks to what is classified as Islamic from the foundation, we focus on the importance of the existence of a legal commitment to any Islamic bank to achieve the quality of Islamic banking services of high quality in accordance with Islamic law and laws to achieve a high confidence in the customers who belong to him and deal with his Conspiracy.

Adaptive Software based on Correct-by-Construction Metamodels

2013 ◽  
pp. 308-325 ◽  
Author(s):  
Franck Barbier ◽  
Pierre Castéran ◽  
Eric Cariou ◽  
Olivier le Goaer
Keyword(s):  
Modeling Language ◽  
Formal Proofs ◽  
High Confidence ◽  
The Core ◽  
Significant Research ◽  
The Status ◽  
Meta Modeling ◽  
Computing Environments ◽  
Inductive Types

Despite significant research efforts in the last decade, UML has not reached the status of being a high-confidence modeling language. This is due to unsound foundations that result from the insufficiently formal structuring of metamodels that define the MOF/UML Infrastructure. Nowadays, UML-related metamodels are implemented in computing environments (e.g., EMF) to play the role of metadata when one seeks adaptation at runtime. To properly instrument metamodel-based adaptation, this chapter re-formalizes the core of the MOF/UML Infrastructure along with giving formal proofs that avoid ambiguities, contradictions, or redundancies. A (meta-)class creation mechanism (either by instantiation or inheritance) is based on inductive types taken from the constructive logic. Inherent proofs based on the Coq automated prover are also provided. This chapter’s contribution is aligned with a previously established metamodeling framework named “Matters of (meta-)modeling.”

scholarly journals Primary Care Provider Involvement in Thyroid Cancer Survivorship Care

2020 ◽  
Vol 105 (9) ◽  
pp. e3300-e3306 ◽  
Author(s):  
Archana Radhakrishnan ◽  
David Reyes-Gastelum ◽  
Brittany Gay ◽  
Sarah T Hawley ◽  
Ann S Hamilton ◽  
...  
Keyword(s):  
Primary Care ◽  
Thyroid Cancer ◽  
Cancer Survivorship ◽  
Primary Care Providers ◽  
Survivorship Care ◽  
Care Providers ◽  
High Confidence ◽  
Neck Ultrasound

Abstract Context While prior research has examined how primary care providers (PCPs) can care for breast and colon cancer survivors, little is known about their role in thyroid cancer survivorship. Objective To understand PCP involvement and confidence in thyroid cancer survivorship care. Design/Setting/Participants We surveyed PCPs identified by thyroid cancer patients from the Georgia and LA SEER registries (n = 162, response rate 56%). PCPs reported their involvement in long-term surveillance and confidence in handling survivorship care (role of random thyroglobulin levels and neck ultrasound, and when to end long-term surveillance and refer back to the specialist). We examined: 1) PCP-reported factors associated with involvement using multivariable analyses; and 2) bivariate associations between involvement and confidence in handling survivorship care. Main Outcome Measures PCP involvement (involved vs not involved) and confidence (high vs low). Results Many PCPs (76%) reported being involved in long-term surveillance. Involvement was greater among PCPs who noted clinical guidelines as the most influential source in guiding treatment (OR 4.29; 95% CI, 1.56-11.82). PCPs reporting high confidence in handling survivorship varied by aspects of care: refer patient to specialist (39%), role of neck ultrasound (36%) and random thyroglobulin levels (27%), and end long-term surveillance (14%). PCPs reporting involvement were more likely to report high confidence in discussing the role of random thyroglobulin levels (33.3% vs 7.9% not involved; P < 0.01). Conclusions While PCPs reported being involved in long-term surveillance, gaps remain in their confidence in handling survivorship care. Thyroid cancer survivorship guidelines that delineate PCP roles present one opportunity to increase confidence about their participation.

scholarly journals The Capture of a Disabled Proteasome Identifies Erg25 as a Substrate for Endoplasmic Reticulum Associated Degradation

2020 ◽  
Vol 19 (11) ◽  
pp. 1896-1909
Author(s):  
Teresa M. Buck ◽  
Xuemei Zeng ◽  
Pamela S. Cantrell ◽  
Richard T. Cattley ◽  
Zikri Hasanbasri ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Ubiquitin Proteasome System ◽  
Sterol Synthesis ◽  
High Confidence ◽  
Assembly Pathway ◽  
Affinity Isolation ◽  
Proteasome Subunits ◽  
Ubiquitin Proteasome ◽  
Erad Pathway

Studies in the yeast Saccharomyces cerevisiae have helped define mechanisms underlying the activity of the ubiquitin–proteasome system (UPS), uncover the proteasome assembly pathway, and link the UPS to the maintenance of cellular homeostasis. However, the spectrum of UPS substrates is incompletely defined, even though multiple techniques—including MS—have been used. Therefore, we developed a substrate trapping proteomics workflow to identify previously unknown UPS substrates. We first generated a yeast strain with an epitope tagged proteasome subunit to which a proteasome inhibitor could be applied. Parallel experiments utilized inhibitor insensitive strains or strains lacking the tagged subunit. After affinity isolation, enriched proteins were resolved, in-gel digested, and analyzed by high resolution liquid chromatography-tandem MS. A total of 149 proteasome partners were identified, including all 33 proteasome subunits. When we next compared data between inhibitor sensitive and resistant cells, 27 proteasome partners were significantly enriched. Among these proteins were known UPS substrates and proteins that escort ubiquitinated substrates to the proteasome. We also detected Erg25 as a high-confidence partner. Erg25 is a methyl oxidase that converts dimethylzymosterol to zymosterol, a precursor of the plasma membrane sterol, ergosterol. Because Erg25 is a resident of the endoplasmic reticulum (ER) and had not previously been directly characterized as a UPS substrate, we asked whether Erg25 is a target of the ER associated degradation (ERAD) pathway, which most commonly mediates proteasome-dependent destruction of aberrant proteins. As anticipated, Erg25 was ubiquitinated and associated with stalled proteasomes. Further, Erg25 degradation depended on ERAD-associated ubiquitin ligases and was regulated by sterol synthesis. These data expand the cohort of lipid biosynthetic enzymes targeted for ERAD, highlight the role of the UPS in maintaining ER function, and provide a novel tool to uncover other UPS substrates via manipulations of our engineered strain.

scholarly journals Piper longum: A review of its phytochemicals and their network pharmacological evaluation

2017 ◽  
Author(s):  
Neha Choudhary ◽  
Vikram Singh
Keyword(s):  
Drug Targets ◽  
Network Pharmacology ◽  
High Confidence ◽  
Protein Targets ◽  
Piper Longum ◽  
Protein Target ◽  
The Common ◽  
Novel Drug ◽  
Novel Drug Targets

AbstractPiper longum L. (P. longum, also called as long pepper) is one of the common culinary herb and has been extensively used as an important constituent of various indigenous medicines, specifically in traditional Indian medicinal system known as Ayurveda. Towards obtaining a global regulatory framework of P. longum’s constituents, in this work we first reviewed phytochemicals present in this herb and then studied their pharmacological and medicinal features using network pharmacology approach. We developed high-confidence level tripartite networks consisting of phytochemicals – protein targets – disease association and explain the role of its phytochemicals to various chronic diseases. 7 drug-like phytochemicals in this herb were found as the potential regulators of 5 FDA approved drug targets; and 28 novel drug targets were also reported. 105 phytochemicals were linked with immunomodulatory potency by pathway level mapping in human metabolic network. A sub-network of human PPI regulated by its phytochemicals was derived and various modules in this sub-network were successfully associated with specific diseases.Graphical abstractAbbreviationsP. longumPiper longum L.PCPhytochemicalPTProtein targetBPBiological pathwaysDADisease asscociationPCtNumber of protein targets corresponding to a particular phytochemicalTtTotal number of protein targets of P. longumADMETAbsorption, Distribution, Metabolism, Excretion and Toxicity.

scholarly journals COVID-19-related coagulopathy – Is transferrin a missing link?

2020 ◽  
Author(s):  
Katie-May McLaughlin ◽  
Marco Bechtel ◽  
Denisa Bojkova ◽  
Mark N. Wass ◽  
Martin Michaelis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Gene ◽  
Tissue Expression ◽  
Systematic Investigation ◽  
Gene Products ◽  
Expression Data ◽  
Proteomics Data ◽  
High Confidence ◽  
Infected Cells

AbstractSARS-CoV-2 is the causative agent of COVID-19. Severe COVID-19 disease has been associated with disseminated intravascular coagulation and thrombosis, but the mechanisms underlying COVID-19-related coagulopathy remain unknown. Since the risk of severe COVID-19 disease is higher in males than in females and increases with age, we combined proteomics data from SARS-CoV-2-infected cells with human gene expression data from the Genotype-Tissue Expression (GTEx) database to identify gene products involved in coagulation that change with age, differ in their levels between females and males, and are regulated in response to SARS-CoV-2 infection. This resulted in the identification of transferrin as a candidate coagulation promoter, whose levels increases with age and are higher in males than in females and that is increased upon SARS-CoV-2 infection. A systematic investigation of gene products associated with the GO term “blood coagulation” did not reveal further high confidence candidates, which are likely to contribute to COVID-19-related coagulopathy. In conclusion, the role of transferrin should be considered in the course of COVID-19 disease and further examined in ongoing clinic-pathological investigations.

scholarly journals Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host directed antivirals.

2021 ◽  
Author(s):  
Jingru Fang ◽  
Colette Pietzsch ◽  
George Tsaprailis ◽  
Gogce Crynen ◽  
Kelvin Frank Cho ◽  
...  
Keyword(s):  
Polymerase Activity ◽  
Host Factors ◽  
Lassa Virus ◽  
High Confidence ◽  
Biotin Ligase ◽  
Infected Cells ◽  
New Biology ◽  
Negative Sense ◽  
Transcription And Replication

Completion of the Lassa virus (LASV) life cycle critically depends on the activities of the virally encoded RNA-dependent RNA polymerase in replication and transcription of the negative-sense RNA viral genome in the cytoplasm of infected cells. We hypothesized that interactions with an array of cellular proteins may enable LASV polymerase to execute distinct viral RNA biosynthetic processes. To investigate this hypothesis, we applied proximity proteomics to define the interactome of LASV polymerase in cells, under conditions that recreate viral transcription and replication. We engineered a LASV polymerase-biotin ligase TurboID fusion protein that retained polymerase activity and successfully biotinylated the proximal proteome, which allowed us to identify 42 high-confidence hits that interact with LASV polymerase. We performed an siRNA screen to evaluate the role of the identified interactors in LASV infection, which uncovered six host factors for which their depletion affected LASV infection. We found that one polymerase interactor, eukaryotic peptide chain release factor subunit 3a (eRF3a/GSPT1), physically and functionally associated with LASV polymerase, exhibiting proviral activity. Accordingly, pharmacological targeting of GSPT1 resulted in strong inhibition of LASV infection. In summary, our work demonstrates the feasibility of using proximity proteomics to illuminate and characterize yet to be defined, host-pathogen interactomes, which can reveal new biology and uncover novel targets for the development of antivirals against LASV.

scholarly journals The role of identity and gender in seafood cooking skills

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Anders Wien ◽  
Siril Alm ◽  
Themistoklis Altintzoglou
Keyword(s):  
Survey Data ◽  
Design Methodology ◽  
Food Products ◽  
High Confidence ◽  
Content Type ◽  
Cooking Skills ◽  
And Gender ◽  
Insight Into

PurposeThe purpose of this study was to explore whether consumers' confidence in cooking skills related to seafood differed across genders, and if such difference could be explained by the identity-relevance of seafood cooking for men.Design/methodology/approachSurvey data was collected from a balanced sample of 515 Norwegian consumers.FindingsThe results showed that men (versus women) with high confidence in their seafood cooking skills have a lower preference for convenient seafood solutions, indicating that these men may be more reluctant to use food products that could hinder the cooking outcome being attributed to their cooking skills.Originality/valueThis study adds nuance to the understanding of male consumers as highly reliant on convenience products when cooking. More specifically, this study provides novel insight into how men function differently than women in relation to preparing seafood, suggesting that some men resist using convenient seafood solutions in order to express an identity as skillful in the kitchen.

Primary care provider involvement in thyroid cancer survivorship care.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e14028-e14028
Author(s):  
Archana Radhakrishnan ◽  
David Reyes-Gastelum ◽  
Sarah T. Hawley ◽  
Ann S. Hamilton ◽  
Kevin C. Ward ◽  
...  
Keyword(s):  
Primary Care ◽  
Thyroid Cancer ◽  
Cancer Survivorship ◽  
Primary Care Providers ◽  
Survivorship Care ◽  
Care Providers ◽  
High Confidence ◽  
Chi Squared

e14028 Background: While prior research has examined how primary care providers (PCPs) can help care for breast and colon cancer survivors, little is known about the role of PCPs in thyroid cancer survivorship. We surveyed PCPs to understand their involvement and confidence in providing several aspects of thyroid cancer survivorship care. Methods: Thyroid cancer patients (N = 2632) diagnosed in 2014-2015 and identified from the Georgia and LA SEER registries, were surveyed, and identified their PCPs, who then were also surveyed (N = 162, 56% response rate). PCPs were asked to report their: 1) involvement in thyroid cancer long-term surveillance (not involved: never/rarely vs. involved: sometimes/often/almost always involved); and 2) confidence in handling four aspects of thyroid cancer survivorship care (low: not at all/a little/somewhat vs. high: quite/very confident). We examined PCP factors (individual, practice, attitudes and beliefs) associated with PCP involvement in long-term surveillance using multivariable logistic regression. We then examined associations between PCP involvement in long-term surveillance and PCP confidence in handling the four aspects of thyroid cancer survivorship care using Chi-squared tests. Results: The majority of PCPs (76%) reported involvement in long-term surveillance. Adjusted odds of PCPs reporting involvement was greater among PCPs who somewhat/strongly believed that PCPs have the skills necessary to provide survivorship care (OR 4.33; 95% CI 1.38-15.37), and PCPs who noted clinical guidelines as being the most influential in guiding treatment (OR 4.48; 95% CI 1.67-13.07). PCP reports of high confidence in handling the four aspects of survivorship care were consistently less than 50%: when to refer patient to specialist (40%), role of neck ultrasound (36%), role of random thyroglobulin levels (27%), and when to end long-term surveillance (14%). PCPs who reported involvement in long-term surveillance were more likely to report high confidence in discussing the role of random thyroglobulin levels (33.3% vs. 7.9% for those not involved, p < 0.01) but not the other aspects of survivorship care. Conclusions: Though many PCPs reported they were involved in thyroid cancer long-term surveillance, gaps remain in their confidence in handling several aspects of thyroid cancer survivorship care. Guidelines were noted as important in influencing management; therefore, developing guidelines that specifically delineate PCP roles in thyroid cancer survivorship may present one opportunity to increase PCPs’ confidence about their participation.

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